Therapeutic Hypothermia in Post-Cardiac Arrest and Myocardial Infarction

Polderman, Kees H.; Noč, Marko; Kurz, Michael C.; Aibiki, Mayuki

doi:10.1089/ther.2015.29005.kjp

Cited by 9 publications

(2 citation statements)

References 16 publications

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“…As for the underlying mechanisms about reperfusion injury, myocardial damages resulted from restoring epicardial coronary blood flow, are multifactorial and not fully understood to date. 29 35 36 37 TH is one of the promising strategies to prevent reperfusion injury, 20 38 and we focused TH and its mechanism for cardioprotection in this review.…”

Section: Rationale For Mild Hypothermiamentioning

confidence: 99%

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Therapeutic Hypothermia for Cardioprotection in Acute Myocardial Infarction

2016

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Mild therapeutic hypothermia of 32–35℃ improved neurologic outcomes in outside hospital cardiac arrest survivor. Furthermore, in experimental studies on infarcted model and pilot studies on conscious patients with acute myocardial infarction, therapeutic hypothermia successfully reduced infarct size and microvascular resistance. Therefore, mild therapeutic hypothermia has received an attention as a promising solution for reduction of infarction size after acute myocardial infarction which are not completely solved despite of optimal reperfusion therapy. Nevertheless, the results from randomized clinical trials failed to prove the cardioprotective effects of therapeutic hypothermia or showed beneficial effects only in limited subgroups. In this article, we reviewed rationale for therapeutic hypothermia and possible mechanisms from previous studies, effective methods for clinical application to the patients with acute myocardial infarction, lessons from current clinical trials and future directions.

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Section: Rationale For Mild Hypothermiamentioning

confidence: 99%

“… 46 47 48 To attenuate reperfusion injury and microvascular alteration, maintenance of TH after revascularization is an another important issue needed to be addressed. 15 16 38 …”

Section: Timing Speed and Durationmentioning

confidence: 99%