Therapeutic hypothermia for out-of-hospital cardiac arrest

Lee, Rozalynne; Asare, Kwame Kumi

doi:10.2146/ajhp090626

Cited by 26 publications

(28 citation statements)

References 74 publications

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“…Hypothermia is used clinically to promote neuronal survival in cardiac surgery and after cardiac arrest [63] by decreasing metabolic rate, reducing tissue oxygen consumption, depressing metabolic acidosis [64], suppressing calcium influx into neurons [65], and diminishing nitric oxide production [66]. Similar protective effects have been described during cochlear implantation, noise trauma and ischemic cochlear injury [67–71].…”

Section: Potential Causes Of Hearing Loss Following Cochlear Implamentioning

confidence: 99%

“…Safe hypothermic induction can be noninvasive by using cooling blankets and ice packs, or a more invasive route can involve safe infusion of large volumes of cold fluids [63]. Hypothermia is used clinically to promote neuronal survival in cardiac surgery and after cardiac arrest [63] by decreasing metabolic rate, reducing tissue oxygen consumption, depressing metabolic acidosis [64], suppressing calcium influx into neurons [65], and diminishing nitric oxide production [66].…”

Section: Potential Causes Of Hearing Loss Following Cochlear Implamentioning

confidence: 99%

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Electroacoustic Stimulation: Now and into the Future

Irving

Gillespie

Richardson

et al. 2014

BioMed Research International

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Cochlear implants have provided hearing to hundreds of thousands of profoundly deaf people around the world. Recently, the eligibility criteria for cochlear implantation have been relaxed to include individuals who have some useful residual hearing. These recipients receive inputs from both electric and acoustic stimulation (EAS). Implant recipients who can combine these hearing modalities demonstrate pronounced benefit in speech perception, listening in background noise, and music appreciation over implant recipients that rely on electrical stimulation alone. The mechanisms bestowing this benefit are unknown, but it is likely that interaction of the electric and acoustic signals in the auditory pathway plays a role. Protection of residual hearing both during and following cochlear implantation is critical for EAS. A number of surgical refinements have been implemented to protect residual hearing, and the development of hearing-protective drug and gene therapies is promising for EAS recipients. This review outlines the current field of EAS, with a focus on interactions that are observed between these modalities in animal models. It also outlines current trends in EAS surgery and gives an overview of the drug and gene therapies that are clinically translatable and may one day provide protection of residual hearing for cochlear implant recipients.

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Section: Potential Causes Of Hearing Loss Following Cochlear Implamentioning

confidence: 99%

Section: Potential Causes Of Hearing Loss Following Cochlear Implamentioning

confidence: 99%

Electroacoustic Stimulation: Now and into the Future

Irving

Gillespie

Richardson

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Another problem with surface cooling is cold injury, causing pressure ulcers and Therapeutic Hypothermia in Brain Injury 6 skin breakdown. Surface cooling is less efficient in reducing the temperature of target organs, such as the brain and heart 6 Invasive cooling 30 ml/kg Lactated Ringers solution that has been chilled to 4°C can be infused over 30 minutes. No adverse effects of the rapid infusion of this volume of IV crystalloid fluid in a study by Bernard.…”

Section: Surface Cooling: Dine Et Almentioning

confidence: 99%

“…Clinically significant cardiac arrhythmias occurred with less frequency in the Australian study compared to the European study, where no lidocaine was employed. 6 Coronary blood flow has been shown to decrease during mild hypothermia in patients with coronary artery disease. Evidence from animal studies has shown a 10% reduction in myocardial infarct size for every 1°C decrease in body temperature.…”

Section: Cardiovascular Manifestationsmentioning

confidence: 99%

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Therapeutic Hypothermia: Adverse Events, Recognition, Prevention and Treatment Strategies

Lakshmanan¹,

Sadaka²,

Palagiri³

2013

Therapeutic Hypothermia in Brain Injury

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State‐of‐the‐art paper: Therapeutic hypothermia in out of hospital cardiac arrest survivors

Alkadri

Peters

Katz

et al. 2013

Cathet Cardio Intervent

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Out of hospital cardiac arrest (OHCA) is associated with an extremely poor survival rate, with mortality in most cases being related to neurological injury. Among patients who experience return of spontaneous circulation (ROSC), therapeutic hypothermia (TH) is the only proven intervention shown to reduce mortality and improve neurological outcome. First described in 1958, the field of TH has rapidly evolved in recent years. While recent technological advances in TH will likely improve outcomes in OHCA survivors, several fundamental questions remain to be answered including the optimal speed of cooling, which patients benefit from an early invasive strategy, and whether technological advances will facilitate application of TH in the field. An increased awareness and understanding of TH strategies, devices, monitoring, techniques, and complications will allow for a more widespread adoption of this important treatment modality.

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Therapeutic hypothermia for out-of-hospital cardiac arrest

Abstract: TH is an effective strategy for improving neurologic outcomes of patients after out-of-hospital cardiac arrest due to VF. Further studies are needed to confirm the optimal time and methods for cooling to maximize the chance of complete neurologic recovery after cardiac arrest.

Cited by 26 publications

References 74 publications

Electroacoustic Stimulation: Now and into the Future

Electroacoustic Stimulation: Now and into the Future

Therapeutic Hypothermia: Adverse Events, Recognition, Prevention and Treatment Strategies

State‐of‐the‐art paper: Therapeutic hypothermia in out of hospital cardiac arrest survivors

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