Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children

Abstract

BACKGROUND-Targeted temperature management is recommended for comatose adults and children after out-of-hospital cardiac arrest; however, data on temperature management after inhospital cardiac arrest are limited.

Focus on paediatrics: 2017

“…In 2017, the long-awaited results of the therapeutic hypothermia after in-hospital cardiac arrest were published [18]. Similar to the previously reported out-of-hospital THAPCA trial, there was no benefit for moderate hypothermia compared to controlled normothermia on survival with a good neurobehavioral outcome.…”

Targeted Temperature Management Following Cardiac Arrest: In-Hospital Trends in Utilization

“…However, for IHCA, hospital response times in initiating cardiopulmonary resuscitation are likely more rapid than from bystanders during OHCA, the advantages of initiatingTTM treatment in the In-Hospital setting to reduce reperfusion injury due to prolonged brain anoxia may differ as compared with the Out-of-Hospital setting. To date, randomized trials of TTM for IHCA in adults do not exist but a recent trial of TTM in children for IHCA found no difference in In-Hospital and 1 year survival between those managed with TTM to 32 to 34 Celsius vs. a control group which focused on avoidance for fever [15]. Additionally, observational studies, though limited, have not found a consistent benefit of TTM for patients with IHCA.…”

Therapeutic hypothermia for children after in-hospital cardiac arrest not helpful

“…This generated a list of clinical trials and review articles, including a recent multicenter randomized control trial addressing the topic of therapeutic hypothermia for in-hospital cardiac arrest in pediatric patients. 1 Using the bibliography for this trial, two retrospective studies addressing the same topic were identified. 2 Additionally, a multicenter randomized control trial addressing out-of-hospital cardiac arrest in pediatric patients was identified.…”