Therapeutic effects of the aromatase inhibitor fadrozole hydrochloride in advanced breast cancer

Bonnefoi, Hervé; Smith, IE; Dowsett, Mitchell; Trunet, P; Houston, Stephen; Luz, Raymundo; Rubens, Robert; Coombes, R. Charles; Powles, T. J.

doi:10.1038/bjc.1996.93

Cited by 28 publications

(9 citation statements)

References 20 publications

(20 reference statements)

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“…One consequence of the reduced forebrain size is then the shrinking of the HVC after aromatase inhibition. This effect is probably due to estrogen deprivation because fadrozole is a rather specific aromatase inhibitor with few known short‐term side effects (Wade et al, 1994; Bonnefoi et al, 1996; Bhatnagar et al, 2001). Aromatase activity is very abundant in many forebrain areas (Schlinger, 1997; Balthazart and Ball, 1998; Metzdorf et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Differential expression pattern and steroid hormone sensitivity of SNAP‐25 and synaptoporin mRNA in the telencephalic song control nucleus HVC of the zebra finch

Voigt

Metzdorf

Gahr

2004

J of Comparative Neurology

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Gonadal steroid hormones play an important role in the process of sexual differentiation of brain areas and behavior such as singing and song learning in songbirds. These hormones affect behavior controlling circuits on both the gross morphological and ultrastructural levels. Here we study whether the expression of genes coding for synaptic proteins is sensitive to gonadal steroid hormones and whether such altered expression coincides with changes in brain area size. We treated adult male zebra finches with the aromatase inhibitor fadrozole, to reduce estrogen synthesis and analyzed the mRNA expression of the synaptic proteins synaptoporin (SPO) and synaptosomal-associated protein 25 kDa (SNAP-25) in song control areas and surrounding tissues of adult male zebra finches. SPO and SNAP-25 are differently expressed throughout the song system. Generally, the telencephalic song nuclei expressed SNAP-25 at high intensity whereas SPO expression was area-specific. Elevated levels of SNAP-25 mRNA were present in the nucleus hyperstriatalis ventrale pars caudale (HVC) and in the robust nucleus of the archistriatum (RA). SPO mRNA was found in moderate levels in the HVC, in low levels in the lateral nucleus magnocellularis (lMAN) and Area X, and was absent in the RA. The treatment significantly increased the mRNA level of SPO in the HVC, whereas SNAP-25 expression level was not affected. These expression patterns are not explained by the decrease of HVC volume after treatment. The decreased HVC size is not area-specific but correlates with an overall reduction in size and an overall increase in cell density of the forebrain.

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Section: Discussionmentioning

confidence: 99%

Differential expression pattern and steroid hormone sensitivity of SNAP‐25 and synaptoporin mRNA in the telencephalic song control nucleus HVC of the zebra finch

Voigt

Metzdorf

Gahr

2004

J of Comparative Neurology

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Section: Introductionmentioning

confidence: 92%

“…While aldosterone levels appear to have remained unchanged during fadrozole therapy, minor reductions in sodium and increases in potassium have been noted in some studies ( 27, 28, 33). Cortisol production and thyroid hormone levels have been unaffected by fadrozole ( 27, 33). A significant reduction in cortisol levels occurred after 2 weeks of 0·5 mg letrozole per day but the concentrations remained within normal limits.…”

Section: Introductionmentioning

confidence: 92%

“…Phase I and II trials with the non‐steroidal aromatase inhibitors revealed objective responses ranging from 4% to 36%, depending upon baseline prognostic characteristics ( 10, 13, 21, 22, 28–30, 33–35). The objective response rate includes both complete responses (defined as the complete disappearance of disease for at least 4 weeks) and partial responses (defined as at least a 50% reduction in measurable lesions and stabilization of unmeasurable tissue) ( 37, 42).…”

Section: Introductionmentioning

confidence: 99%

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A review of the newer aromatase inhibitors in the management of metastatic breast cancer

Reddy¹

1998

J Clin Pharm Ther

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“…A statistically nonsignificant fall in aldosterone levels (p = 0.06) during treatment was seen but no electrolyte changes were observed. The clinical efficacy of fadrozole hydrochloride was studied by Bonnefoi et al (1996) in this same group of women and an objective response rate of 17% was seen with no complete re-sponders. Fifteen patients (21 %) had stable disease and 45 patients (63%) had progressive disease.…”

Section: Fadrozole Hydrochloridementioning

confidence: 99%

Aromatase Inhibitors and Their Use in the Adjuvant Setting

Coombes

1998

Recent Results in Cancer Research

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Therapeutic effects of the aromatase inhibitor fadrozole hydrochloride in advanced breast cancer

Cited by 28 publications

References 20 publications

Differential expression pattern and steroid hormone sensitivity of SNAP‐25 and synaptoporin mRNA in the telencephalic song control nucleus HVC of the zebra finch

Differential expression pattern and steroid hormone sensitivity of SNAP‐25 and synaptoporin mRNA in the telencephalic song control nucleus HVC of the zebra finch

A review of the newer aromatase inhibitors in the management of metastatic breast cancer

Aromatase Inhibitors and Their Use in the Adjuvant Setting

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