Therapeutic Implications of Nanopharmaceuticals in Skin Delivery

Mota, Ana Henriques; Santos-Rebelo, Ana; Almeida, António J.; Reis, Catarina Pinto

doi:10.1007/978-3-030-44925-4_6

Cited by 2 publications

(4 citation statements)

References 273 publications

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“…Nanotechnology was used to increase the stability of active compounds, to modulate their release, as well as to improve the solubility of poorly water-soluble compounds [1,32,33]. Thus, two different polymeric NPs for skin delivery were selected: PLGA and PCL NPs polymers [12,34].…”

Section: Characterization Of Nanoparticlesmentioning

confidence: 99%

Further Evidence of Possible Therapeutic Uses of Sambucus nigra L. Extracts by the Assessment of the In Vitro and In Vivo Anti-Inflammatory Properties of Its PLGA and PCL-Based Nanoformulations

et al. 2020

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Sambucus nigra L. is widely used in traditional medicine with different applications. However, confirmative studies are strongly required. This study aimed to assess the biological activities of the S. nigra flower’s extract encapsulated into two different types of nanoparticles for optimizing its properties and producing further evidence of its potential therapeutic uses. Different nanoparticles (poly(lactide-co-glycolide, PLGA) and poly-Ɛ-caprolactone (PCL), both with oleic acid, were prepared by emulsification/solvent diffusion and solvent-displacement methods, respectively. Oleic acid was used as a capping agent. After the nanoparticles’ preparation, they were characterized and the biological activities were studied in terms of collagenase, in vitro and in vivo anti-inflammatory, and in vitro cell viability. Rutin and naringenin were found to be the major phenolic compounds in the studied extract. The encapsulation efficiency was higher than 76% and revealed to have an impact on the release of the extract, mainly for the PLGA. Moreover, biochemical and histopathological analyses confirmed that the extract-loaded PLGA-based nanoparticles displayed the highest anti-inflammatory activity. In addition to supporting the previously reported evidence of potential therapeutic uses of S. nigra, these results could draw the pharmaceutical industry’s interest to the novelty of the nanoproducts.

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Section: Characterization Of Nanoparticlesmentioning

confidence: 99%

Further Evidence of Possible Therapeutic Uses of Sambucus nigra L. Extracts by the Assessment of the In Vitro and In Vivo Anti-Inflammatory Properties of Its PLGA and PCL-Based Nanoformulations

et al. 2020

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“…It presents three different layers (epidermis, dermis and hypodermis). The epidermis in turn can be divided in distinct layers: stratum corneum, lucidum, granulosum, spinosum and basale [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…These factors are associated with ultrastructural anomalies in the upper granular layer [ 1 ], related to a change of integrity of the skin layers and respective structures. These disorders can appear due to many factors, underlying medical conditions and other pathologies, such as inflamed skin, infections, chronic inflammatory skin disorders (e.g., psoriasis), sensitive skin (e.g., allergic contact dermatitis, atopic dermatitis, seborrhea dermatitis or rosacea), among others [ 1 ]. Inflamed skin is generally characterized by redness, swelling, itching, heat and pain [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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A Newfangled Collagenase Inhibitor Topical Formulation Based on Ethosomes with Sambucus nigra L. Extract

et al. 2021

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Sambucus nigra L. (S. nigra) is a shrub widespread in Europe and western Asia, traditionally used in medicine, that has become popular in recent years as a potential source of a wide range of interesting bioactive compounds. The aim of the present work was to develop a topical S. nigra extract formulation based on ethosomes and thus to support its health claims with scientific evidence. S. nigra extract was prepared by an ultrasound-assisted method and then included in ethosomes. The ethosomes were analyzed in terms of their size, stability over time, morphology, entrapment capacity (EC), extract release profile, stability over time and several biological activities. The prepared ethosomes were indicated to be well defined, presenting sizes around 600 nm. The extract entrapment capacity in ethosomes was 73.9 ± 24.8%, with an interesting slow extract release profile over 24 h. The extract-loaded ethosomes presented collagenase inhibition activity and a very good skin compatibility after human application. This study demonstrates the potential use of S. nigra extract incorporated in ethosomes as a potential cosmeceutical ingredient and on further studies should be performed to better understand the impact of S. nigra compounds on skin care over the time.

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Therapeutic Implications of Nanopharmaceuticals in Skin Delivery

Cited by 2 publications

References 273 publications

Further Evidence of Possible Therapeutic Uses of Sambucus nigra L. Extracts by the Assessment of the In Vitro and In Vivo Anti-Inflammatory Properties of Its PLGA and PCL-Based Nanoformulations

Further Evidence of Possible Therapeutic Uses of Sambucus nigra L. Extracts by the Assessment of the In Vitro and In Vivo Anti-Inflammatory Properties of Its PLGA and PCL-Based Nanoformulations

A Newfangled Collagenase Inhibitor Topical Formulation Based on Ethosomes with Sambucus nigra L. Extract

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