Therapeutic effects of α-iso-cubebenol, a natural compound isolated from the Schisandra chinensis fruit, against sepsis

Lee, Sung Kyun; Kim, Sang Doo; Kook, Minsoo; Lee, Ha Young; Park, Joon Seong; Park, Young Hoon; Kang, Jum-Soon; Jung, Woo-Sung; Choi, Young Whan; Bae, Yoe‐Sik

doi:10.1016/j.bbrc.2012.09.094

Cited by 12 publications

(8 citation statements)

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“…In such situations, the bacterial LPS is considered as the causative factor for inducing the immune response, and this may play a predominant role particularly in sepsis‐like conditions [69]. It has been observed that pathogenic conditions aggravate the release of proinflammatory cytokines (TNF‐α and IL‐6, IL‐12) triggering a ‘cytokine storm'‐like effect [70]. In the present investigation, preincubation with MEKB reduced the LPS‐mediated production of inflammatory cytokines (IL‐6, IL‐12 and TNF‐α) in peripheral blood mononuclear cells.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial properties ofKalanchoe blossfeldiana: a focus on drug resistance with particular reference to quorum sensing-mediated bacterial biofilm formation

Sarkar

Mondal

Bera

et al. 2015

Journal of Pharmacy and Pharmacology

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Section: Discussionmentioning

confidence: 99%

Antimicrobial properties ofKalanchoe blossfeldiana: a focus on drug resistance with particular reference to quorum sensing-mediated bacterial biofilm formation

Sarkar

Mondal

Bera

et al. 2015

Journal of Pharmacy and Pharmacology

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“…Among these, compounds of cubebene series including cubebene, cubebenoate, and cubeneol have recently received great attention as a newly isolated active compound, although there are differences in the extraction method and chemical structure [ 21 , 22 ]. In particular, cubenenol used in this study is structurally similar to cubebenoate, although there are many differences in their functions [ 24 , 25 , 26 , 27 , 28 , 29 ]. The above two compounds show similar therapeutic effects in inflammation and sepsis, although each one has different therapeutic effects in various diseases [ 24 , 29 , 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…This compound induced p53-independent pathway-mediated apoptosis through the alternative regulation of Cas3, Bax, Bcl-2, and p53 proteins in hepatocellular carcinoma cells [ 28 ]. Furthermore, α-cubebenol inhibited immune cell apoptosis and the production of proinflammatory cytokines in a cecal ligation and puncture (CLP) challenge-induced sepsis model [ 29 ]. On the other hand, no studies have provided scientific evidence on the anti-obesity effects of α-cubebenol in pre- and mature adipocytes until now.…”

Section: Introductionmentioning

confidence: 99%

Anti-Obesity Effect of α-Cubebenol Isolated from Schisandra chinensis in 3T3-L1 Adipocytes

et al. 2021

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The efficacy of α-cubebenol isolated from Schisandra chinensis has been studied in several diseases, including cecal ligation, puncture challenge-induced sepsis, and degranulation of neutrophils. To identify the novel functions of α-cubebenol on lipid metabolism, alterations on the regulation of lipogenesis, lipolysis, and inflammatory response were observed in 3T3-L1 adipocytes treated with α-cubebenol. Most lipogenic targets, including lipid accumulation, level of lipogenic transcription factors, and expression of lipogenic regulators, were suppressed in MDI (3-isobutyl-1-methylxanthine, dexamethasone, and insulin)-stimulated 3T3-L1 adipocytes treated with α-cubebenol without significant cytotoxicity. In addition, similar inhibition effects were observed in the iNOS-induced COX-2 mediated pathway and NLRP3 inflammasome pathway of MDI-stimulated 3T3-L1 cells treated with α-cubebenol. Lipolytic targets, such as cAMP concentration, expression of adenylyl cyclase and PDE4, and their downstream signaling pathway, in MDI-stimulated 3T3-L1 cells were stimulated by the α-cubebenol treatment. The levels of transcription factors and related proteins for β-oxidation were significantly higher in the MDI + α-cubebenol treated group than in the MDI + Vehicle treated group. These results show that α-cubebenol has a novel role as a lipogenesis inhibitor, lipolysis and β-oxidation stimulator, and inflammasome suppressor in MDI-stimulated 3T3-L1 adipocytes.

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“…A study by Li revealed that honokiol could antagonize sepsis-associated acute kidney injury partially through blocking the NF-κB signaling pathway (30). The progress of septic shock can be reversed by α-iso-cubebenol, which triggers numerous protective downstream signaling pathways, enhancing microbial killing and maintaining organ function and leukocyte survival (31). Meanwhile, wild bitter gourd can reduce fat accumulation and improve low blood glucose in sepsis, as well as reduce inflammatory markers in mice with sepsis (32).…”

Section: Discussionmentioning

confidence: 99%

The protective effect of vitexinin septic encephalopathy by reducing leukocyte-endothelial adhesion and inflammatory response

et al. 2020

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Background: Despite advances in therapeutic strategies and critical care management, septic encephalopathy (SE) is still a leading cause of infection-associated death in intensive care units (ICUs).Vitexin, a flavonoids compound, exerts and anti-inflammatory effect through inhibition of proinflammatory cytokines and signaling pathways. This study aimed to explore the anti-inflammatory effects of vitexin in SE and the underlying mechanisms.Methods: An SE-inducedC57BL/6 mouse model was established via cecal ligation and puncture (CLP).Western blotting was performed to evaluate the protein expression levels of Chemokine (C-X-C motif) ligand 1 (CXCL1), fractalkine (CX3CL1), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, NF-κB p65, p-NF-κB p65, and tumor necrosis factor-α (TNF-α). Flow cytometry was used to detect the expressions ofCD11a/CD18, CD11b/CD18, ICAM-1, and adherent leukocyte. The expression of ICAM-1 was detected by immunohistochemistry. An enzyme-linked immunosorbent assay was performed to evaluate the expression of monocyte chemotactic protein-1 (MCP-1), Interleukin (IL)-6, IL-8, and IL-10.Results: In this study, we found that vitexin significantly downregulated the expression of brain endothelial chemokines CXCL1 and CX3CL1 in CLP mice, exerting a potential anti-inflammatory against SE. Our data also showed that vitexin alleviated SE primarily by relying on reducing leukocyte-endothelial adhesion via the mediation of adhesion molecules. Moreover, vitexin suppressed the expression of proinflammatory cytokines, such as MCP-1, IL-6, IL-8, TNF-α, and NF-κB p65, in the CLP mice, while the expression of the anti-inflammatory cytokine IL-10 was elevated.Conclusions: Overall, our study demonstrated the protective effect vitexin exerts in SE by reducing leukocyte-endothelial adhesion and inflammatory response. These findings offer a molecular basis for the potential application of vitexin in the treatment of SE and other inflammatory-mediated and immunemediated disorders.

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Therapeutic effects of α-iso-cubebenol, a natural compound isolated from the Schisandra chinensis fruit, against sepsis

Cited by 12 publications

References 20 publications

Antimicrobial properties ofKalanchoe blossfeldiana: a focus on drug resistance with particular reference to quorum sensing-mediated bacterial biofilm formation

Antimicrobial properties ofKalanchoe blossfeldiana: a focus on drug resistance with particular reference to quorum sensing-mediated bacterial biofilm formation

Anti-Obesity Effect of α-Cubebenol Isolated from Schisandra chinensis in 3T3-L1 Adipocytes

The protective effect of vitexinin septic encephalopathy by reducing leukocyte-endothelial adhesion and inflammatory response

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