Therapeutic effects of tea polyphenol-loaded nanoparticles coated with platelet membranes on LPS-induced lung injury

Hua, Jing; Zhao, Yunfeng; Yao, Yinlian; Zhao, Jimin; Luo, Renxing; Fan, Shilong; Wei, Yanlan; Ouyang, Suidong; Peng, Wanqing; Zhang, Yumin; Pi, Jiang; Huang, Gonghua

doi:10.1039/d3bm00802a

Cited by 8 publications

(1 citation statement)

References 36 publications

(48 reference statements)

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“…2B, TP concentrations below 128 µg/mL exhibited excellent cell viability in HBE cells, suggesting this as the safe range for TP treatment. Consistent with a previously published study [22] , a concentration of 100 µg/mL of TP and its nanoparticles was chosen for in vitro experiments.…”

Section: Bioavailability Biosafety and Biocompatibility Evaluation Of...mentioning

confidence: 99%

Targeting ROS production by Tea Polyphenols biomimetic nanoparticles for asthma treatment in mice

Ouyang,

Lu,

et al. 2024

Preprint

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Asthma presents as a chronic allergic condition characterized by airway inflammation, increased responsiveness, and mucus accumulation. Reactive oxygen species (ROS) are central to its inflammatory cascade and pathology. Hence, we theorized that antioxidants could offer a promising therapeutic strategy for house dust mite (HDM)-induced asthma. Our study reveals that Tea Polyphenols (TPs) encapsulated in biocompatible nanoparticles, enveloped with platelet membranes (PM@TP/NPs), effectively alleviated HDM-induced asthma by suppressing ROS production and modulating the CCL2/MAPK signaling pathway. Notably, PM@TP/NPs exhibited excellent biocompatibility and safety, with enhanced lung retention compared to free TP. In vitro experiments demonstrated that PM@TP/NPs curbed HDM-induced inflammation in human bronchial epithelial (HBE) cells by reducing ROS levels, Ccl2 mRNA expression, and inhibiting the MAPK pathway. In an HDM-induced mouse asthma model, inhalation of PM@TP/NPs significantly attenuated lung inflammation, characterized by reduced eosinophil infiltration and secretion of type 2 pro-inflammatory factors. Furthermore, PM@TP/NPs enhanced ROS scavenging capacity while concurrently suppressing the CCL2/MAPK pathway in the lungs of asthmatic mice. Collectively, our findings propose PM@TP/NPs as a novel therapeutic strategy for asthma, targeting ROS production and inflammation for potential clinical application.

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Section: Bioavailability Biosafety and Biocompatibility Evaluation Of...mentioning

confidence: 99%

Targeting ROS production by Tea Polyphenols biomimetic nanoparticles for asthma treatment in mice

Ouyang,

Lu,

et al. 2024

Preprint

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show abstract

Pulmonary RNA interference against acute lung injury mediated by mucus- and cell-penetrating nanocomplexes

Zhang,

Shen,

Liang

et al. 2024

Acta Biomaterialia

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Intratracheal delivery of macrophage targeted Celastrol-loaded PLGA nanoparticles for enhanced anti-inflammatory efficacy in acute lung injury mice

Yao,

Fan,

Fan

et al. 2024

European Journal of Pharmaceutics and Biopharmaceutics

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Therapeutic effects of tea polyphenol-loaded nanoparticles coated with platelet membranes on LPS-induced lung injury

Abstract: Patients with ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) are often septic and with poor prognosis, which leads to a high mortality rate of 25–40%. Despite the advances in...

Cited by 8 publications

References 36 publications

Targeting ROS production by Tea Polyphenols biomimetic nanoparticles for asthma treatment in mice

Targeting ROS production by Tea Polyphenols biomimetic nanoparticles for asthma treatment in mice

Pulmonary RNA interference against acute lung injury mediated by mucus- and cell-penetrating nanocomplexes

Intratracheal delivery of macrophage targeted Celastrol-loaded PLGA nanoparticles for enhanced anti-inflammatory efficacy in acute lung injury mice

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