Therapeutic evidence of umbilical cord-derived mesenchymal stem cell transplantation for cerebral palsy: a randomized, controlled trial

Gu, Jiaowei; Huang, Li; Che, Zhang; Wang, Yong; Zhang, Ruibo; Tu, Zhiguang; Wang, Hengdong; Zhou, Xihui; Xiao, Zhousheng; Liu, Zegan; Hu, Xiang; Ke, Zunchen; Wang, Da-Bin; Liu, Li

doi:10.1186/s13287-019-1545-x

Cited by 66 publications

(69 citation statements)

References 47 publications

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“…The stem cell therapy used in the three RCTs was hUC-MSCs; the other stem cell used in the RCT was BMSC. The amount of hMSC transplants in RCTs of Huang et al [ 12 ] and Gu et al [ 13 ] and were 5 × 10 7 and (5.00 ± 0.50) × 10 7 . The dosage of hMSC transplants in the other two studies was 1 × 10 6 /kg and 1 × 10 7 .…”

Section: Resultsmentioning

confidence: 99%

“…RCTs of Huang et al and Peng et al [ 15 ] did not report randomized methods and were assessed of “unclear risk” and “high risk” in selection bias. After randomization, the study processes of Liu et al [ 14 ] and Gu et al [ 13 ] were blinded to the patient groups, participant surgeons, coordinators, and the investigators. We evaluated them as “low risk” in selection bias, performance bias, and detection bias.…”

Section: Resultsmentioning

confidence: 99%

“…CFA is mainly used to evaluate function improvement and therapeutic effect of patients with CP. The RCTs of Gu et al [ 13 ] and Huang et al reported the changes of CFA in patients with CP after hMSC therapy. The results of both studies have shown that hMSC therapy could significantly improve CFA in patients with CP.…”

Section: Discussionmentioning

confidence: 99%

“…We included 4 RCTs on hMSC therapy for CP. The RCT of Gu et al [ 13 ] reported the incidence of upper respiratory infection (52.63%), diarrhea (31.58%), fever (36.84%), and constipation (5.26%) in the hMSC group and upper respiratory infection (70.00%), diarrhea (45.00%), fever (15.00%), and constipation (15.00%) in the control group. The RCT of Huang et al [ 12 ] also reported the incidence of upper respiratory infection (33.33%), diarrhea (18.52%), and constipation (7.41%) in the hMSC group and upper respiratory infection (29.62%), diarrhea (18.52%), and constipation (7.41%) in the control group.…”

Section: Discussionmentioning

confidence: 99%

“…The study indicated that UC-MSC transplantation would be effective in improving functions for CP [ 12 ]. Another RCT also found that UC-MSC transplantation significantly improved GMFM and CFA scores without statistical significance in the incidence of AE between the two groups [ 13 ]. Increasing evidences show that hMSC transplantation has a therapeutic potential in the treatment of CP in some clinical studies.…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Evidence of Human Mesenchymal Stem Cell Transplantation for Cerebral Palsy: A Meta-Analysis of Randomized Controlled Trials

Xie

Chen

et al. 2020

Stem Cells International

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Cerebral palsy (CP) is a kind of movement and posture disorder syndrome in early childhood. In recent years, human mesenchymal stem cell (hMSC) transplantation has become a promising therapeutic strategy for CP. However, clinical evidence is still limited and controversial about clinical efficacy of hMSC therapy for CP. Our aim is to evaluate the efficacy and safety of hMSC transplantation for children with CP using a meta-analysis of randomized controlled trials (RCTs). We conducted a systematic literature search including Embase, PubMed, ClinicalTrials.gov, Cochrane Controlled Trials Register databases, Chinese Clinical Trial Registry, and Web of Science from building database to February 2020. We used Cochrane bias risk assessment for the included studies. The result of pooled analysis showed that hMSC therapy significantly increased gross motor function measure (GMFM) scores (standardized mean difference SMD=1.10, 95%CI=0.66‐1.53, P<0.00001, high-quality evidence) and comprehensive function assessment (CFA) (SMD=1.30, 95%CI=0.71‐1.90, P<0.0001, high-quality evidence) in children with CP, compared with the control group. In the subgroup analysis, the results showed that hMSC therapy significantly increased GMFM scores of 3, 6, and 12 months and CFA of 3, 6, and 12 months. Adverse event (AE) of upper respiratory infection, diarrhea, and constipation was not statistically significant between the two groups. This meta-analysis synthesized the primary outcomes and suggested that hMSC therapy is beneficial, effective, and safe in improving GMFM scores and CFA scores in children with CP. In addition, subgroup analysis showed that hMSC therapy has a lasting positive benefit for CP in 3, 6, and 12 months.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Therapeutic Evidence of Human Mesenchymal Stem Cell Transplantation for Cerebral Palsy: A Meta-Analysis of Randomized Controlled Trials

Xie

Chen

et al. 2020

Stem Cells International

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From Phenomenon to Essence: A Newly Involved lncRNA Kcnq1ot1 Protective Mechanism of Bone Marrow Mesenchymal Stromal Cells in Liver Cirrhosis

Zhangdi,

Jiang,

Gao

et al. 2023

Advanced Science

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Bone marrow mesenchymal stromal cells (BMSCs) have a protective effect against liver cirrhosis. Long noncoding RNAs (lncRNAs) play crucial roles in the progression of liver cirrhosis. Therefore, it is aimed to clarify the lncRNA Kcnq1ot1 involved protective mechanism of BMSCs in liver cirrhosis. This study found that BMSCs treatment attenuates CCl4‐induced liver cirrhosis in mice. Additionally, the expression of lncRNA Kcnq1ot1 is upregulated in human and mouse liver cirrhosis tissues, in addition to TGF‐β1‐treated LX2 cells and JS1 cells. The expression of Kcnq1ot1 in liver cirrhosis is reversed with BMSCs treatment. The knockdown of Kcnq1ot1 alleviated liver cirrhosis both in vivo and in vitro. Fluorescence in situ hybridization (FISH) confirms that Kcnq1ot1 is mainly distributed in the cytoplasm of JS1 cells. It is predicted that miR‐374‐3p can directly bind with lncRNA Kcnq1ot1 and Fstl1, which is verified via luciferase activity assay. The inhibition of miR‐374‐3p or the overexpression of Fstl1 can attenuate the effect of Kcnq1ot1 knockdown. In addition, the transcription factor Creb3l1 is upregulated during JS1 cells activation. Moreover, Creb3l1 can directly bind to the Kcnq1ot1 promoter and positively regulate its transcription. In conclusion, BMSCs alleviate liver cirrhosis by modulating the Creb3l1/lncRNA Kcnq1ot1/miR‐374‐3p/Fstl1 signaling pathway.

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Hybrid umbilical cord blood banking: literature review

Laue

Ambühl

Surbek

2023

Arch Gynecol Obstet

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Purpose Interest gaps between public and private umbilical cord blood banks have led to the introduction of hybrid banking options. Hybrid models combine features of private and public banks as well as interests of parents, children and of patients, in order to find an optimized solution. While several different models of hybrid banks exist, there is a lack of literature about this novel model of cord blood stem cell banking. Therefore, the aim of this literature review is to assess different options of umbilical cord blood banking and whether hybrid banking could be a valuable alternative to the existing public and private cord blood banking models. Methods We performed a systematic literature search, using five main databases. Five hybrid models regarding their advantages as well as their challenges are discussed in this review. Results We found that a wealth of literature exists about public cord blood banking, while private and hybrid banking are understudied. Different modalities of hybrid cord blood banking are being described in several publications, providing the basis to assess different advantages and disadvantages as well as practicability. Conclusion Hybrid banks, especially the sequential model, seem to have potential as an alternative to the existing banking models worldwide. A previously conducted survey among pregnant women showed a preference for hybrid banking, if such an option was available. Nevertheless, opinions among stakeholders differ and more research is needed to evaluate, if hybrid banking provides the expected benefits.

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Therapeutic evidence of umbilical cord-derived mesenchymal stem cell transplantation for cerebral palsy: a randomized, controlled trial

Cited by 66 publications

References 47 publications

Therapeutic Evidence of Human Mesenchymal Stem Cell Transplantation for Cerebral Palsy: A Meta-Analysis of Randomized Controlled Trials

Therapeutic Evidence of Human Mesenchymal Stem Cell Transplantation for Cerebral Palsy: A Meta-Analysis of Randomized Controlled Trials

From Phenomenon to Essence: A Newly Involved lncRNA Kcnq1ot1 Protective Mechanism of Bone Marrow Mesenchymal Stromal Cells in Liver Cirrhosis

Hybrid umbilical cord blood banking: literature review

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