Therapeutic Monitoring of Mood Stabilizers in Bipolar Disorder : Lithium and Anticonvulsants

Abstract

Atypical antipsychotics are widely used in the treatment of bipolar disorder. 1 Lurasidone is one of the medications approved by the Food and Drug Administration for the treatment of bipolar depression, both as adjunct and monotherapy. 2 Similar to other medications in its class, lurasidone has been reported to induce mania in patients being treated for bipolar depression. 3,4 We present a case series of 4 patients that developed acute mania with lurasidone, an effect that appears to be dose-dependent.