2003
DOI: 10.1016/s0264-410x(02)00244-x
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Therapeutic efficacy of an E. coli strain carrying an ovalbumin allergenic peptide as a fused protein to OMPC in a murine model of allergic airway inflammation

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Cited by 7 publications
(4 citation statements)
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“…2c, lanes 2 and 4). This result is consistent with a similar fusion protein in which a foreign sequence was inserted in the fifth loop of OmpC, 42 and may be explained by low efficiency in codon usage, but this issue needs to be further analysed. However, the Western blot using a cocktail of monoclonal antibodies against OmpC was consistent with the electrophoretic pattern (Fig.…”
Section: Resultssupporting
confidence: 86%
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“…2c, lanes 2 and 4). This result is consistent with a similar fusion protein in which a foreign sequence was inserted in the fifth loop of OmpC, 42 and may be explained by low efficiency in codon usage, but this issue needs to be further analysed. However, the Western blot using a cocktail of monoclonal antibodies against OmpC was consistent with the electrophoretic pattern (Fig.…”
Section: Resultssupporting
confidence: 86%
“…These permissive sites are located in the external loops, and that porins in solution have the property to aggregate as trimers. OmpC and other porins have been used for the expression of foreign ‘passenger’ antigens and we have reported that an allergenic peptide fused to the external loop five of OmpC is able to modulate the lung inflammatory response in a mouse model of allergy to ovalbumin 42 …”
Section: Discussionmentioning
confidence: 99%
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“…Previous studies have shown that the insertions into these long loops did not affect the trimerization or the insertion of these porins into the cell membrane . An allergenic peptide of 16 amino acids from ovalbumin and a rotavirus epitope comprising 18 amino acids have been successfully displayed on the loops of S. typhi OmpC . Short epitopes inserted into the long surface accessible loops induce epitope‐specific immune responses and are thus appealing candidates for live recombinant vaccines.…”
Section: Discussionmentioning
confidence: 99%