Therapeutic efficacy of chloroquine for uncomplicated Plasmodium vivax malaria in southeastern and western border areas of Myanmar

Soe, Myat Thu; Aung, Pyae Linn; Nyunt, Myat Htut; Sein, Myint Myint; Cho, Cho; Yang, Zhaoqing; Menezes, Lynette; Parker, Daniel M.; Kyaw, Myat Phone

doi:10.1007/s15010-021-01739-x

Cited by 1 publication

(1 citation statement)

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“…Thus, we have been conducting longitudinal CQ efficacy studies in sentinel sites at the East and West borders of Myanmar. [55][56][57] These studies have documented deterioration of the clinical efficacy of CQ in several Eastern areas of Myanmar. The most recent study in Northeastern Myanmar showed cases, where CQ failed to clear P. vivax parasitemia within 7 days, suggesting high-grade resistance.…”

Section: Effective Drugs To Eliminate Vivax Malariamentioning

confidence: 99%

Malaria Research for Tailored Control and Elimination Strategies in the Greater Mekong Subregion

Sattabongkot

Bantuchai²,

Chotirat

et al. 2022

The American Journal of Tropical Medicine and Hygiene

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ABSTRACT. The malaria landscape in the Greater Mekong Subregion has experienced drastic changes with the ramp-up of the control efforts, revealing formidable challenges that slowed down the progress toward malaria elimination. Problems such as border malaria and cross-border malaria introduction, multidrug resistance in Plasmodium falciparum, the persistence of Plasmodium vivax, the asymptomatic parasite reservoirs, and insecticide resistance in primary vectors require integrated strategies tailored for individual nations in the region. In recognition of these challenges and the need for research, the Southeast Asian International Center of Excellence for Malaria Research has established a network of researchers and stakeholders and conducted basic and translational research to identify existing and emerging problems and develop new countermeasures. The installation of a comprehensive disease and vector surveillance system at sentinel sites in border areas with the implementation of passive/active case detection and cross-sectional surveys allowed timely detection and management of malaria cases, provided updated knowledge for effective vector control measures, and facilitated the efficacy studies of antimalarials. Incorporating sensitive molecular diagnosis to expose the significance of asymptomatic parasite reservoirs for sustaining transmission helped establish the necessary evidence to guide targeted control to eliminate residual transmission. In addition, this program has developed point-of-care diagnostics to monitor the quality of artemisinin combination therapies, delivering the needed information to the drug regulatory authorities to take measures against falsified and substandard antimalarials. To accelerate malaria elimination, this program has actively engaged with stakeholders of all levels, fostered vertical and horizontal collaborations, and enabled the effective dissemination of research findings.

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Section: Effective Drugs To Eliminate Vivax Malariamentioning

confidence: 99%