Therapeutic modulation of ATP sensitive potassium channels in ischaemia

Wc, Cole; Ea, Aeillo

doi:10.1093/cvr/28.2.286

Cited by 2 publications

(2 citation statements)

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“…[ 6 ] Furthermore, our results reveal one limitation of ABI is the existence of “false negatives” in the presence of partial arterial stenosis with calcified walls, thus portraying a normal ABI patient in the presence of CLI. Another clinically relevant phenomenon is that distal embolization can be induced following PTA treatment of stenosis [ 7 , 8 ] due to residual particles of the atheromatous plaque.…”

Section: Discussionmentioning

confidence: 99%

Improvement of quality of life in diabetic patients treated with percutaneous transluminal angioplasty

Páez¹,

Baños²,

Abad³

et al. 2018

Medicine

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To assess the quality of life (QoL) of treated patients in order to evaluate the success of peripheral transluminal angioplasty (PTA) and correlate physical parameters with clinical progress at 6 months post-PTA.According to TASC II classifications, 69 patients were selected for PTA. Clinical evaluation and diagnostic tests were performed before, after and after 6 months following PTA. The SF-36 QoL questionnaire was added as an additional parameter.Fifty one patients were included in the study. The ankle-brachial index (ABI) increased from 0.49 ± 0.11 before PTA, to 0.81 ± 0.14 after PTA (P < .001) and 0.76 ± 0.10 at 6 months following PTA (P < .001). Transcutaneous oxygen pressure (TcPO2) increased from 28.05 ± 3.15 mm Hg before PTA, to 39.89 ± 4.12 after PTA (P < .001) and 46.4 ± 3.81 at 6 months following PTA (P < .001). The lumen of the affected blood vessel increased from 29 ± 18% before PTA, to 81 ± 10.3% after PTA (P < .001). SF-36 values increased from 29 ± 18 before PTA, to 81 ± 10.36 at 6 months following PTA (P < .001).The improvement of QoL is the parameter that best describes the symptoms and functionality of the patient, therefore, should be used to determine the successful PTA. Although ABI and TcPO2 with arteries functionality and tissue oxygenation, they are not show a significant correlation with all parameters determined in the QoL questionnaire.

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Section: Discussionmentioning

confidence: 99%

Improvement of quality of life in diabetic patients treated with percutaneous transluminal angioplasty

Páez¹,

Baños²,

Abad³

et al. 2018

Medicine

View full text Add to dashboard Cite

show abstract

“…A clinically relevant situation is that PTA can induce the formation of a "dust" of atheromatous plaque and distal embolization after treatment of stenosis. 9,10 This might explain the reduction of oxygen in some patients in whom an increase in the arterial diameter is not followed by a concomitant increase in TcPO 2 but, paradoxically, shows a decrease in the same. In our study, another 7.5% of the patients had a TcPO 2 lower than the initial PTA and were inconspicuous after Doppler imaging (ABI).…”

Section: Discussionmentioning

confidence: 99%