Therapeutic implications of quercetin and its derived-products in COVID-19 protection and prophylactic

Ho, Wan-Yi; Shen, Zi-han; Chen, Yijing; Chen, Ting-Hsu; Lu, XiaoLin; Fu, Yaw-Syan

doi:10.1016/j.heliyon.2024.e30080

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e30080

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Therapeutic implications of quercetin and its derived-products in COVID-19 protection and prophylactic

Wan-Yi Ho,

Zi-han Shen,

Yijing Chen

et al.

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2024

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Cited by 2 publications

References 165 publications

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Alliaceae-Derived Supplementation Improves the Severity of COVID-19 Symptoms among Elderly Nursing Home Residents

Vázquez-Blanquiño,

Pérez-Rodríguez,

Alberola-Romano

et al. 2024

Foods

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This study investigates the effect of daily consumption of a concentrated garlic and onion extract on COVID-19 symptoms among elderly nursing home residents. Volunteers consumed a daily capsule of the concentrated powder rich in organosulfur compounds over 36 weeks during lunch. The incidence and severity of COVID-19 symptoms between the treatment and control groups were compared, along with monitoring the safety of consumption, incidence of other diseases, and medicine usage. The treatment group showed a significant reduction in both the number and severity of COVID-19 symptoms compared to the control group, with no significant adverse effects observed. No significant reduction in symptom duration was detected. This study provides preliminary evidence that concentrated garlic and onion extract may aid in the treatment of COVID-19 among older adults. These findings suggest potential public health benefits, emphasizing the need for further research to explore the immunomodulatory properties of these natural compounds.

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Alliaceae-Derived Supplementation Improves the Severity of COVID-19 Symptoms among Elderly Nursing Home Residents

Vázquez-Blanquiño,

Pérez-Rodríguez,

Alberola-Romano

et al. 2024

Foods

View full text Add to dashboard Cite

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Antiviral Properties of Moringa oleifera Leaf Extracts against Respiratory Viruses

Giugliano,

Ferraro,

Chianese

et al. 2024

Viruses

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Moringa oleifera (M. oleifera) is a plant widely used for its beneficial properties both in medical and non-medical fields. Because they produce bioactive metabolites, plants are a major resource for drug discovery. In this study, two different cultivars of leaves of M. oleifera (Salento and Barletta) were obtained by maceration or microwave-assisted extraction (MAE). We demonstrated that extracts obtained by MAE exhibited a lower cytotoxic profile compared to those obtained by maceration at concentrations ranged from 25 to 400 µg/mL, on both Vero CCL-81 and Vero/SLAM cells. We examined their antiviral properties against two viruses, i.e., the human coronavirus 229E (HCoV-229E) and measles virus (MeV), which are both responsible for respiratory infections. The extracts were able to inhibit the infection of both viruses and strongly prevented their attack and entry into the cells in a range of concentrations from 50 to 12 µg/mL. Particularly active was the variety of Salento that registered a 50% inhibitory concentration (IC50) at 21 µg/mL for HCoV-229E and at 6 µg/mL for MeV. We identified the presence of several compounds through high performance liquid chromatography (HPLC); in particular, chlorogenic and neochlorogenic acids, quercetin 3-O-β-D-glucopyranoside (QGP), and glucomoringin (GM) were mainly observed. In the end, M. oleifera can be considered a promising candidate for combating viral infections with a very strong action in the early stages of viral life cycle, probably by destructuring the viral particles blocking the virus–cell fusion.

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Therapeutic implications of quercetin and its derived-products in COVID-19 protection and prophylactic

Cited by 2 publications

References 165 publications

Alliaceae-Derived Supplementation Improves the Severity of COVID-19 Symptoms among Elderly Nursing Home Residents

Alliaceae-Derived Supplementation Improves the Severity of COVID-19 Symptoms among Elderly Nursing Home Residents

Antiviral Properties of Moringa oleifera Leaf Extracts against Respiratory Viruses

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