Therapeutic Implications of Drug Interactions With Acetaminophen and Aspirin

Hayes, Arthur H.

doi:10.1001/archinte.1981.00340030033007

Cited by 20 publications

(7 citation statements)

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“…As perpetrators, penicillins may reduce the disposition of oral contraceptives [ 24 ], however, this pDDI is unlikely to be of clinical relevance in the ICU setting. Penicillins may also reduce the renal excretion of methotrexate resulting in increased systemic exposure, whereas concomitant administration of probenecid or non-steroidal anti-inflammatory agents may increase the exposure of penicillins [ 25 , 26 , 27 ]. Also in these cases, the clinical relevance of these pDDIs in ICU may be questionable.…”

Section: Antibiotics As Victims or Perpetrators Of Pddismentioning

confidence: 99%

“…The potential of cephalosporins to cause or to be victims of pDDIs is very similar to what has been already described for penicillins;many molecules of this class are unlikely to cause DDIs. Conversely, the bioavailability of most molecules of this class can be significantly increased by concomitant probenecid administration [ 25 , 26 , 27 ].…”

Section: Antibiotics As Victims or Perpetrators Of Pddismentioning

confidence: 99%

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The Issue of Pharmacokinetic-Driven Drug-Drug Interactions of Antibiotics: A Narrative Review

Cattaneo

Gervasoni

Corona³

2022

Antibiotics

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Patients in intensive care units (ICU) are at high risk to experience potential drug-drug interactions (pDDIs) because of the complexity of their drug regimens. Such pDDIs may be driven by pharmacokinetic or pharmacodynamic mechanisms with clinically relevant consequences in terms of treatment failure or development of drug-related adverse events. The aim of this paper is to review the pharmacokinetic-driven pDDIs involving antibiotics in ICU adult patients. A MEDLINE Pubmed search for articles published from January 2000 to June 2022 was completed matching the terms “drug-drug interactions” with “pharmacokinetics”, “antibiotics”, and “ICU” or “critically-ill patients”. Moreover, additional studies were identified from the reference list of retrieved articles. Some important pharmacokinetic pDDIs involving antibiotics as victims or perpetrators have been identified, although not specifically in the ICU settings. Remarkably, most of them relate to the older antibiotics whereas novel molecules seem to be associated with a low potential for pDDIs with the exceptions of oritavancin as potential perpetrator, and eravacicline that may be a victim of strong CYP3A inducers. Personalized therapeutic drug regimens by means of available web-based pDDI checkers, eventually combined with therapeutic drug monitoring, when available, have the potential to improve the response of ICU patients to antibiotic therapies.

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Section: Antibiotics As Victims or Perpetrators Of Pddismentioning

confidence: 99%

Section: Antibiotics As Victims or Perpetrators Of Pddismentioning

confidence: 99%

The Issue of Pharmacokinetic-Driven Drug-Drug Interactions of Antibiotics: A Narrative Review

Cattaneo

Gervasoni

Corona³

2022

Antibiotics

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“…These drugs (NSAIDs) displace other pharmacologic agents from plasma protein-binding sites resulting in an increase in the fraction of circulating free drug [ 167,168 ] . By this mechanism, indomethacin and other NSAIDs may increase the toxicity of methotrexate, sulfonylurea, hypoglycemic drugs, and phenytoin [167][168][169][170][171][172][173][174][175][176][177][178] . On the other hand, indomethacin protein binding is decreased by ibuprofen (Motrin) [ 179 ] .…”

Section: Other Toxicities Of Nsaidsmentioning

confidence: 99%

Management of Hyperuricemia and Gout

Newcombe¹

2012

Gout

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“…Common drugs that delay gastric emptying time and interact with acetaminophen include propantheline bromide and narcotic analgesics. A study of a small series of patients demonstrated that propantheline reduces the rate of absorption of acetaminophen but not the absolute amount absorbed 24 . For analgesic drugs, a delay in the rate of absorption or lowering of the peak concentration reached could diminish therapeutic efficacy, but this is probably not clinically relevant.…”

Section: Drug–drug Interactionsmentioning

confidence: 99%

“…However, in a recent survey of 45 adult patients with chronic active hepatitis, Neuberger and associates found no evidence to implicate this drug 49 . Chronic alcoholics may be pre‐disposed to hepatotoxicity in the event of significant acute acetaminophen overdosage, but acute alcohol ingestion may decrease toxicity 24 …”

Section: Side Effects and Toxicitymentioning

confidence: 99%

The Use of Non‐prescription Analgesics in an Older Population

Cupit¹

1982

J American Geriatrics Society

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Older patients are frequent users of aspirin and acetaminophen, either recommended by physicians or self‐prescribed, for the aches and pains that accompany aging. These mild analgesics provide effective pain relief when used appropriately. Aspirin and acetaminophen are equianalgesic on a milligram‐for‐milligram basis for most indications. Both are safe for most patients. Aspirin use may be associated with salicylate intoxication or salicylate interactions with other agents. There have been reports of an association of hepatotoxicity with acute massive overdosages of acetaminophen.

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Therapeutic Implications of Drug Interactions With Acetaminophen and Aspirin

Cited by 20 publications

References 0 publications

The Issue of Pharmacokinetic-Driven Drug-Drug Interactions of Antibiotics: A Narrative Review

The Issue of Pharmacokinetic-Driven Drug-Drug Interactions of Antibiotics: A Narrative Review

Management of Hyperuricemia and Gout

The Use of Non‐prescription Analgesics in an Older Population

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