Therapeutic Hypothermia for Neonatal Encephalopathy in Low-Resource Settings: Methodological Inaccuracies and Inconsistencies in the Latest Systematic Review

Mathew, Joseph L; Kaur, Navneet; Dsouza, Jeanne Maria

doi:10.1159/000526596

Cited by 2 publications

(3 citation statements)

References 15 publications

(17 reference statements)

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“…Hypothermia is defined as a central or axillary temperature below 36.5°C 1,2 . It is relatively common in preterm and low birth weight infants following birth and admission to neonatal intensive care .…”

Section: Introductionmentioning

confidence: 99%

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Hypothermia is defined as a central or axillary temperature below 36.5°C. 1,2 It is relatively common in preterm and low birth weight infants following birth and admission to neonatal intensive care . The incidence of hypothermia was between 31% and 78% in infants with birth weight less than 1500 g. 3 Hypothermia is associated with numerous complications in preterm infants, such as impaired glucose metabolism, impaired immune function and deranged coagulation.

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confidence: 99%

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Hypothermia and adverse outcomes during the transfer of extremely low birth weight infants

Ogunna,

Mohinuddin,

Ratnavel

et al. 2023

Acta Paediatrica

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AimWe aimed to explore whether hypothermia during the transfer of extremely low birth weight (ELBW) infants was associated with increased morbidity and mortality.MethodsRetrospective cohort study of transfers of ELBW infants by the London Neonatal Transfer Service between April 2015 and January 2017. Hypothermia was defined as an axillary temperature below 36.5°C.ResultsHypothermia was recorded in 36–47% of the 146 transfers depending on the time point of measurement from admission at the referring unit to admission at the receiving unit. Infants with hypothermia had a lower gestational age [25.1 (24.1–26.6) versus 26.0 (25.3–27.0) weeks, p < 0.001], birth weight [750 (600–830) versus 800 (730–885) gr, p = 0.004) and age at referral [1 (0.8–3) versus 1.5 (1–4) hours, p = 0.049] compared to infants without hypothermia. Infants with hypothermia had a longer median (IQR) duration of invasive ventilation [22(6–44) days] compared to infants without hypothermia [10 (4–21) days, p = 0.002]. Infants with hypothermia had a higher incidence of a patent ductus arteriosus and mortality before discharge from neonatal care compared to infants without hypothermia (79% vs. 27%, p = 0.043 and 29% vs. 13%, p = 0.025, respectively).ConclusionAmong ELBW infants, hypothermia during transfer was common, particularly in infants of lower gestational age. Hypothermia was associated with a longer duration of ventilation and increased mortality before discharge from neonatal care.

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Section: Introductionmentioning

confidence: 99%

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mentioning

confidence: 99%

Hypothermia and adverse outcomes during the transfer of extremely low birth weight infants

Ogunna,

Mohinuddin,

Ratnavel

et al. 2023

Acta Paediatrica

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show abstract

“…We read with interest the letter of Mathew et al [1], raising some concerns about the methodology of our recent meta-analysis entitled: “Therapeutic Hypothermia for Neonatal Encephalopathy in Low- and Middle-Income Countries: A Meta-Analysis” [2]. Below, we provide the reply to the comments concerning our publication.…”

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Response to Letter “Therapeutic Hypothermia for Neonatal Encephalopathy in Low-Resource Settings: Methodological Inaccuracies and Inconsistencies in the Latest Systematic Review”

Bellos

Pandita

2023

Neonatology

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Therapeutic Hypothermia for Neonatal Encephalopathy in Low-Resource Settings: Methodological Inaccuracies and Inconsistencies in the Latest Systematic Review

Cited by 2 publications

References 15 publications

Hypothermia and adverse outcomes during the transfer of extremely low birth weight infants

Hypothermia and adverse outcomes during the transfer of extremely low birth weight infants

Response to Letter “Therapeutic Hypothermia for Neonatal Encephalopathy in Low-Resource Settings: Methodological Inaccuracies and Inconsistencies in the Latest Systematic Review”

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