Therapeutic effects of zerumbone in an alkali-burned corneal wound healing model

Kim, Jong Won; Jeong, Hyuneui; Yang, Myeon‐Sik; Lim, Chae Woong; Kim, Bumseok

doi:10.1016/j.intimp.2017.05.005

Cited by 18 publications

(11 citation statements)

References 33 publications

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“…Zerumbone, a cyclic sesquiterpene derived from rhizomes of wild ginger, inhibits STAT3 phosphorylation and decreases mRNA expression of fibrotic genes such as a-SMA and TGF-b1, but not TGF-b2, in alkali-injured corneas of mice. Treatment with zerumbone reduced corneal neovascularization and fibrosis, thus promoting wound healing (Kim et al, 2017a).…”

Section: G Janus Kinase/signal Transducer and Activator Of Transcripmentioning

confidence: 99%

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

et al. 2020

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Section: G Janus Kinase/signal Transducer and Activator Of Transcripmentioning

confidence: 99%

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

et al. 2020

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“…Presently, zerumbone has been extensively studied for its antitumor, anti-inflammatory, antimicrobial, and anti-angiogenic activities (Rahman et al, 2014). Kim et al (2017b) recently examined the effects of zerumbone on chemokine-related macrophage infiltration in the corneal wound healing process. Their results indicated that zerumbone prevented angiogenesis and fibrosis through the inhibition of inflammatory cells activation.…”

Section: Corneal Wound Healingmentioning

confidence: 99%

Corneal Repair and Regeneration: Current Concepts and Future Directions

Mobaraki

Abbasi

Vandchali

et al. 2019

Front. Bioeng. Biotechnol.

109

100

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The cornea is a unique tissue and the most powerful focusing element of the eye, known as a window to the eye. Infectious or non-infectious diseases might cause severe visual impairments that need medical intervention to restore patients' vision. The most prominent characteristics of the cornea are its mechanical strength and transparency, which are indeed the most important criteria considerations when reconstructing the injured cornea. Corneal strength comes from about 200 collagen lamellae which criss-cross the cornea in different directions and comprise nearly 90% of the thickness of the cornea. Regarding corneal transparency, the specific characteristics of the cornea include its immune and angiogenic privilege besides its limbus zone. On the other hand, angiogenic privilege involves several active cascades in which anti-angiogenic factors are produced to compensate for the enhanced production of proangiogenic factors after wound healing. Limbus of the cornea forms a border between the corneal and conjunctival epithelium, and its limbal stem cells (LSCs) are essential in maintenance and repair of the adult cornea through its support of corneal epithelial tissue repair and regeneration. As a result, the main factors which threaten the corneal clarity are inflammatory reactions, neovascularization, and limbal deficiency. In fact, the influx of inflammatory cells causes scar formation and destruction of the limbus zone. Current studies about wound healing treatment focus on corneal characteristics such as the immune response, angiogenesis, and cell signaling. In this review, studied topics related to wound healing and new approaches in cornea regeneration, which are mostly related to the criteria mentioned above, will be discussed.

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“…One of the key mechanisms concerning the effect of ZER on anticancer activity is that ZER can promote tumor cell apoptosis via various signaling molecules such as caspases and B‐cell lymphoma 2 (Bcl2) and its associated molecules (Prasannan et al, ). More recently, it has been documented that ZER has beneficial effects on inflammation‐related diseases such as pancreatitis, colitis, acute lung injury, and corneal wound (Ho et al, ; Kim, Jeong, Yang, Lim, & Kim, ; Murakami et al, ; Wenhong et al, ). Besides these effects, ZER has prophylactic effects on metabolic‐related diseases such as nonalcoholic fatty liver disease, diabetes, and its‐associated complications.…”

Section: Introductionmentioning

confidence: 99%

Dietary zerumbone, a sesquiterpene, ameliorates hepatotoxin‐mediated acute and chronic liver injury in mice

Kim

Yang

Jeong

et al. 2019

Phytotherapy Research

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Acute liver injury (ALI) is a life‐threatening clinical syndrome. Long‐lasting liver injury can lead to chronic hepatic inflammation and fibrogenic responses. Zerumbone (ZER), the main constituent of rhizomes of Zingiber zerumbet Smith, has a variety of functions including anticancer activity. We investigated the role of ZER on the progression of hepatotoxin‐induced liver injury. Single or repeated injection of CCl4 was used to induce acute or chronic liver injury, respectively. Mice were orally administered with ZER (10, 50 mg/kg) during the experimental period. Histopathologic analysis and serum biochemical levels revealed that ZER had hepatoprotective activities against ALI. Similar effects of ZER on injured livers were confirmed by analyses of inflammation and apoptosis‐related genes. Western blot analysis showed that protein levels of apoptotic molecules were decreased, whereas antiapoptotic protein levels were conversely increased in injured livers treated with ZER. Furthermore, chronic liver injury and its associated fibrogenesis in mice were reduced by ZER treatment. These findings from our in vivo experiments further indicate that ZER could alleviate hepatocellular toxicity and inhibit activation of primary hepatic stellate cells. Our results suggest that ZER might have potential as a safe and prophylactic alternative to prevent acute and chronic liver injury.

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Therapeutic effects of zerumbone in an alkali-burned corneal wound healing model

Cited by 18 publications

References 33 publications

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Corneal Repair and Regeneration: Current Concepts and Future Directions

Dietary zerumbone, a sesquiterpene, ameliorates hepatotoxin‐mediated acute and chronic liver injury in mice

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