Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure

Fu, Yu; Zhao, Zhengang; Wu, Yuankui; Ke-ming, WU; Xu, Xiaouan; Liu, Yue; Tong, Chongyi

doi:10.1016/j.jep.2011.08.077

Cited by 29 publications

(23 citation statements)

References 40 publications

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“…Therefore, the side effects of TG on female reproductive system can be used to induce a POF animal model. Chen et al [41] have established a mouse POF model via subcutaneous injection of TG, while TG-induced rat POF model has also been established and widely used for reproductive experimental studies [38, 42]. In the current study, we found that BTR not only reverts an abnormal estrous cycle and a decreased ovary index in this model but also improves the abnormal secretion of reproductive hormones associated with POF.…”

Section: Discussionsupporting

confidence: 62%

“…Second, the results of mechanistic study are still preliminary; additional studies are necessary to elaborate the precise signaling pathways that are involved in the pro-angiogenic and anti-apoptotic effects of BTR. Additionally, it should be noted that there was a great discrepancy with previous literature as to the serum level of E2 in experimental animals [38, 39], which may be due to differences in detection methods or assay kits across the studies. This indicates that the assay of serum E2 level should be carefully optimized in the future.…”

Section: Discussionmentioning

confidence: 77%

“…As compared with other TCM formulas, e.g. Tongmai Dasheng Tablet [38] or Luan-Pao-Prescription [39], BTR only contains four herbs, which may increase safety and reduce treatment cost. In this study, we used a TG-induced POF rat model to investigate the effects of BTR for POF and the underlying mechanisms.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Bushen Tianjing Recipe in a rat model of tripterygium glycoside-induced premature ovarian failure

Tan

Jiang

et al. 2017

Chin Med

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BackgroundBushen Tianjing Recipe (BTR) is a traditional Chinese herbal medicine that has been prescribed for premature ovarian failure (POF) for decades in China. Nevertheless, little is known regarding its underlying molecular mechanism. In the present study, we investigated the effects of BTR in a tripterygium glycoside (TG)-induced-POF rat model.MethodsThree doses of BTR were administered via intragastric gavage to adult female Sprague–Dawley (SD) rats with TG-induced POF. After 15 days of treatment, the estrous cycle was examined by vaginal smear analysis. Serum levels of estradiol, follicle-stimulating hormone, progesterone, and testosterone were measured by radioimmunoassay. Histological analysis and assessment of apoptosis were performed after hematoxylin and eosin staining of ovarian tissue sections. The expression of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor 2 (VEGFR2), anti-apoptotic factor Bcl-2, and pro-apoptotic factors Bax and caspase 3 in ovaries of animals was examined by an immunohistochemistry process.ResultsBTR not only reverted an abnormal estrous cycle and decreased the ovary index in POF rats but also improved the abnormal secretion of reproductive hormones associated with POF. In addition, treatment with BTR can protect ovaries from TG-induced damage, induce intraovarian expression of VEGF and VEGFR2, and regulate intraovarian expression of apoptosis-related proteins.ConclusionsOur results show that BTR is effective in the treatment of TG-induced POF rats. Promotion of angiogenesis and anti-apoptosis are most likely to contribute to the effects of BTR against POF.Electronic supplementary materialThe online version of this article (doi:10.1186/s13020-017-0131-3) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 77%

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Effects of Bushen Tianjing Recipe in a rat model of tripterygium glycoside-induced premature ovarian failure

Tan

Jiang

et al. 2017

Chin Med

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“…Chemotherapeutic drugs can exceedingly remove granulosa cells which are essential for oocyte survival and follicle development (Mohamed et al, 2018). Furthermore, TG and CTX-induced POF in rat models (Fu et al, 2012;Hershlag & Schuster, 2002;Sanders et al, 1996;Su et al, 2016;Takehara et al, 2013;Terraciano et al, 2014).…”

Section: Tissue Engineering and Pofmentioning

confidence: 99%

Premature ovarian failure and tissue engineering

Ghahremani-Nasab

Ghanbari

Jahanbani

et al. 2019

Journal Cellular Physiology

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“…Moreover, some studies have also indicated that herbal medicine may be beneficial for improving ovarian function in polycystic ovary syndrome [Ma et al 2011] and POF [Fu et al 2012]. Therefore, it is worth considering whether herbal medicine can prevent and treat ovary dysfunction induced by chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Recovery of ovary function impaired by chemotherapy using Chinese herbal medicine in a rat model

Tian

Gao

et al. 2014

Systems Biology in Reproductive Medicine

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(2014) Recovery of ovary function impaired by chemotherapy using Chinese herbal medicine in a rat model, Systems Biology in Reproductive Medicine, 60:5, 293-303, DOI: 10.3109/19396368.2014.920057 To link to this article: https://doi.org/10. 3109/19396368.2014 AbstractThe ovary is not only involved in female germ cell development and maturation, but also adjusts female endocrinology. Its function is severely impaired during chemotherapy, and premature ovarian failure may be induced. Chinese herbal medicine (CHM) has displayed significant potential in the treatment of female endocrine disorders; however, it is unknown whether it can recover ovarian function impaired by chemotherapy. In the present study, CHM was used to treat rat models of ovarian dysfunction impaired by chemotherapeutic drugs. Three groups were included in this study: a prevention group, a treatment group, and a prevention-treatment group. Routine gonadotropin-releasing hormone agonists (GnRHa) treatment was used as a control. The results showed that body weight, fertility, estrus days, hormone levels, and ovary weight were restored when CHM was administered in these rat models. Moreover, in the prevention-treatment group, the number of follicles at each developmental stage significantly increased compared with the prevention or treatment group. Furthermore, the number of apoptotic cells significantly decreased, and the relative mRNA expression of caspase-3 significantly decreased, in the prevention-treatment group. The results of gene expression analysis indicated that the expression of anti-Mü llerianhormone (AMH) which indicates ovarian preservation was significantly up-regulated in the preventiontreatment group and was similar to normal rats. The expression of growth differentiation factor 9 (GDF9) was significantly enhanced in both the prevention-treatment group and the GnRHa group, which suggested that the oocytes were of better quality. Finally, we found that there were no differences in body weight and fertility in the offspring conceived by the drug-treated rats, which partly indicated the safety of the medicine. In conclusion, Chinese herbal medicine showed a beneficial role in the recovery of ovary function in these rat models and has significant potential in the clinic.

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Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure

Cited by 29 publications

References 40 publications

Effects of Bushen Tianjing Recipe in a rat model of tripterygium glycoside-induced premature ovarian failure

Effects of Bushen Tianjing Recipe in a rat model of tripterygium glycoside-induced premature ovarian failure

Premature ovarian failure and tissue engineering

Recovery of ovary function impaired by chemotherapy using Chinese herbal medicine in a rat model

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