Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish

Rishitha, Narahari; Muthuraman, Arunachalam

doi:10.1016/j.lfs.2018.03.010

Cited by 91 publications

(47 citation statements)

References 48 publications

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“…It also inhibits lipid peroxidation and platelet aggregation, and it stimulates mitochondrial biogenesis [32]. Several studies have reported on the neuroprotective effects of quercetin, both in vitro and in vivo models of neurodegenerative disorders, such as cognitive impairment [33], ischemia, traumatic injury [34], Parkinson's disease (PD) [35], and Huntington's disease (HD) [36]. The aim of the present review is to provide a summary of the recent literature exploring the relationship between quercetin and cognitive performance.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

et al. 2019

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Quercetin is a flavonoid with notable pharmacological effects and promising therapeutic potential. It is widely distributed among plants and found commonly in daily diets predominantly in fruits and vegetables. Neuroprotection by quercetin has been reported in several in vitro studies. It has been shown to protect neurons from oxidative damage while reducing lipid peroxidation. In addition to its antioxidant properties, it inhibits the fibril formation of amyloid-β proteins, counteracting cell lyses and inflammatory cascade pathways. In this review, we provide a synopsis of the recent literature exploring the relationship between quercetin and cognitive performance in Alzheimer’s disease and its potential as a lead compound in clinical applications.

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Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

et al. 2019

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“…Sun D. et al [10] designed PLGA-functionalized quercetin nanoparticles to facilitate the controlled delivery of quercetin into brain. Another two articles also evaluated the therapeutic efficacy of solid lipid nanoparticles of quercetin and quercetin-loaded in zein nanoparticles on experimental AD models [11,14]. In fact, the clinical approach of quercetin utilization is highly hampered by its low oral bioavailability (about 2%), which is due to the low aqueous solubility and partial permeability of blood-brain barrier (BBB).…”

Section: Methodological Quality Assessmentmentioning

confidence: 99%

“…The Aβ injection model can induce Aβ accumulation and deposition in the brain, but as an acute toxicity model it cannot reproduce the progressive neurodegeneration process [18]. The drug-induced models (LPS and PTZ) display neurodegeneration and cognitive impairments, but they lack AD-related histological hallmarks [13,14]. Senescence-accelerated mice belong to a naturally rapidly aging species, and this accelerated aging-induced dementia model can recapture the cognitive impairment and pathological features that are closer to actual AD patients [11].…”

Section: Different Animal Modelsmentioning

confidence: 99%

“…Malondialdehyde (MDA) is produced from lipid peroxidation and generally regarded as a marker of oxidant injury. Rishitha N. et al [14] reported that the solid lipid nanoparticle of quercetin (SLN-Q) had an ameliorative effect on the decreased GSH levels in AD zebrafish brains in a dose-dependent manner. Li Y. et al [18] indicated that in quercetin-treated Meanwhile, three included studies measured Aβ levels in the CA1 regions and cortexes of mice's brains by immunohistochemistry (IHC).…”

Section: Neuroprotective Mechanisms Analysismentioning

confidence: 99%

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Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies

Zhang

Chen

Ouyang

et al. 2020

IJMS

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Alzheimer’s disease (AD) is the leading cause of dementia worldwide. It involves progressive impairment of cognitive function. A growing number of neuroprotective compounds have been identified with potential anti-AD properties through in vitro and in vivo models of AD. Quercetin, a natural flavonoid contained in a wide range of plant species, is repeatedly reported to exert neuroprotective effects in experimental animal AD models. However, a systematic analysis of methodological rigor and the comparison between different studies is still lacking. A systematic review uses a methodical approach to minimize the bias in each independent study, providing a less biased, comprehensive understanding of research findings and an objective judgement of the strength of evidence and the reliability of conclusions. In this review, we identified 14 studies describing the therapeutic efficacy of quercetin on animal AD models by electronic and manual retrieval. Some of the results of the studies included were meta-analyzed by forest plot, and the methodological quality of each preclinical trial was assessed with SYRCLE’s risk of bias tool. Our results demonstrated the consistent neuroprotective effects of quercetin on different AD models, and the pharmacological mechanisms of quercetin on AD models are summarized. This information eliminated the bias of each individual study, providing guidance for future tests and supporting evidence for further implementation of quercetin into clinical trials. However, the limitations of some studies, such as the absence of sample size calculations and low method quality, should also be noted.

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“…Recently, effects of solid lipid nanoparticle of quercetin in pentylenetetrazole (PTZ) induced cognitive impairment of Danio rerio species were evaluated. The administration of quercetin nanoparticles (5 and 10 mg/kg) ameliorate the PTZ exposure induces cognitive impairment, due to its potential anti-oxidative, anti-lipid peroxidative and acetylcholinesterase (AChE) inhibitory actions [95]. Epicatechin and myricetin, could inhibit neuronal death, through antioxidative mechanisms in cultured mouse cortical neurons (Figure 4) [96].…”

Section: Targeting Oxidative Stressmentioning

confidence: 99%

Wine Polyphenols and Neurodegenerative Diseases: An Update on the Molecular Mechanisms Underpinning Their Protective Effects

Silva

Vauzour

2018

Beverages

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Alzheimer's and Parkinson's diseases are the most common age-related and predominantly idiopathic neurodegenerative disorders of unknown pathogenesis. Although these diseases differ in their clinical and neuropathological features, they also share some common aetiologies, such as protein aggregation, mitochondrial dysfunction, oxidative stress, and neuroinflammation. Epidemiological, in vitro and in vivo evidences suggest an inverse correlation between wine consumption and the incidence of neurodegenerative disorders. Wine benefits are, in large part, attributable to the intake of specific polyphenols, which mediate cell function under both normal and pathological conditions. In this review, we aim to provide an overview of the role that wine polyphenols play in delaying neurodegenerative disorders. We discuss animal and in vitro studies in support of these actions and we consider how their biological mechanisms at the cellular level may underpin their physiological effects. Together, these data indicate that polyphenols present in wine may hold neuroprotective potential in delaying the onset of neurodegenerative disorders.

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Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish

Cited by 91 publications

References 48 publications

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

Quercetin in Animal Models of Alzheimer’s Disease: A Systematic Review of Preclinical Studies

Wine Polyphenols and Neurodegenerative Diseases: An Update on the Molecular Mechanisms Underpinning Their Protective Effects

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