Therapeutic inorganic ions in bioactive glasses to enhance bone formation and beyond

Hoppe, Alexander; Mouriño, Viviana; Boccaccını, Aldo R.

doi:10.1039/c2bm00116k

Cited by 174 publications

(115 citation statements)

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“…For this reason, there is a general trend to upgrade properties with some of the well known therapeutical ions because of their biological action [14][15][16]. The development of the three families of glasses was together with an increase of the textural properties (surface area and pore volume) in going from the dense MPGs to the MBGs exhibiting over 500 m 2 /g of surface area and more than 0.5 cm 3 /g of pore volume.…”

Section: Introductionmentioning

confidence: 99%

Glasses in bone regeneration: A multiscale issue

Salinas

Vallet‐Regí

2016

Journal of Non-Crystalline Solids

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Highligths MBGs containing small amounts of Ga, Ce or Zn exhibit high in vitro bioactivity  The bioactive response is preserved after obtaining 3D scaffolds  These scaffolds are optimum candidates for bone tissue engineering applications  MBG scaffold with 4% ZnO exhibit bactericide action against S. Aureus  The effects of the extra ions is sometimes complex and needs to be investigated 2 Abstract 3D scaffolds based in mesoporous bioactive glasses (MBGs) are being widely investigated to use in bone tissue engineering (TE) applications. These scaffolds are often obtained by rapid prototyping (RP) and exhibit an array of interconnected pores in a hierarchy of sizes. The ordered mesopores network (around 4 nm in diameter), is optimal for the adsorption and release of bone inductor biomolecules, and the arrangement of macropores over 100 m facilitates the bone cell ingrowths and angiogenesis. Nevertheless MBGs composition can be varied almost infinitely at the atomic scale by including in the glass network oxides of inorganic elements with a therapeutic action. In this article the synthesis and characterization of MBG scaffolds based on the 80%SiO2-15%CaO-5%P2O5 (in mol-%) glass with substitutions up to 3.5% of Ga2O3 or Ce2O3 or 7.0% of ZnO is revisited. The substituent inclusion and the RP processing slightly decrease the surface area, the pore volume and the mesoporous order as well as their bioactive response in solutions mimicking blood plasma. However, these values still remain useful for bone TE applications. Results exhibiting the bactericide action of MBG scaffolds containing ZnO are also presented. KeywordsMesoporous bioactive glass scaffolds; Ga, Ce and Zn as therapeutical ions; bactericide capability; bone tissue engineering 3

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Section: Introductionmentioning

confidence: 99%

Glasses in bone regeneration: A multiscale issue

Salinas

Vallet‐Regí

2016

Journal of Non-Crystalline Solids

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“…5 A growing number of publications have shown experimental evidence about the biological effects of the ionic dissolution products released from bioceramic materials. [6][7][8][9][10] Within this context, it is important to mention the progress made with bioactive glasses (BGs). 6,[8][9][10] The most widely used BGs are amorphous solids based on a silicate matrix.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8][9][10] Within this context, it is important to mention the progress made with bioactive glasses (BGs). 6,[8][9][10] The most widely used BGs are amorphous solids based on a silicate matrix. [11][12][13][14] Although a growing number of publications have shown that the BGs in the 45S5 system (in weight%: 45% SiO 2 , 24.5% Na 2 O, 24.5% CaO, 6% P 2 O 5 (Bioglass®)) or related compositions stimulate angiogenesis, 15 the specic mechanisms that accelerate neovascularization in the presence of the ions released by the dissolution of BGs of different chemical composition have not yet been elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass

et al. 2015

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In regenerative medicine of vascularized tissues, there is a great interest in the use of biomaterials that are able to stimulate angiogenesis, a process necessary for rapid revascularization to allow the transport and exchange of oxygen, nutrients, growth factors and cells that take part in tissue repair and/or regeneration. An increasing number of publications have shown that bioactive glasses stimulate angiogenesis. Because it has been established that boron (B) may play a role in angiogenesis, the aim of this study was to assess the in vivo angiogenic effects of the ionic dissolution products that from a bioactive glass (BG) in the 45S5 system doped with 2 wt% B 2 O 3 (45S5.2B). The pro-angiogenic capacity of 45S5.2B BG was assessed on the vasculature of the embryonic quail chorioallantoic membrane (CAM).Ionic dissolution products from 45S5.2B BG increased angiogenesis. This is quantitatively evidenced by the greater expression of integrin a v b 3 and higher vascular density in the embryonic quail CAM. The response observed at 2 and 5 days post-treatment was equivalent to that achieved by applying 10 mg mL À1 of basic fibroblast growth factor. These results show that the ionic dissolution products released from the bioactive glass 45S5.2B stimulate angiogenesis in vivo. The effects observed are attributed to the presence the ionic dissolution products, which contained 160 AE 10 mM borate.

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“…During the last decade, metallic ions such as boron, copper, lithium, gallium, silver, strontium, cerium, cobalt and zinc, among others, have emerged as potential therapeutic agents with the ability to enhance bone formation by their stimulating effects on osteogenesis and angiogenesis [11,12]. In recent studies, new compositions of mesoporous materials including the addition of therapeutic ions have been suggested in order to increase the materials' functionality and biological activity, particularly for applications in large-size bone defects, which are a significant clinical challenge [8].…”

Section: Introductionmentioning

confidence: 99%

Novel ion-doped mesoporous glasses for bone tissue engineering: Study of their structural characteristics influenced by the presence of phosphorous oxide

Philippart

Gómez-Cerezo

Arcos

et al. 2017

Journal of Non-Crystalline Solids

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Ion-doped binary SiO 2 -CaO and ternary SiO 2 -CaO-P 2 O 5 mesoporous bioactive glasses were synthesised and characterised to evaluate the influence of P 2 O 5 in the glass network structure.Strontium, copper and cobalt oxides in a proportion of 0.8 mol% were selected as dopants because the osteogenic and angiogenic properties reported for these elements. Although the four glass compositions investigated presented analogous textural properties, TEM analysis revealed that the structure of those containing P 2 O 5 exhibited an increased ordered mesoporosity. Furthermore, 29 Si NMR revealed that the incorporation of P 2 O 5 increased the network connectivity and that this compound captured the Sr 2+, Cu 2+ and Co 2+ ions preventing them to behave as modifiers of the silica network. In addition, 31 P NMR results revealed that the nature of the cation directly influences the characteristics of the phosphate clusters. In this study, we have proven that phosphorous oxide entraps doping-metallic ions, granting these glasses with a greater mesopores order.

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Therapeutic inorganic ions in bioactive glasses to enhance bone formation and beyond

Cited by 174 publications

References 41 publications

Glasses in bone regeneration: A multiscale issue

Glasses in bone regeneration: A multiscale issue

Angiogenic effects of ionic dissolution products released from a boron-doped 45S5 bioactive glass

Novel ion-doped mesoporous glasses for bone tissue engineering: Study of their structural characteristics influenced by the presence of phosphorous oxide

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