Therapeutic, Molecular and Computational Aspects of Novel Monoamine Oxidase (MAO) Inhibitors

Ramesh, Muthusamy; Dokurugu, Yussif M.; Thompson, Michael D.; Soliman, Mahmoud E. S.

doi:10.2174/1386207320666170310121337

Cited by 14 publications

(3 citation statements)

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“…Some of them are considered to be life-threatening, especially the hypertensive crisis that results after consumption of tyramine containing foods. 41 Further, the drug-drug and drug-food interactions are also frequent with the MAOIs therapy. Particularly, the serotonin syndrome is reported to occur due to interaction between MAOIs and Selective serotonin reuptake inhibitors (SSRIs).…”

Section: Discussionmentioning

confidence: 99%

Anxiolytic-like and antidepressant-like effects of ethanol extract of Terminalia chebula in mice

Mani

Sajid

Rabbani

et al. 2021

Journal of Traditional and Complementary Medicine

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Terminalia chebula (T.chebula) fruit is referred as “King of Medicines” in Tibet and is listed as a key plant in “Ayurvedic Materia Medica” due to its diverse pharmacological activity. The present study was aimed to investigate the comorbid antidepressant-like and anxiolytic-like effects of ethanol extract from T.chebula fruit using experimental behavioral tests in mice. In addition, the study explored the effects of extract on monoamine oxidase –A (MAO-A) levels in mouse brain. Two doses of the T.chebula extract (100 or 200 mg/kg, p.o.) were treated continuously for fifteen days to mice. Regarding antidepressant-like effects, the treatment of T.chebula extract at both dose (100 or 200 mg/kg, p.o.) levels resulted with significant (p < 0.001) reduction in duration of immobility time and increase in swimming time as compared to control group in forced swimming test. Moreover, both doses declined the duration of immobility time in the tail suspension test and increased the number of crossing in the center area using open-field test. Additionally, the dose 200 mg/kg treatment showed a significant reduction (p < 0.05) in MAO-A activity in mouse brain. For anxiolytic activity, both doses significantly (p < 0.001) improved the time spent in open arm and the number of head dips in elevated plus maze test. The higher duration of time spent in light chamber and higher number of crossing between the light and dark chambers by extract treatment in light-dark box test also supported the anxiolytic behavior. The obtained results supported the antidepressant-like and anxiolytic-like effects of ethanol extract of T.chebula in mice.

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Section: Discussionmentioning

confidence: 99%

Anxiolytic-like and antidepressant-like effects of ethanol extract of Terminalia chebula in mice

Mani

Sajid

Rabbani

et al. 2021

Journal of Traditional and Complementary Medicine

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“…( Maes and Meltzer, 1995 , Asberg, 1997 , Placidi, 2001 , Stockmeier, 2003 ). The monoamine hypothesis has for many years served as the foundation for the production of antidepressant drugs, specifically monoamine oxidase inhibitors, to restore the normal levels of monoamines ( Thomsen and Sorensen, 2007 ; Ramesh et al, 2017 ; Jesulola et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Depression in Sub-Saharan Africa

Gbadamosi

Henneh

Aluko

et al. 2022

IBRO Neuroscience Reports

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“…Inhibiting or reversing the atrophy that occurs in neurons, in addition to improving cell survival and function, would be the means by which this goal would be achieved 23 . Because it contains a wide variety of important phytoconstituents, such as gallotannic acid, bellericanin, ellagic acid, gallic acid, termilignan, thanni lignan, flavone, and anolignan B, tannins, ellagic acid, ethyl gallate, galloyl glucose, and chebulaginic acid, as well as phenyllemblin, sitosterol 24 , and As a result of the presence of these compounds, it demonstrates a diverse array of pharmacological activities, some of which include antisecretory, analgesic, antihypertensive, antidiarrheal activity, antimicrobial activity, anti-diabetic, antioxidant, antiulcer, antipyretic, hepatoprotective, anticancer, angiogenesis, and antidepressant-like activity 25,26 .…”

Section: Fig 2 Effect Of Aqueous Extract Terminalia Chebula Fruit Pul...mentioning

confidence: 99%

Evaluation of The Antidepressant Properties of Aqueous Extract Terminalia Chebula Fruit Pulp in Wistar Albino Rats.

Choudhary

Manivannan

Ramalingam

et al. 2022

Int J Life Sci Pharm Res

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Between 9 and 46% of those being treated for major depressive disorder had a partial or no response to antidepressants. Research is needed to produce a more effective and safer antidepressant. Terminalia chebula stimulates the CNS. The major goal of this research is to determine whether chronic administration of aqueous extract of Terminalia chebula fruit pulp dosages of (100, 200, and 400 mg/kg) have antidepressant effects. Terminalia chebula behavioural model of rats when supplied over three to four months in experimental rats. Wistar albino rats weighing 200 to 300 grams and one to two months old were utilized. For all experiments, healthy wistar albino rats of either sex were separated into six groups with equal numbers of animals. The antidepressant properties of Terminalia chebula fruit pulp were investigated using two different experimental methods. Both the forced swimming and the tail suspension tests fall into this category. Terminalia chebula fruit pulp was given at doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg. To treat depression, a standard dose of antidepressant medication (10 mg/kg) of imipramine was administered. Each group of rats was tested one hour after treatment. A rat behavioural stress paradigm found that Terminalia chebula had a nephroprotective effect. Antioxidant phytochemicals like Terminalia chebula were extracted and quantified. The abundance of phytochemicals implies that this might be a good source for antioxidants and depression therapy. The current evidence is intriguing and may be employed as a medicine candidate after additional study and clinical tests.

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Therapeutic, Molecular and Computational Aspects of Novel Monoamine Oxidase (MAO) Inhibitors

Abstract: The present review describes the importance of structural features of potential chemical scaffolds as well as the role of computational approaches like ligand docking, molecular dynamics, QSAR and pharmacophore modeling in the development of novel MAO inhibitors.

Cited by 14 publications

References 0 publications

Anxiolytic-like and antidepressant-like effects of ethanol extract of Terminalia chebula in mice

Anxiolytic-like and antidepressant-like effects of ethanol extract of Terminalia chebula in mice

Depression in Sub-Saharan Africa

Evaluation of The Antidepressant Properties of Aqueous Extract Terminalia Chebula Fruit Pulp in Wistar Albino Rats.

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