Therapeutic Metabolic Inhibition: Hydrogen Sulfide Significantly Mitigates Skeletal Muscle Ischemia Reperfusion Injury In Vitro and In Vivo

Henderson, Peter W.; Singh, Sunil P.; Weinstein, Andrew L.; Nagineni, Vijay; Rafii, Daniel C.; Kadouch, Daniel J.; Krijgh, David D.; Spector, Jason A.

doi:10.1097/prs.0b013e3181f446bc

Cited by 34 publications

(35 citation statements)

References 28 publications

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“…It has been implicated that reactive oxygen species played a role in physiopathology of much diseases 63,64 . As a conclusion, the lipid peroxidation results in cellular injury, causing structural and functional alterations in the cells [65][66][67] . SOD, CAT and GPx are known as endogenous antioxidants, and the first-line defence mechanism against free radical damage 58-70 .…”

Section: Resultsmentioning

confidence: 99%

Quercetin protects rat skeletal muscle from ischemia reperfusion injury

Akdemir

Gülçın

Karagöz

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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In this study, we investigated the potential beneficial effects of quercetin on skeletal muscle ischemia reperfusion injury. Twenty-four Sprague-Dawley type rats were randomly divided into four groups. In the sham group, only gastrocnemius muscle were removed and given no quercetin. In ischemia group, all the femoral artery, vein and collaterals were occluded in the left hindlimb by applying tourniquate under general anaesthesia for three hours but reperfusion was not done. In the Quercetin + Ischemia reperfusion group, quercetin (200 mg kg À1 dose orally) was given during one-week reoperation and later ischemia reperfusion model was done. Finally, gastrocnemius muscle samples were removed to measure biochemical parameters. The biomarkers, MDA levels, SOD, CAT and GPx activities, were evaluated related to skeletal muscle ischemia reperfusion injury. MDA levels reduced and SOD, CAT and GPx activities increased significantly in Quercetin + Ischemia reperfusion group. Results clearly showed that Quercetin have a protective role against oxidative damage induced by ischemia reperfusion in rats.

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Section: Resultsmentioning

confidence: 99%

Quercetin protects rat skeletal muscle from ischemia reperfusion injury

Akdemir

Gülçın

Karagöz

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…It is also a cause of irreversible damage to skeletal muscle made ischemic either as the result of pathologic hypoperfusion or of a planned surgical intervention. On the basis of results of both in vitro and in vivo experiments, it was recently concluded that the preischemic or postischemic delivery of NaHS limits I/R-induced cellular damage and confers significant long-term protection, that intravenous or even intra-arterial delivery of an H 2 S donor would provide more focused treatment of target tissue and, when administered in appropriate doses and within the proper time frame, H 2 S holds significant promise as a cytoprotective agent (65).…”

Section: Cytoprotection and Pharmacological Conditioningmentioning

confidence: 99%

Hydrogen Sulfide in Biochemistry and Medicine

Predmore

Lefer

Gojon³

2012

Antioxidants & Redox Signaling

348

259

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Significance: An abundance of experimental evidence suggests that hydrogen sulfide (H 2 S) plays a prominent role in physiology and pathophysiology. Many targets exist for H 2 S therapy. The molecular targets of H 2 S include proteins, enzymes, transcription factors, and membrane ion channels. Recent Advances: Novel H 2 S precursors are being synthesized and discovered that are capable of releasing H 2 S in a slow and sustained manner. This presents a novel and advantageous approach to H 2

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“…protection from ischemia/reperfusion injury has been demonstrated in a number of extracardiac organs, including the kidney (171), which presumably offsets the reduction in endogenous H 2 S production (192), liver and small intestine (52,198), skeletal muscle (49,51), and cellular components of cutaneous tissue (50). As in the vasculature, H 2 S has been proposed to combine with NO to produce a nitrosothiol with inotropic properties (195,194).…”

Section: R301 Therapeutic Potential Of H2smentioning

confidence: 99%

The therapeutic potential of hydrogen sulfide: separating hype from hope

Olson

2011

American Journal of Physiology-Regulatory, Integrative and Comp

160

154

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Hydrogen sulfide (H2S) has become the hot new signaling molecule that seemingly affects all organ systems and biological processes in which it has been investigated. It has also been shown to have both proinflammatory and anti-inflammatory actions and proapoptotic and anti-apoptotic effects and has even been reported to induce a hypometabolic state (suspended animation) in a few vertebrates. The exuberance over potential clinical applications of natural and synthetic H2S-“donating” compounds is understandable and a number of these function-targeted drugs have been developed and show clinical promise. However, the concentration of H2S in tissues and blood, as well as the intrinsic factors that affect these levels, has not been resolved, and it is imperative to address these points to distinguish between the physiological, pharmacological, and toxicological effects of this molecule. This review will provide an overview of H2S metabolism, a summary of many of its reported “physiological” actions, and it will discuss the recent development of a number of H2S-donating drugs that show clinical potential. It will also examine some of the misconceptions of H2S chemistry that have appeared in the literature and attempt to realign the definition of “physiological” H2S concentrations upon which much of this exuberance has been established.

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Therapeutic Metabolic Inhibition: Hydrogen Sulfide Significantly Mitigates Skeletal Muscle Ischemia Reperfusion Injury In Vitro and In Vivo

Cited by 34 publications

References 28 publications

Quercetin protects rat skeletal muscle from ischemia reperfusion injury

Quercetin protects rat skeletal muscle from ischemia reperfusion injury

Hydrogen Sulfide in Biochemistry and Medicine

The therapeutic potential of hydrogen sulfide: separating hype from hope

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