Therapeutic Efficacy of the Drug “Submastin-Сattle” for Therapy of Subclinical Mastitis in Cows

Gritsyuk, V.A.; Востроилова, Г. А.; Klimov, N. T.; Хохлова, Н. А.; Zimnikov, V. I.; Korchagina, A.A.

doi:10.52368/2078-0109-58-1-8-11

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“…Цитокины -белковое соединение, являющееся совокупностью интерлейкинов и интерферонов. Их функция заключается в нарушении биоэнергетических запасов микроорганизмов и усилении эффективности макрофагов [2,9]. В связи с этим нами была поставлена цель -провести анализ эффективности применения комплексной мази «Уберосепт» в сочетании с различными иммуномодуляторами в производственных условиях.…”

Section: Introductionunclassified

Morphobiochemical status of cows’ blood during therapy of subclinical mastitis with the complex ointment "Uberosept" together with immunomodulators

Peregonchiy,

Pavlenko,

Zimnikov

2024

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The studies were conducted on lactating cows of Red-Motley Holstein and Simmental breeds with subclinical mastitis aged from 1 to 8 lactations. Four groups of animals of 10 animals each were selected. The first group was treated with the complex ointment “Uberosept” once a day, externally for 5 days. The second group received “Uberosept” 1 time per day, externally for 5 days, “Mixoferon” 3 ml intramuscularly 2 times a day for 7 days. The third group received “Uberosept” 1 time per day, externally for 5 days, “Submastin-KRS” 10 ml intramuscularly 1 time per day for 3 days. Blood samples were taken from all experimental groups to study morphobiochemical indicators and indicators of lipid peroxidation, antioxidant protection and endogenous intoxication. The samples were taken before treatment, immediately after the course of treatment and 7 days after treatment. The highest therapeutic effectiveness of the treatment regimen for subclinical mastitis used in the second experimental group was 90.0%. In the first experimental group, the therapeutic effectiveness was 60.0%, in the second experimental group - 80.0%. This was confirmed by morphobiochemical studies; in the group of animals that were injected with “Mixoferon” + complex ointment “Uberosept”, immunity indicators were higher than in the group of cows that were treated with “Submastin-KRS” + complex ointment “Uberosept”. At the same time, in the animals of the third experimental group, a more pronounced decrease in the processes of endogenous intoxication, lipid peroxidation and activation of antioxidant protection was observed.

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Section: Introductionunclassified