Therapeutic Methylprednisolone and Infimab Decrease the Severity of Organ Dysfunction in Pancreatic Duct Ligation Model of Severe Acute Pancreatitis in Wistar Rats

Abstract

Introduction: There is no standardized and widely used model of severe acute pancreatitis (SAP) with organ failure. This may limit drug development for severe acute pancreatitis. Dysregulated and hyperimmune responses are the root cause of organ failure in SAP. We established a rat model of SAP with organ failure and evaluated