Therapeutic efficacy of the root tubers of Aconitum heterophyllum and its substitute Cyperus rotundus in the amelioration of pylorus ligation induced ulcerogenic and oxidative damage in rats

Rajakrishnan, R.; Alfarhan, Ahmed; Al-Ansari, Abdullah; Lekshmi, R.; Sreelakshmi, R.; Benil, P.B.; Kim, Y.-O.; Tack, J.-C.; Na, S.W.; Kim, H.-J.

doi:10.1016/j.sjbs.2019.12.025

Cited by 13 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…C. rotundus (Xiangfu in Chinese, XF) has been widely used in TCM for the treatment of stomach ailments, wounds, boils, and blisters. A number of pharmacological and biological activities including anti‐inflammatory, antidiabetic, antidiarrheal, cytoprotective, antimutagenic, antibacterial, antioxidant, anti‐pyretic, and analgesic activities have been reported for this plant [8,9] . In TCM theory and practice, herbal pairs (HPs) are unique combinations of two herbs at a standard ratio that is determined from years of practice.…”

Section: Introductionmentioning

confidence: 99%

“…A number of pharmacological and biological activities including anti-inflammatory, antidiabetic, antidiarrheal, cytoprotective, antimutagenic, antibacterial, antioxidant, antipyretic, and analgesic activities have been reported for this plant. [8,9] In TCM theory and practice, herbal pairs (HPs) are unique combinations of two herbs at a standard ratio that is determined from years of practice. It has been reported that many well-established HPs demonstrated better efficacy and/or lower toxicity than single herbs, although the exact mechanisms have not yet been discovered.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chemical Constituents and Anti‐Gastric Ulcer Activity of Essential Oils of Alpinia officinarum (Zingiberaceae), Cyperus rotundus (Cyperaceae), and Their Herbal Pair

et al. 2021

Chemistry & Biodiversity

View full text Add to dashboard Cite

The essential oil (EO) of the herbal pair (HP), Alpinia officinarum‐Cyperus rotundus (HP G‐X) has been conventionally used in traditional Chinese medicine (TCM) for ‘warming the stomach’ and relieving pain. However, its pharmacologically active compounds, as well as the mechanism of its anti‐gastric ulcer properties remain unclear. In this study, the EOs obtained from HP G‐X and its corresponding single herbs were analyzed using GC/MS. A total of 74, 56, and 85 compounds were detected in A. officinarum (GLJ), C. rotundus (XF), and HP G‐X, accounting for 93.2 %, 89.5 %, and 92.0 % of the total content, respectively. GLJ mainly contains 1,8‐cineol (22.0 %) and α‐terpineol (11.8 %), whereas cyperenone (22.4 %) and cyperene (12.3 %) were the major constituents in XF. These four compounds were also detected in the HP G‐X with relatively high composition as 11.8 %, 5.5 %, 11.8 %, and 10.6 %, respectively. Although no new compounds were detected in HP G‐X, the relative concentration of some compounds increased, while others decreased or even disappeared. HP G‐X showed the lowest toxicity (TC50 >800 μg/mL) against human gastric mucosal epithelial cells (GES‐1) and had the best protective effect against ethanol‐induced GES‐1 cell damage compared to the individual herbs. In vitro studies demonstrated that HP G‐X and the corresponding single herbs significantly reduced IL‐6, TNF‐α, and COX‐2. In addition, in vivo investigations indicated that HP G‐X can protect the gastric mucosa of mice from ethanol‐induced damage by inhibiting the inflammatory reaction and providing analgesia. It can also inhibit the expression of NF‐κBp65, COX‐2, and TRPV1 protein, reduce the concentrations of IL‐6 and TNF‐α, and relieve heat‐induced pain. This study further substantiated the traditional application of HP G‐X against gastric ulcers through both in vivo and in vitro investigations.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical Constituents and Anti‐Gastric Ulcer Activity of Essential Oils of Alpinia officinarum (Zingiberaceae), Cyperus rotundus (Cyperaceae), and Their Herbal Pair

et al. 2021

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…Cyperus rotundus exhibited gastroprotective potential when tested in Wistar albino rats via the pylorus ligation-induced ulcer model [ 63 ]. Also, C. rotundus exhibited an antiulcer property when used at a dose of 500 mg/kg against the aspirin-induced ulcer model [ 62 ].…”

Section: Resultsmentioning

confidence: 99%

Medicinal Plants with Prospective Benefits in the Management of Peptic Ulcer Diseases in Ghana

Boakye-Yiadom

Kumadoh

Adase

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

Background. The growth or multiplication of harmful microorganisms in addition to harmful human activities has led to many disorders in humans. Consequently, there is a search for medications to treat these disorders. Interestingly, medicines of plant origin are known to be among the most attractive sources of new drugs and have shown promising results in the treatment of various diseases including peptic ulcers. This review, therefore, is aimed at obtaining knowledge on some Ghanaian ethnomedicinal plants used to treat peptic ulcers, their folkloric uses, their phytochemicals, and their antiulcer and related pharmacological activities as well as finding areas for prospective studies.Methods. Published peer-reviewed articles on ethnomedicinal plants used for the management of peptic ulcers in Ghana from 1967 to 2020 were sourced and used for the study. Results. In this review, 13 plants were identified which belong to 10 different families including Sapindaceae, Apocynaceae, and Bignoniaceae. The parts most often used for most preparations were the leaves (53%), followed by stem bark and roots (both having the same percentage of use of 17.6%), the whole plant (5.9%), and the rhizomes (5.9%). Azadirachta indica was the only plant that had undergone some patient studies in addition to animal studies. Conclusion. A discussion of various antiulcer activity studies using ulcer models carried out on selected medicinal plants used for the management of peptic ulcer disease in addition to brief information on their folkloric uses and their phytochemical and other pharmacological properties is presented. These medicinal plants may be used in developing herbal products for the management of peptic ulcer disease.

show abstract

“…As well, gastric distension produced by the accumulation of secretion seems to influence the gastric acid secretion of this model, possibly by increasing the release of gastrin hormone, a potent stimulator of parietal cells to produce hydrochloric acid. Pyloric ligation leads to the accumulation of gastric acid and pepsin, favouring self-digestion of the gastric mucosa and ulceration ( Rajakrishnan et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

(-)-Carveol Prevents Gastric Ulcers via Cytoprotective, Antioxidant, Antisecretory and Immunoregulatory Mechanisms in Animal Models

et al. 2021

View full text Add to dashboard Cite

Background: (-)-Carveol (p-Mentha-6,8-dien-2-ol) is a monocyclic monoterpenic alcohol, present in essential oils of plant species such as Cymbopogon giganteus, Illicium pachyphyllum and in spices such as Carum carvi (cumin). Pharmacological studies report its antitumor, antimicrobial, neuroprotective, vasorelaxant, antioxidant and anti-inflammatory activity.Hypothesis/Purpose: The objective of this study was to evaluate the acute non-clinical oral toxicity, gastroprotective activity of monoterpene (-)-Carveol in animal models and the related mechanisms of action.Methods: Acute toxicity was assessed according to OECD guide 423 in mice. Ethanol, stress, NSAIDs and pylorus ligation-induced gastric ulcer models were used to investigate antiulcer properties. The related mechanisms of action were using the ethanol-gastric lesions protocol.Results: (-)-Carveol has low toxicity, with a lethal dose 50% (LD50) equal to or greater than 2,500 mg/kg according to OECD guide nº 423. In all gastric ulcer induction methods evaluated, (-)-Carveol (25, 50, 100 and 200 mg/kg, p.o.) significantly reduced the ulcerative lesion in comparison with the respective control groups. To investigate the mechanisms involved in the gastroprotective activity, the antisecretory or neutralizing of gastric secretion, cytoprotective, antioxidant and immunoregulatory effects were evaluated. In the experimental protocol of pylorus ligation-induced gastric ulcer, (-)-Carveol (100 mg/kg) reduced (p < 0.001) the volume of gastric secretion in both routes (oral and intraduodenal). The previous administration of blockers NEM (sulfhydryl groups blocker), L-NAME (nitric oxide synthesis inhibitor), glibenclamide (KATP channel blocker) and indomethacin (cyclo-oxygenase inhibitor), significantly reduced the gastroprotection exercised by (-)-Carveol, suggesting the participation of these pathways in its gastroprotective activity. In addition, treatment with (-)-Carveol (100 mg/kg) increased (p < 0.001) mucus adhered to the gastric wall. Treatment also increased (p < 0.001) levels of reduced glutathione (GSH), superoxide dismutase (SOD) and interleukin-10 (IL-10). It also reduced (p < 0.001) malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels.Conclusion: Thus, it is possible to infer that (-)-Carveol presents gastroprotective activity related to antisecretory, cytoprotective, antioxidant and immunomodulatory mechanisms.

show abstract

Therapeutic efficacy of the root tubers of Aconitum heterophyllum and its substitute Cyperus rotundus in the amelioration of pylorus ligation induced ulcerogenic and oxidative damage in rats

Cited by 13 publications

References 23 publications

Chemical Constituents and Anti‐Gastric Ulcer Activity of Essential Oils of Alpinia officinarum (Zingiberaceae), Cyperus rotundus (Cyperaceae), and Their Herbal Pair

Chemical Constituents and Anti‐Gastric Ulcer Activity of Essential Oils of Alpinia officinarum (Zingiberaceae), Cyperus rotundus (Cyperaceae), and Their Herbal Pair

Medicinal Plants with Prospective Benefits in the Management of Peptic Ulcer Diseases in Ghana

(-)-Carveol Prevents Gastric Ulcers via Cytoprotective, Antioxidant, Antisecretory and Immunoregulatory Mechanisms in Animal Models

Contact Info

Product

Resources

About