Abstract:Superoxide anion (O2
•−) is overproduced in joint inflammation, rheumatoid arthritis, and osteoarthritis. Increased O2
•− production leads to tissue damage, articular degeneration, and pain. In these conditions, the physiological defense against O2
•−, superoxide dismutases (SOD) are decreased. The MnII complex MnL4 is a potent SOD mimetic, and in this study it was tested in inflammatory and osteoarticular rat pain models. In vivo protocols were approved by the animal Ethical Committee of the University of …
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