Therapeutic Effects of Transplantation of Lyophilized and Radiation-Sterilized, Allogeneic Bone

Komender, J; Malczewska, Hanna; Komender, A

doi:10.1097/00003086-199111000-00007

Cited by 12 publications

(5 citation statements)

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“…In Poland, retrospective studies were undertaken on a significant number of patients who received lyophilised (1010 cases - Komender et al 1991, and435 cases -Zasacki 1991) or deep frozen (1125 cases - Marczynski et al 1997) bone allografts prepared at the Central Tissue Bank in Warsaw and irradiated with a dose of 33-35 kGy. Long-term follow-up (2-10 years after transplantation) was performed in co-operation with three large orthopaedic centres.…”

Section: Clinical Efficacy Of Radiation-sterilised Bone Allograftsmentioning

confidence: 99%

Irradiation as a Safety Procedure in Tissue Banking

Dziedzic‐Goclawska

Kamiński

Uhrynowska-Tyszkiewicz

et al. 2005

Cell Tissue Banking

168

118

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The Central Tissue Bank in Warsaw was established in 1963 and since then ionising radiation has been routinely applied to sterilise tissue grafts. Connective tissue grafts such as bone, cartilage, tendons, sclera, pericardium, skin, acellular dermis and amnion irradiated with a dose of 35 kGy in a (60)Co source and/or with an electron beam 10 MeV accelerator are prepared in our Tissue Bank and two other multi-tissue banks operating in Poland. Over 250,000 radiation-sterilised tissue grafts have been prepared and used in hospitals throughout Poland and no infectious disease transmission or other adverse post-transplantation reactions have been reported up to today. It should be kept in mind however, that high doses of ionising radiation can evoke numerous chemical and physical changes that may affect the biological quality of tissue allografts. Therefore, interdisciplinary research has been undertaken at the Central Tissue Bank in Warsaw to establish the origin and stability of free radicals and other paramagnetic entities induced by irradiation in bone. The effects of various preservation procedures (e.g. lyophilisation, deep-freezing) and irradiation conditions (doses, temperature of irradiation) on the osteoinductive potential and mechanical properties of bone and on the degradation of collagen, a major constituent of all connective tissue grafts, have been also studied. The results of these studies indicate that radiation-induced changes can be diminished by modification of tissue preservation methods and that, to some extent, it is possible to reduce undesired radiation-induced damage to the tissue grafts.

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Section: Clinical Efficacy Of Radiation-sterilised Bone Allograftsmentioning

confidence: 99%

Irradiation as a Safety Procedure in Tissue Banking

Dziedzic‐Goclawska

Kamiński

Uhrynowska-Tyszkiewicz

et al. 2005

Cell Tissue Banking

168

118

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“…Kommender ( 12) berich tet a uch übe r Erfolge bei T ra nsp la ntation mit gcfri erge trock net em und be stra hltem Kn och e n. D ie E rgeb nisse ze ige n. daß e ine e rfol greiche Knoc he ntra nspla nt at io n so wo hl mit ste ril ge wo nne ne m tiefg efror en em Knoche n als a uch mit gefrie rge tro ckne te m und se kundä r durch Bestrahlun g sterilisiertem Knoc hen durch geführt werde n kann. In der Literatur ist jedoch we nig üb er die notwendigen Reh yd rat at io nszeiten vo n Iyo phil isierte rn Knoche n berichtet wo rd e n.…”

Section: Einleit Ungunclassified

Einfluß verschiedener Rehydratationszeiten auf die Stabilität und den Wassergehalt von Knochentransplantaten nach Gefriertrocknung, Gammasterilisation und Fettextraktion

Jerosch

Granrath²,

Clahsen³

et al. 2008

Z Orthop Ihre Grenzgeb

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Based on the presented data rehydration time of 0.5 hours seems to have no disadvantage compared to longer time periods concerning breaking strength. Therefore a longer intraoperative time period seems not to be necessary. This is of advantage for a possible secondary contamination while the allograft is rehydrated. Rehydration after lipid extraction is more effective than rehydration after lyophilization alone. However, the question whether lipid extraction alter bone stability has to be proved in further studies.

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“…Such process is called as the creep‐substitution. Generally, the survival rate of deep‐freezing/freeze drying radiation allograft bone can be up to 80–90% .…”

Section: Introductionmentioning

confidence: 99%