Therapeutic effects of orexin-A in sepsis-associated encephalopathy in mice
Jing Guo,
Zhuo Kong,
Sha Yang
et al.
Abstract:Background
Sepsis-associated encephalopathy (SAE) causes acute and long-term cognitive deficits. However, information on the prevention and treatment of cognitive dysfunction after sepsis is limited. The neuropeptide orexin-A (OXA) has been shown to play a protective role against neurological diseases by modulating the inflammatory response through the activation of OXR1 and OXR2 receptors. However, the role of OXA in mediating the neuroprotective effects of SAE has not yet been reported.
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