Therapeutic exploration of polyherbal formulation against letrozole induced PCOS rats: A mechanistic approach

Balasubramanian, A.; Pachiappan, Sudhakar; Mohan, Surendiran; Harikrishnan, Adhikesavan; Karuppasamy, Indira; Ramalingam, Kothai

doi:10.1016/j.heliyon.2023.e15488

Cited by 10 publications

(1 citation statement)

References 56 publications

(65 reference statements)

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“…In PCOS-induced albino female Wistar rats, which are animal models, there was a decrease in testosterone volume and an increase in the efflux of female hormone ingredients, which promoted ovarian development and helped to manage menses. The seed extract of C. bonducella produced significantly lower levels of testosterone while also exhibiting superior antiandrogenic effects 30,31 .…”

Section: Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

Exploring the Therapeutic Potential of <i>Caesalpinia bonducella</i> for Male and Female Reproductive Health: A Comprehensive Review

Muthuswamy,

Ragunathan,

Dharmalingam

et al. 2024

JNR

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This review explores the potential of Caesalpinia bonducella Linn., particularly its seeds, known as ‘bounducella’ or ‘little ball’, and its impact on diverse pharmacological activities. Its use in treating various illnesses, including male and female reproductive health, has been investigated. The data, gathered from reliable sources worldwide, transcend language barriers and align with Indian Ayurvedic and Siddha Pharmacopoeias. This article has compiled the pharmacognostic and phytochemical profiles of the seeds, emphasizing their influence on reproductive health, potentially aiding in PCOS management and addressing hyperandrogenism. Additionally, the seed extract of this plant has abortifacient and anti-fertility effects, suggesting that it is a potential alternative to Mifepristone. Nevertheless, further in vivo and in vitro research on seed constituents is essential for developing lead molecules for use in allopathic treatment.

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Section: Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

Exploring the Therapeutic Potential of <i>Caesalpinia bonducella</i> for Male and Female Reproductive Health: A Comprehensive Review

Muthuswamy,

Ragunathan,

Dharmalingam

et al. 2024

JNR

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Fisetin ameliorates polycystic ovary syndrome in rats via a mechanistic modulation of AMP-activated protein kinase and SIRT1 molecular pathway

Chahal,

Kabra

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Diacerein and myo-inositol alleviate letrozole-induced PCOS via modulation of HMGB1, SIRT1, and NF-kB: A comparative study

Khodir,

Sweed,

Motawea

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Polycystic ovary syndrome (PCOS) is the most prevalent cause of anovulatory infertility in women. Myo-inositol supplementation has displayed effectiveness in curing PCOS patients. Diacerein, an anti-inflammatory medication, has not been extensively studied in the context of reproductive disorders. This study aimed to compare the role of myo-inositol and diacerein in PCOS and the probable mechanisms mediating their actions. Forty adult female rats were divided equally into the following: control, PCOS, PCOS+Myo-inositol, and PCOS+Diacerein groups. Rats were subjected to arterial blood pressure (ABP), electromyography (EMG), and uterine reactivity measurements. Blood samples were collected for measuring hormonal assays, glycemic state, lipid profile, oxidative stress, and inflammatory markers. Ovaries and uteri were extracted for histological examination, including hematoxylin and eosin staining, Masson’s trichrome staining, immunohistochemistry, and rt-PCR analysis of ovarian tissues. PCOS was associated with significant increases in ABP, uterine frequency and amplitude of contraction, luteinizing hormone, testosterone, lipid, glycemic and inflammatory markers, malondialdehyde, high-mobility group box 1 (HMGB1), nuclear factor kappa (NF-kB), ovarian fibrosis, and endometrial thickening. In contrast, there was a significant reduction in follicular stimulating hormone, reduced glutathione, and Sirtuin 1 (SIRT1) when compared with control group. Both myo-inositol and diacerein counteract PCOS changes; but diacerein’s effects were superior to myo-inositol’s for all parameters, except for lipid and glycemic markers. Diacerein possessed anti-inflammatory properties and showed significant efficacy in mitigating the endocrinal, metabolic, and ovarian structural alterations linked to PCOS. Its beneficial actions likely stem from reducing oxidative stress, dyslipidemia, and hyperglycemia, potentially through the modulation of HMGB1, SIRT1, and NF-kB pathways.

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Therapeutic exploration of polyherbal formulation against letrozole induced PCOS rats: A mechanistic approach

Cited by 10 publications

References 56 publications

Exploring the Therapeutic Potential of <i>Caesalpinia bonducella</i> for Male and Female Reproductive Health: A Comprehensive Review

Exploring the Therapeutic Potential of <i>Caesalpinia bonducella</i> for Male and Female Reproductive Health: A Comprehensive Review

Fisetin ameliorates polycystic ovary syndrome in rats via a mechanistic modulation of AMP-activated protein kinase and SIRT1 molecular pathway

Diacerein and myo-inositol alleviate letrozole-induced PCOS via modulation of HMGB1, SIRT1, and NF-kB: A comparative study

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