Therapeutic Efficacy and Migration of Mesenchymal Stem Cells after Intracerebral Transplantation in Rats with Experimental Ischemic Stroke

Namestnikova, D. D.; Gubskiy, I. L.; Cherkashova, Elvira; Sukhinich, K. K.; Melnikov, P. A.; Габашвили, А. Н.; Kurilo, V. V.; Чехонин, В. П.; Gubsky, L. V.; Yarygin, K. N.

doi:10.1007/s10517-023-05822-1

Cited by 3 publications

(1 citation statement)

References 56 publications

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“…While stem cell transplant treatments have been shown to be effective in nerve regeneration from ischemic stroke, they still have the problem of heterogeneity in the body, and stem cells grow slowly in the body, inevitably replicating aging. 117 EVs has low immunogenicity and the ability to cross the blood-brain barrier. It can bind to corresponding targets through various pathways, and the therapeutic effect is no less than that of stem cell transplantation.…”

Section: Discussionmentioning

confidence: 99%

A Promising Application of Injectable Hydrogels in Nerve Repair and Regeneration for Ischemic Stroke

Gao,

Zhang,

Zhang

et al. 2024

IJN

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Ischemic stroke, a condition that often leads to severe nerve damage, induces complex pathological and physiological changes in nerve tissue. The mature central nervous system (CNS) lacks intrinsic regenerative capacity, resulting in a poor prognosis and long-term neurological impairments. There is no available therapy that can fully restore CNS functionality. However, the utilization of injectable hydrogels has emerged as a promising strategy for nerve repair and regeneration. Injectable hydrogels possess exceptional properties, such as biocompatibility, tunable mechanical properties, and the ability to provide a supportive environment for cell growth and tissue regeneration. Recently, various hydrogel-based tissue engineering approaches, including cell encapsulation, controlled release of therapeutic factors, and incorporation of bioactive molecules, have demonstrated great potential in the treatment of CNS injuries caused by ischemic stroke. This article aims to provide a comprehensive review of the application and development of injectable hydrogels for the treatment of ischemic stroke-induced CNS injuries, shedding light on their therapeutic prospects, challenges, recent advancements, and future directions. Additionally, it will discuss the underlying mechanisms involved in hydrogel-mediated nerve repair and regeneration, as well as the need for further preclinical and clinical studies to validate their efficacy and safety.

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Section: Discussionmentioning

confidence: 99%

A Promising Application of Injectable Hydrogels in Nerve Repair and Regeneration for Ischemic Stroke

Gao,

Zhang,

Zhang

et al. 2024

IJN

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Estimation of the Ischemic Lesion in the Experimental Stroke Studies Using Magnetic Resonance Imaging (Review)

Namestnikova,

Cherkashova,

Gumin

et al. 2024

Bull Exp Biol Med

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Mesenchymal stem cells in the treatment of ischemic stroke

Namestnikova,

Kovalenko,

Pokusaeva

et al. 2024

Journal of Clinical Practice

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Over the past three decades, multiple preclinical studies have been conducted and have shown that transplantation of the mesenchymal stem has a pronounced positive effect in animals with experimental stroke. On the base of the promising results of the preclinical studies several clinical trials with the mesenchymal stem cell transplantation in stroke patients have also been conducted. In this review we presented and analyzed the results of completed clinical trials dedicated to the mesenchymal stem cells transplantation in patients with ischemic stroke. According to obtained results it can be concluded that transplantation of the mesenchymal stem cells is safe and feasible from an economic and medical-biological point of view. For further implementation of this promising approach into the clinical practice randomized, placebo-controlled, multicenter clinical trials on a large sample of patients and with the optimize cell transplantation protocols and patients’ inclusion criteria are needed. In this review we also discuss possible strategies to enhance the effectiveness of cell therapy with the use of the mesenchymal stem cells.

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Therapeutic Efficacy and Migration of Mesenchymal Stem Cells after Intracerebral Transplantation in Rats with Experimental Ischemic Stroke

Cited by 3 publications

References 56 publications

A Promising Application of Injectable Hydrogels in Nerve Repair and Regeneration for Ischemic Stroke

A Promising Application of Injectable Hydrogels in Nerve Repair and Regeneration for Ischemic Stroke

Estimation of the Ischemic Lesion in the Experimental Stroke Studies Using Magnetic Resonance Imaging (Review)

Mesenchymal stem cells in the treatment of ischemic stroke

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