Therapeutic efficiency of the APAF‐1 antagonist LPT99 in a rat model of cisplatin‐induced hearing loss

Murillo-Cuesta, Silvia; Celaya, Adelaida M.; Cervantes, Blanca; Bermúdez-Muñoz, Jose Ma; Rosa, Lourdes Rodríguez-de la; Contreras, Julio; Sánchez‐Pérez, Isabel; Varela‐Nieto, Isabel

doi:10.1002/ctm2.363

Cited by 7 publications

(2 citation statements)

References 11 publications

(8 reference statements)

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“…SNHL is intensified due to the exposure to pollutants such as carbon monoxide (CO) ( Marcano Acuña et al, 2019 ), hydrogen cyanide ( Fechter et al, 2002 ), trimethyltin ( Yu et al, 2016 ) and acrylonitrile, as well as by the combination of high levels of noise and these toxins ( Fechter et al, 2004 ; Pouyatos et al, 2009 ). SNHL is also caused by drugs such as aminoglycosides and cisplatin ( Kros and Steyger, 2019 ; Murillo-Cuesta et al, 2021 ). Although the underlying mechanisms of age- or environmental toxins- mediated SNHL are still unknown, there is large consensus in that free radical processes are effectively involved ( Fechter et al, 2004 ; Wang et al, 2007 ; Fetoni et al, 2019 ; Varela-Nieto et al, 2020 ).…”

Section: Nitrones As Therapeutic Agents For Sensorineural Hearing Lossmentioning

confidence: 99%

Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges

Varela‐Nieto

Murillo-Cuesta²,

Rosa³

et al. 2021

Front. Cell. Neurosci.

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Nitrones are potent antioxidant molecules able to reduce oxidative stress by trapping reactive oxygen and nitrogen species. The antioxidant potential of nitrones has been extensively tested in multiple models of human diseases. Sensorineural hearing loss has a heterogeneous etiology, genetic alterations, aging, toxins or exposure to noise can cause damage to hair cells at the organ of Corti, the hearing receptor. Noxious stimuli share a battery of common mechanisms by which they cause hair cell injury, including oxidative stress, the generation of free radicals and redox imbalance. Therefore, targeting oxidative stress-mediated hearing loss has been the subject of much attention. Here we review the chemistry of nitrones, the existing literature on their use as antioxidants and the general state of the art of antioxidant treatments for hearing loss.

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Section: Nitrones As Therapeutic Agents For Sensorineural Hearing Lossmentioning

confidence: 99%

Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges

Varela‐Nieto

Murillo-Cuesta²,

Rosa³

et al. 2021

Front. Cell. Neurosci.

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“…[1][2][3][4] Heredity. [5][6] age factors, [7][8] autoimmune disorders, [9][10] pathogen (viral, bacterial, and fungal), [11][12][13][14][15] environmental factors (exposure to excessive noise and radiation), [16][17] increase in life expectancy, chemotherapeutic drugs induced ototoxic [18][19] are the main cause for the most of the disorders in the otic region. Despite ear disorders have not been considered as life-threatening issue, sometimes they lead to some form of mild to irreversible hearing impairment.…”

Section: Introductionmentioning

confidence: 99%

An Overview of Nanoparticle Drug Delivery for Ototoxin and Noise Mediated Hearing Loss Treatment

Sreeharsha¹,

Nataraj²,

Jang³

et al. 2022

Ind. J. Pharm. Edu. Res

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Efficient delivery of therapeutic material to target site of the inner ear is considered as the most challenging process due to their poor blood flow and inaccessibility sensitivity towards chemical stimuli, inability of drug to be delivered as well. Novel nanoparticlebased drug transport approaches have emerged for overcoming the restriction associated with inner ear therapeutic material delivery. The main focus of this article is to highlight the potential benefits, pre-clinical level otoprotective effect of different types of NPs based payload delivery strategies in mitigating sensorineural hearing impairment resulting from medication (cisplatin and antibiotic treatment) and noise exposure. This review converses about advantage of nanocarrier assisted targeted cell specific inner ear drug delivery approach and demonstrates that targeted NPs delivery systems have the capability to be utilized as vehicle to transport therapeutic materials into the OHCs within the cochlea in controlled and sustained way and maximize following therapeutic effects. Efficacy of systemic and minimally invasive intratympanic and RWM approach for delivering steroids/ genetic material to the inner ear has also been compared in this article. Understanding the importance (design, formulation, cochlear biocompatibility and cell specific binding efficiency of NPs, mechanistic pathways, route of delivery, positive therapeutic outcomes) and hitches (adverse effects after treatment, negative therapeutic outcome) of currently available NPs based drug delivery systems offer new opportunity to develop best treatment methods for sensorineural hearing dysfunction.

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Hearing loss drug discovery and medicinal chemistry: Current status, challenges, and opportunities

Cousins

2022

Progress in Medicinal Chemistry

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Therapeutic efficiency of the APAF‐1 antagonist LPT99 in a rat model of cisplatin‐induced hearing loss

Cited by 7 publications

References 11 publications

Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges

Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges

An Overview of Nanoparticle Drug Delivery for Ototoxin and Noise Mediated Hearing Loss Treatment

Hearing loss drug discovery and medicinal chemistry: Current status, challenges, and opportunities

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