Therapeutic Efficacy Of Extended Release Oxybutynin Chloride, And Immediate Release And Long Acting Tolterodine Tartrate In Children With Diurnal Urinary Incontinence

Reinberg, Yuri; Crocker, John F. S.; Wolpert, James J.; Vandersteen, David R.

doi:10.1016/s0022-5347(05)64115-8

Cited by 62 publications

(24 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our patients received short-acting anticholinergic medications when indicated. The favorable role of newer anticholinergic preparations for wetting secondary to detrusor instability has recently been reported [10]. In trials comparing the long-and short-acting forms of oxybutynin and tolterodine, long-acting preparations were more efficacious, particularly long-acting oxybutynin.…”

Section: Discussionmentioning

confidence: 97%

Natural history of voiding dysfunction

Saedi

Schulman

2003

Pediatric Nephrology

View full text Add to dashboard Cite

Voiding dysfunction leads to daytime wetting, night-time wetting, and recurrent urinary tract infection (UTI). Our interdisciplinary center has been committed to treating children with dysfunctional voiding since 1992. We describe the long-term follow-up of a large cohort of children using our approach to treatment. We reviewed the records of 199 children with symptoms of voiding dysfunction seen between March 1992 and December 1993. We contacted 98 parents and 51 patients by phone at least 6.5 years after initial presentation and asked about current symptoms, effective strategies, and satisfaction of care. Of the initial group of contacted parents, 81 (83%) were female with a median age of 7.8 years. Patients were followed in the clinic for a mean time of 1.6 years and a median of three visits. Of the 90 patients with daytime wetting, 82 (91%) reported complete resolution with a median time of resolution of 2.9 years. Parents felt that maturation was the most important factor leading to improvement. Of the patients that were directly contacted (41 females, 10 males, median age 15.2 years), all were dry and 86% denied any sense of urgency; 86% of parents and 87% of patients were highly satisfied with their care. Almost every child improved within 5 years of the initial evaluation. Only small fractions are still wet, are infected, or have urgency. Maturation seems to be the most important factor leading to improvement. Most parents and patients are satisfied with this form of treatment.

show abstract

Section: Discussionmentioning

confidence: 97%

Natural history of voiding dysfunction

Saedi

Schulman

2003

Pediatric Nephrology

View full text Add to dashboard Cite

show abstract

“…A recent clinical trial showed superior efficacy of antimuscarinic medication (propiverine) over placebo with a significant reduction of incontinence episodes and voiding frequency, and increase of bladder functional capacity among 171 randomized children with non-neurogenic OAB [14]. Extended release formulations of anticholinergic agents (oxybutynin, tolterodine), although not licensed in children and not available in every country, seem to be used in children with increasing success [15,16].…”

Section: Incontinence During Bladder Filling Overactive Bladdermentioning

confidence: 99%

“…There are however very limited available data on its use in children. Extended release formulations of anticholinergics (oxybutynin chloride, tolterodine tartrate) have also been studied in children with good tolerability and efficacy [15,16]. Trospium chloride (TCl) is an antiparasympathetic quaternary ammonium derivative that has been extensively used and studied in adults with bladder hyperreflexia or instability.…”

Section: Pharmacotherapymentioning

confidence: 99%

Non-neurogenic elimination disorders in children

Leclair

Héloury

2010

Journal of Pediatric Urology

View full text Add to dashboard Cite

“…Zukünftige Entwicklungen beziehen sich auf die Einführung von unterschiedlichen Retardformulierungen die durch Veränderung der pharmakokinetischen Eigenschaften eine bessere Verträglich-keit und erhöhte Wirksamkeit erwarten lassen [13].…”

Section: Medikamentöse Therapieunclassified

Die �beraktive Blase im Kindesalter

Geeter

2004

Urologe [A]

View full text Add to dashboard Cite

According to recent terminology, the symptom complex of frequency and urgency with or without urge incontinence in childhood is called overactive bladder. The main etiologic factor seems to be a delayed maturation of complex neuroanatomic structures responsible for normal bladder control. Afflicted children show a typical pattern of reflex voiding with different degrees of severity. In many cases nocturnal incontinence is the main complaint and this may lead to the wrong diagnosis of nocturnal enuresis with resulting false treatment. The diagnostic work-up consists of standardized evaluation of children with enuresis and voiding dysfunction and should concentrate on the exclusion of any possible underlying neurological disorder. Treatment focuses primarily on behavioral modification and cognitive education with regard to bladder sensation and voluntary micturition. Muscarinic receptor antagonists are very useful as supportive medical treatment with a rather low rate of adverse effects. Children who fail to respond to treatment or children suffering from side effects can profit from alternative treatment modalities including biofeedback programs, pelvic floor stimulation, or acupuncture.

show abstract

Therapeutic Efficacy Of Extended Release Oxybutynin Chloride, And Immediate Release And Long Acting Tolterodine Tartrate In Children With Diurnal Urinary Incontinence

Cited by 62 publications

References 12 publications

Natural history of voiding dysfunction

Natural history of voiding dysfunction

Non-neurogenic elimination disorders in children

Die �beraktive Blase im Kindesalter

Contact Info

Product

Resources

About