Therapeutic hypothermia in term infants after perinatal encephalopathy: The last 5years in Switzerland

The impact of a register on the management of neonatal cooling in Switzerland

“…Passively cooled newborn infants showed also a lot of temperature measurements below target temperature range. Passive cooling is known to be the least reliable of the cooling methods when it comes to temperature variability and keeping the newborn infants within target range [4,11,12]. Although more temperature measurements were below the target range during the second time period, fewer newborn infants were severely overcooled in the second time period compared to the first time period.…”

“…Retrospective analysis of all cooled newborn infants prior to the register showed that most newborn infants were cooled passively, and those showed higher temperature variability than those cooled actively. In addition, the criteria for cooling were poorly documented and neuromonitoring did not comply with international standards [4].…”

Therapeutic Hypothermia in Asphyxiated Neonates with Hypoxic-ischemic Encephalopathy: A single-center Experience from its First Application in Saudi Arabia

“…Infant Cooling Evaluation Collaboration (ICE study) clinical trial has reported that whole body cooling using low tech methods was safe and effective for HIE cases. Owing to its practicality and low cost, it is used by several centers even in high resource countries [14,22,23] . Still, one should be aware of the highest variation of temperature with this cooling method [14] .…”

“…In Europe, therapeutic hypothermia is already achieved in several countries as well. This because the participation of some medical centers in clinical trials such as: TOBY; in the United Kingtom, neo.nEURO; in Germany and in several European countries , while in others its use is expanding rapidly [11][12][13][14][15] .…”

Prevalence and etiology of false normal aEEG recordings in neonatal hypoxic-ischaemic encephalopathy

“…Recent clinical trials have provided clear evidence that therapeutic hypothermia initiated before six hours of age improves the neurological outcome in neonates with moderate hypoxic-ischemic encephalopathy (HIE) [1-4]. The early identification of neonates who may benefit from therapeutic hypothermia is of great importance.…”