Therapeutic implications of prion diseases

Chen, Cao; Dong, Xiao‐Ping

doi:10.1016/j.bsheal.2020.09.001

Cited by 16 publications

(33 citation statements)

References 122 publications

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“…Whereas, iron tetrapyrole derivative Fe(III) and its strongly same type of porphyrins predicts the increase in survival activity in prion-diseased mice 5 . Fe(III)-TMPyP combines to PrP c produces the two type of effects 5 . (Blocks the prion duplication and also stops the activity of PrP intervened toxicity) 5 .…”

Section: Iron Tetrapyrole Derivative Fe(iii) -Tmpyp Interact Withmentioning

confidence: 99%

“…In an experiment ,the mice is taken and injects with PPS in the cerebral ventricles in prion diseased mouse, PPS shows activity of 5 increment or increase the lag phase of diseased mice. After treatment with PPS their is no significance or no reversal of foregoing neurological deficit are experiential 5 .…”

Section: Approaches For Treatment Of Prion or Prion Diseasementioning

confidence: 99%

“…Pentosan Polysulphate(PPS) is a type of polyglycoside 5 chemical compound having low heparin-like 5 work. Pentosan polysulphate acts as a co-receptor for prion type of protein(PrP) on cell area 5 when compared to interior heparin sulfate proteoglycans and this PPS predicts the better capacity to stop the making of newly maked PrP sc in neuroblastoma cells 5 or cancerous cell(tumor cell). In an experiment ,the mice is taken and injects with PPS in the cerebral ventricles in prion diseased mouse, PPS shows activity of 5 increment or increase the lag phase of diseased mice.…”

Section: Approaches For Treatment Of Prion or Prion Diseasementioning

confidence: 99%

“…Many researches describe that patients with CJD received the doxycycline, which results that, exhibit longer survival time, when compared to other patient which are not receive doxycycline. But, during doxycycline is orally administer in patients (100mg) does not predicts or profit the continued existence of patient with creutzfeldt-jakob disease 5 .…”

Section: Approaches For Treatment Of Prion or Prion Diseasementioning

confidence: 99%

“…the PrP c and Fe(III0-TMPyP works just like therapeutic chaperone for prion protein cellular,that reduces the ground state of the occupant conformation and 5 shows the activity of inhibition in prion-induced unusual folding in vitro. Whereas, iron tetrapyrole derivative Fe(III) and its strongly same type of porphyrins predicts the increase in survival activity in prion-diseased mice 5 . Fe(III)-TMPyP combines to PrP c produces the two type of effects 5 .…”

Section: Iron Tetrapyrole Derivative Fe(iii) -Tmpyp Interact Withmentioning

confidence: 99%

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A Review on Protein Misfolding Diseases and therapeutics for preventing Diseases

Singh

2021

J. Drug Delivery Ther.

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Background: Protein misfolding sicknesses are the gathering of irresistible lethal neuro and non-neurodegenerative infections and in ebb and flow researchers and specialists accepted that unusual folding of protein is the essential or main key of such illnesses are Alzheimer's infections, Parkinson's diseases, Huntington's sickness, Creutzfeldt-Jakob infection, cystic fibrosis, Gaucher's infection and numerous other degenerative and neurodegenerative problems. The motive of this review article is to gave a detailed of the existing structural information for prion and prion protein and also we will trying to find out their preventing root causes with respect to structural information of prions within the context of what is known about the protein misfolding diseases. Objective: This article presents a brief overview of research on the use of these therapeutics for the treatment or improvement in prion diseases or protein misfolding. Material and Methods: This article begins with the brief introduction about protein misfolding diseases or infections and the therapeutic materials which are used in researches or explain this article (pentosan polysulfate, Quinacrine, Doxycycline, Chaperone based therapy, Resveratrol and curcumin) etc. Results and Conclusions: In this present context of protein misfolding/prion diseases diagonsis.Therapeutic approaches predicts that person infected with prion diseases prolongs the survival time of the patient and improvement in the conditions of the prion diseased infected patient which provides good result for future medicine development. Keywords: Amyloid, Beta-sheet, neurodegenerative, prion, protein misfolding, therapeutics etc

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Section: Iron Tetrapyrole Derivative Fe(iii) -Tmpyp Interact Withmentioning

confidence: 99%

Section: Approaches For Treatment Of Prion or Prion Diseasementioning

confidence: 99%