Therapeutic effects of pindolol on behavioral disturbances associated with organic brain disease: A double-blind study

Greendyke, Robert M.; Kanter, Donald R.

doi:10.1097/00001199-198703000-00012

Cited by 27 publications

(33 citation statements)

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“…A few small placebo-controlled trials have reported efficacy of propranolol and pindolol for impulsive aggression in populations with organic brain injury [52,53]. The efficacy of psychostimulants on impulsivity is still unclear.…”

Section: Pharmacological Treatment Of Impulsivitymentioning

confidence: 99%

Singing under the impulsiveness: impulsivity in psychiatric disorders

Kulacaoğlu

Köse

2017

Psychiatry and Clinical Psychopharmacology

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Impulsivity is a key feature of numerous psychiatric disorders. This paper reviews the recent evidences on the impulsivity in elderly, relationship between impulsivity and borderline personality disorder (BPD) with attention-deficit/hyperactivity disorder (ADHD), impulsivity with anxiety and mood disorders, and the psychopharmacological approaches to impulsivity evaluating previously published studies. A literature review of the theoretical bases of the relationship between psychiatric disorders and impulsivity is presented. Measurements of impulsivity and neurobiological hypothesis are defined. Treatment approaches are discussed. Previous researches have shown significantly higher levels of impulsivity among patients with BPD, ADHD, anxiety, and mood disorders. In addition, older adults could be more impulsive than younger adults. But the nature of this relationship remains unclear. This is probably due to the fact that there is much overlap between them. Impulsivity is a risk for suicidality and influences pathogenesis, course, clinical severity of many psychiatric disorders. Pharmacological interventions for treating impulsivity should be incorporated into treatment plans for these disorders. Identifying the role of pharmacological interventions in modulating the development of trait impulsivity may prevent progression to psychiatric disorders and associated adverse consequences. ARTICLE HISTORY

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Section: Pharmacological Treatment Of Impulsivitymentioning

confidence: 99%

Singing under the impulsiveness: impulsivity in psychiatric disorders

Kulacaoğlu

Köse

2017

Psychiatry and Clinical Psychopharmacology

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“…Beta-blockers were shown to decrease the intensity of agitated episodes and the frequency of assault attempts in four randomized controlled trials with subjects with TBI identified in a recent Cochrane review [106][107][108][109][110]. All trials were small in sample size (up to 21 subjects).…”

Section: Beta-blockersmentioning

confidence: 99%

Pharmacological management of neurobehavioral disorders following traumatic brain injuryA state-of the-art review

Chew

Zafonte²

2009

JRRD

161

103

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Abstract-Pharmacological management of neurobehavioral disorders following traumatic brain injury (TBI) is common practice. However, the evidence available to guide this practice remains sparse. This review summarizes, in brief, the state of knowledge, organized via a time continuum from injury as well as by symptom complex. The areas of neuroprotection, hypoarousal, attention and memory deficits, aggression, agitation, depression, and mania are reviewed. The literature was searched with PubMed on the terms "traumatic brain injury" or "brain injury" with "pharmacology" (and the symptoms according to which this review is arranged). Additional searches were conducted with the specific symptoms as search terms, crossed with the therapeutic agents or drug classes discussed. Where a paucity of prospective data exists, case reports and retrospective studies are included. Studies to date have yielded minimal positive evidence for enhancing function, memory, and behavior after TBI. No single agent likely will become sentinel in the recovery process, and combination therapy in the acute and postacute settings are required. A need exists to further define the role of psychopharmacology in postacute TBI medicine and the specific characteristics of subpopulations who might benefit.

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“…Propranolol [89] Case report, 1 Worsened, underlying depression unmasked (patient with a history of depression)? Propanolol [90] Case reports, 3 Improved; one developed hypotension, two on haloperidol also Pindolol [91] Double blind, placebo-controlled crossover, 1 with HD (10 other patients with organic brain syndromes also studied)…”

Section: Comments and Outcome On Target Symptomsmentioning

confidence: 99%

An overview of psychiatric symptoms in Huntington’s disease

Anderson

Marder

2001

Curr Psychiatry Rep

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Huntington's disease (HD) is an inherited autosomal dominant disorder characterized by neurologic, cognitive, and psychiatric symptomatology. Psychiatric symptoms in HD are often amenable to treatment, and relief of these symptoms may provide significant improvement in quality of life. This review will briefly describe neurologic, neuropsychologic and brain imaging data, and then review psychiatric syndromes seen in HD and their treatment.

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Therapeutic effects of pindolol on behavioral disturbances associated with organic brain disease: A double-blind study

Cited by 27 publications

References 0 publications

Singing under the impulsiveness: impulsivity in psychiatric disorders

Singing under the impulsiveness: impulsivity in psychiatric disorders

Pharmacological management of neurobehavioral disorders following traumatic brain injuryA state-of the-art review

An overview of psychiatric symptoms in Huntington’s disease

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