Therapeutic indications, chemical composition and biological activity of native Brazilian species from Psidium genus (Myrtaceae): A review

Macedo, Julimery Gonçalves Ferreira; Rangel, Juliana Melo Linhares; Santos, Maria de Oliveira; Camilo, Cicera Janaíne; Costa, José Galberto Martins da; Souza, Marta Maria de Almeida

doi:10.1016/j.jep.2021.114248

Cited by 15 publications

(3 citation statements)

References 80 publications

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“…Accesses Mean value Minimum and maximum value 2C value I Gua (6) , Gua (17) , Gua (31) , Mac (1) , Obl (1) 0.96 0.90 -1.10 II Aci (4) , Cat (1) , Hib (14) , Gui (7) , Psi (7) 1.94 1.80 -2.08 III Cat (19) , Cat (11) , Cat (5) , Cat (30) , Cat (30) , Myr (6) , Myr (18) , Myr (30) , Ruf (1) , Psi (1) 3.51 2.72 -4.38 IV Cat (5) , Gau (1) , Gau (28) ,Fri (1) , Psi (3) 4.88 4.47 -5.19…”

Section: Groupmentioning

confidence: 99%

“…Leaf essential oils, characteristic of the Myrtaceae family secondary metabolism, are rich in terpene and exhibit quali- and quantitative variations reported 24 . Terpenes play ecological roles, and essential oils are economically exploited 25 – 27 for their biological and phytotherapeutic activities 28 . Our research group evidenced that seven P. cattleyanum plants exhibited different nuclear 2C values (2C = 3.20 pg – 2C = 6.03 pg), seven monoterpenes and eight sesquiterpenes in essential oils.…”

Section: Introductionmentioning

confidence: 99%

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Genomic and epigenomic variation in Psidium species and their outcome under the yield and composition of essential oils

Silva

Soares

Clarindo

et al. 2023

Sci Rep

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Diploid and polyploid species derived from the euploid series x = 11 occur in the genus Psidium, as well as intraspecific cytotypes. Euploidy in the genus can alter the gene copy number, resulting in several “omics” variations. We revisited the euploidy, reported genomic (nuclear 2C value, GC%, and copy number of secondary metabolism genes) and epigenomic (5-mC%) differences in Psidium, and related them to essential oil yield and composition. Mean 2C values ranged from 0.90 pg (P. guajava) to 7.40 pg (P. gaudichaudianum). 2C value is intraspecifically varied in P. cattleyanum and P. gaudichaudianum, evidencing cytotypes that can be formed from euploid (non-reduced) and/or aneuploid reproductive cells. GC% ranged from 34.33% (P. guineense) to 48.95% (P. myrtoides), and intraspecific variations occurred even for species without 2C value intraspecific variation. Essential oil yield increased in relation to 2C value and to GC%. We showed that P. guajava (diploid) possesses two and P. guineense (tetraploid) four copies of the one specific TPS gene, as well as eight and sixteen copies respectively of the conserved regions that occur in eight TPS genes. We provide a wide “omics'' characterization of Psidium and show the outcome of the genome and epigenome variation in secondary metabolism.

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Section: Groupmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genomic and epigenomic variation in Psidium species and their outcome under the yield and composition of essential oils

Silva

Soares

Clarindo

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…[3][4][5] In addition to being used in food, this species is used in folk medicine to treat influenza, corroborating the evidence that this plant could be helpful in natural product research targeting inflammatory processes. [6] Importantly, acute toxicity studies [5] revealed that P. brownianum essential oil showed no signs of toxicity (LD 50 � 2,000 mg/Kg) when administered orally to rodents. Furthermore, this species can be used in doses corresponding to less than 10 % of the LD 50 , making its use relatively safe.…”

Section: Introductionmentioning

confidence: 99%

Topical Antiedematogenic Activity of the Essential Oil of Psidium brownianum Mart. (OEPB) in Murine Ear Edema Models

de Souza Sampaio,

Brito Pereira Bezerra Martins,

Santos da Silva

et al. 2024

Chemistry & Biodiversity

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Psidium brownianum Mart is reported in the literature by antinociceptive and antioxidant activities, indicating that this species' secondary metabolites might be used to control inflammatory processes. The present study aimed to characterize the topical antiedematogenic activity of the essential oil of Psidium brownianum Mart. (OEPB) in ear edema models by different inflammatory agents. Female Swiss mice (25‐35g) and Wistar albino rats (200‐300g) were used throughout tests (n=6/group) on acute or chronic edema models induced by single and multiple topical applications. The OEPB is administered topically pure or at a concentration of 100 or 200 mg/mL. The antiedematogenic mechanism of OEPB was analyzed by administering capsaicin, arachidonic acid, histamine, and phenol at the best effective dose (200 mg/mL). The results showed a significant reduction of edema‐induced single (28.87%) and multiple (50.13%) applications of croton oil compared to the negative control group. Regarding potential mechanisms of action, OEPB (200 mg/mL) inhibited the development of edema triggered by capsaicin (29.95%), arachidonic acid (22.66%), phenol (23.35%), and histamine (75.46%), suggesting an interference with the histaminergic pathway. These results indicate that OEPB presents a topical antiedematogenic effect in acute and chronic murine models, possibly interfering with inflammatory pathways triggered by mediators such as histamine.

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Essential oil from the leaves of Eugenia pohliana DC. (Myrtaceae) alleviate nociception and acute inflammation in mice

et al. 2022

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Therapeutic indications, chemical composition and biological activity of native Brazilian species from Psidium genus (Myrtaceae): A review

Cited by 15 publications

References 80 publications

Genomic and epigenomic variation in Psidium species and their outcome under the yield and composition of essential oils

Genomic and epigenomic variation in Psidium species and their outcome under the yield and composition of essential oils

Topical Antiedematogenic Activity of the Essential Oil of Psidium brownianum Mart. (OEPB) in Murine Ear Edema Models

Essential oil from the leaves of Eugenia pohliana DC. (Myrtaceae) alleviate nociception and acute inflammation in mice

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