Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders

Lee, Hyo‐Jeong; Choi, Jong Kyoung; Ryu, Han Seung; Choi, Chang Hwan; Kang, Eun Hee; Park, Kyung Sik; Ye, Min; Hong, Kyoung Sup

doi:10.5056/jnm16124

Cited by 23 publications

(13 citation statements)

References 123 publications

(143 reference statements)

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“…The importance of gut microbiota in health and disease is becoming increasingly evident, and there is a growing body of literature on the therapeutic potential of probiotics in GI disorders like irritable bowel syndrome (IBS) and many other conditions. The proposed mechanisms of action for the beneficial effects of probiotics include competitive exclusion of pathogenic microorganisms, inhibition of pathogen adhesion, production of anti‐microbial substances and modulation of the immune system .…”

Section: Introductionmentioning

confidence: 99%

Systematic review: probiotics in the management of lower gastrointestinal symptoms – an updated evidence‐based international consensus

Hungin

Mitchell

Whorwell³

et al. 2018

Aliment Pharmacol Ther

113

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SummaryBackgroundIn 2013, a systematic review and Delphi consensus reported that specific probiotics can benefit adult patients with irritable bowel syndrome (IBS) and other gastrointestinal (GI) problems.AimTo update the consensus with new evidence.MethodsA systematic review identified randomised, placebo‐controlled trials published between January 2012 and June 2017. Evidence was graded, previously developed statements were reassessed by an 8‐expert panel, and agreement was reached via Delphi consensus.ResultsA total of 70 studies were included (IBS, 34; diarrhoea associated with antibiotics, 13; diarrhoea associated with Helicobacter pylori eradication therapy, 7; other conditions, 16). Of 15 studies that examined global IBS symptoms as a primary endpoint, 8 reported significant benefits of probiotics vs placebo. Consensus statements with 100% agreement and “high” evidence level indicated that specific probiotics help reduce overall symptom burden and abdominal pain in some patients with IBS and duration/intensity of diarrhoea in patients prescribed antibiotics or H. pylori eradication therapy, and have favourable safety. Statements with 70%‐100% agreement and “moderate” evidence indicated that, in some patients with IBS, specific probiotics help reduce bloating/distension and improve bowel movement frequency/consistency.ConclusionsThis updated review indicates that specific probiotics are beneficial in certain lower GI problems, although many of the new publications did not report benefits of probiotics, possibly due to inclusion of new, less efficacious preparations. Specific probiotics can relieve lower GI symptoms in IBS, prevent diarrhoea associated with antibiotics and H. pylori eradication therapy, and show favourable safety. This study will help clinicians recommend/prescribe probiotics for specific symptoms.

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Section: Introductionmentioning

confidence: 99%

Systematic review: probiotics in the management of lower gastrointestinal symptoms – an updated evidence‐based international consensus

Hungin

Mitchell

Whorwell³

et al. 2018

Aliment Pharmacol Ther

113

View full text Add to dashboard Cite

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“…Chronic constipation and diarrhea have been associated with gut microbiota and immune function. [ 47 , 48 ] Therefore, we may expect associations between SPCC and these gastrointestinal dysfunctions, although no clinical studies have previously investigated these associations. Our study showed that gastric discomfort was associated with SPCC regardless of intestinal dysfunctions (constipation and diarrhea), which suggests that both colon and gastric function probably interfere with common cold infections.…”

Section: Discussionmentioning

confidence: 99%

Potential common factors associated with predisposition to common cold in middle-aged and elderly Japanese

et al. 2018

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People worldwide frequently catch a common cold, which occasionally develops into secondary severe conditions such as pneumonia. However, it is unclear whether predisposition to the common cold is associated with the individual's characteristics including age, body weight, lifestyles, diets, and intestinal functions, besides exposure to a responsible pathogen. We addressed this issue epidemiologically considering many relevant clinical factors.We reviewed data from a cross-sectional study consisting of 39,524 apparently healthy Japanese aged 40 to 79 years (26,975 men and 12,549 women) who underwent a checkup in 2007. Self-reported predisposition to common cold (SPCC) and relevant clinical conditions and parameters were considered.We observed no significant difference in most clinical parameters including age, body mass index (BMI), glycated hemoglobin (HbA1c), and prevalence of men and current smokers between subjects with and without SPCC. In univariate analysis, circulating white blood cell (WBC) count and serum alanine-aminotransferase (ALT) were significantly higher in subjects with SPCC than in those without, whereas serum high-density lipoprotein cholesterol (HDL-C) and duration of sleep were lower. In logistic regression analysis after full adjustment for relevant confounding factors, BMI categories except BMI of ≥27.0 kg/m2 were significantly associated with SPCC compared with BMI of 23.0 to 24.9 kg/m2. Short duration of sleep (≤5 hours), occasional alcohol drinking, and no-exercise were significantly associated with SPCC compared with 7 hours sleep duration, no-drinking alcohol, and low frequent exercise (twice per month), respectively. All gastrointestinal disorders (gastric complaints, constipation, and diarrhea) were independently associated with SPCC. Imbalanced diet and taking a snack were also associated with SPCC in a degree dependent manner. Furthermore, WBC count, serum ALT, and HDL-C (as continuous variables) were associated with SPCC (HDL-C was inversely), whereas no significant association was observed between SPCC and age, smoking, HbA1c, and pharmacotherapy for diabetes, hypertension, and dyslipidemia.Our results demonstrated that multifactorial conditions and parameters might be simultaneously associated with the predisposition to common cold. Prospective studies including detailed common cold questionnaire and measurements are needed to confirm currently suspected causative and protective factors.

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“…Interestingly, the low FODMAP diet was recently shown to reduce relative abundance of bacteria involved in gas consumption, as well as an eight-fold reduction in histamine, a novel finding that may also help explain the benefits of this dietary approach [182]. Beyond the low FODMAP diet, there is a notable lack of studies of gut microbiota-targeted dietary interventions in IBS, despite their theoretical potential [183].…”

Section: Dysbiosismentioning

confidence: 99%

Does Irritable Bowel Syndrome Exist? Identifiable and Treatable Causes of Associated Symptoms Suggest It May Not

Brown

2019

GastrointestDisord

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Significant shortcomings in irritable bowel syndrome (IBS) diagnosis and treatment may arise from IBS being an “umbrella” diagnosis that clusters several underlying identifiable and treatable causes for the same symptom presentation into one classification. This view is compatible with the emerging understanding that the pathophysiology of IBS is heterogeneous with varied disease mechanisms responsible for the central pathological features. Collectively, these converging views of the pathophysiology, assessment and management of IBS render the traditional diagnosis and treatment of IBS less relevant; in fact, they suggest that IBS is not a disease entity per se and posit the question “does IBS exist?” The aim of this narrative review is to explore identifiable and treatable causes of digestive symptoms, including lifestyle, environmental and nutritional factors, as well as underlying functional imbalances, that may be misinterpreted as being IBS.

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Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders

Cited by 23 publications

References 123 publications

Systematic review: probiotics in the management of lower gastrointestinal symptoms – an updated evidence‐based international consensus

Systematic review: probiotics in the management of lower gastrointestinal symptoms – an updated evidence‐based international consensus

Potential common factors associated with predisposition to common cold in middle-aged and elderly Japanese

Does Irritable Bowel Syndrome Exist? Identifiable and Treatable Causes of Associated Symptoms Suggest It May Not

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