Therapeutic Mechanism of Kai Xin San on Alzheimer’s Disease Based on Network Pharmacology and Experimental Validation

Wang, Kan; Yang, Rong; Chen, Tuan-tuan; Qin, Meirong; Wang, Ping; Kong, Mei

doi:10.1007/s11655-022-3589-5

Cited by 4 publications

(2 citation statements)

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“…Although KXS has been used to treat mental disorders clinically, the exact mechanisms are unclear. [9] The method of combing network pharmacology study and molecular docking were used to predict the potential mechanisms of KXS treating the overlapping pathogeny of anxiety and PTSD. Sixty-four bioactive components were derived from KXS, and 3474 target genes of PTSD and 4910 target genes of anxiety were selected from several databases, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…KXS has treated a variety of mental disorders, but the mechanisms of KXS are still unclear. [9][10][11] Network pharmacology is a common method that collects bioactive components of drugs and related pathways or proteins of diseases through various databases. And then exploring the mechanisms of drugs by constructing and analyzing a "drugs-targets-diseases" network.…”

Section: Introductionmentioning

confidence: 99%

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Exploring the potential mechanism of Kaixinsan powder for the same pathogenesis of PTSD and anxiety based on network pharmacology and molecular docking: A review

Li,

Wang,

et al. 2023

Medicine

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Background: Post-traumatic stress disorder (PTSD) and anxiety are common mental illnesses and there are many similar pathogenesis and clinical manifestations between PTSD and anxiety. Kaixinsan powder (KXS), a commonly used prescription in traditional Chinese medicine, has been widely used to treat PTSD and anxiety. This study aims to explore the potential mechanisms of KXS for the same pathogenesis of PTSD and anxiety using a network pharmacology approach. Methods: The bioactive components and relevant target genes of KXS were obtained from the database about Traditional Chinese Medicine. The key genes of PTSD and anxiety were derived from disease databases. Subsequently, the network of protein–protein interaction and a network of “drug-components-disease-targets” was constructed. In order to treat PTSD and anxiety, gene ontology enrichment and signaling pathway enrichment were analyzed by using R language and components-core targets associated were validated by molecular docking. Results: One hundred three targets of KXS in treating PTSD and anxiety were identified. The results of protein–protein interaction analysis and molecular docking indicated that AKT1 and IL-6 were crucial targets. Moreover, KEGG analysis has shown that neuroactive ligand-receptor interaction, calcium signaling pathway, and cAMP signaling pathway may play crucial roles in treating PTSD and anxiety. Ten biological process, 10 molecular function, and 10 cellular component were revealed via gene ontology analysis. Conclusions: The network pharmacology study and molecular docking indicated that KXS treated anxiety and PTSD by multiple components, targets, and signaling pathways. These results provide an important reference for subsequent basic research on PTSD and anxiety.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%