Cognitive rehabilitation is as an important goal of rehabilitation therapy, which aims to help the person with neurological disability to acquire the highest level of cognitive functioning and of functional autonomy. Cognitive impairments in memory, language, judgement, attention, visuo-spatial perception are important blocks in acquiring functional independence. Cognitive rehabilitation therapy is "a systematic, functionally oriented service of therapeutic cognitive activities directed to achieve functional changes by reinforcing, strengthening or establishing previously learned patterns of behavior or establishing new patterns of cognitive activity or mechanisms to compensate ". The cognitive treatment programs include retraining strategies or the use of compensatory skills, but also counseling, environmental reorganization and use of educational and vocational training facilities. Cognitive rehabilitation requires a sustained and coordinated effort from a large team, including the patient, family and caregivers. There is an increasing evidence supporting the role and efficacy of cognitive rehabilitationin each cognitive domain. In the future, there is a need to develop innovative treatments, aiming to modulate cortical networks and to obtain long term improvements of all cognitive functions.