Therapeutic effects of one-year alendronate treatment in three cases of osteoporosis with parietal thinning of skull

Takata, Shigeo; Sugiyama, Takao; Yoshida, S.; Hayashi, Fumio; Yasui, Natsuo

doi:10.2152/jmi.55.297

Cited by 13 publications

(18 citation statements)

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“…However, our observations revealed that basal calvarial bone thickness was significantly reduced in OVX mice, confirming previous findings [10,45]. This is consistent with bone resorption of the skull and subsequent parietal bone thinning observed in postmenopausal osteoporotic women [46]. Therefore, the current experimental protocol likely mimicked comparable cellular and biologic bone responses in OVX mice that occur in the early postmenopausal period.…”

Section: Discussionsupporting

confidence: 91%

Oestrogen deficiency modulates particle-induced osteolysis

et al. 2011

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IntroductionPostmenopausal osteoporosis may modulate bone response to wear debris. In this article, we evaluate the influence of oestrogen deficiency on experimental particle-induced osteolysis.MethodsPolyethylene (PE) particles were implanted onto the calvaria of normal controls, sham-ovariectomized (OVX), OVX mice and OVX mice supplemented with oestrogen (OVX+E). After 14 days, seven skulls per group were analyzed using a high-resolution micro-computed tomography (micro-CT) and histomorphometry, and for tartrate-specific alkaline phosphatase. Five calvariae per group were cultured for the assay of IL-1β, IL-6, TNF-α and receptor activator of the nuclear factor κB (RANKL) secretion using quantitative ELISA. Serum IL-6 concentrations were obtained. The expression of RANKL and osteoprotegerin (OPG) mRNA were evaluated using real-time PCR.ResultsAs assessed by μCT and by histomorphometry, PE particles induced extensive bone resorption and an intense inflammatory reaction in normal controls, sham-OVX and OVX+E mice, but not in the OVX mice group. In normal controls, sham-OVX and OVX+E mice, PE particles induced an increase in serum IL-6, in TNF-α and RANKL local concentrations, and resulted in a significant increase in RANKL/OPG messenger RNA (mRNA) ratio. Conversely, these parameters remained unchanged in OVX mice after PE implantation.ConclusionsOestrogen privation in the osteolysis murine model ultimately attenuated osteolytic response to PE particles, suggesting a protective effect. This paradoxical phenomenon was associated with a down-regulation of pro-resorptive cytokines. It is hypothesized that excessive inflammatory response was controlled, illustrated by the absence of increase of serum IL-6 in OVX mice after PE implantation.

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Section: Discussionsupporting

confidence: 91%

Oestrogen deficiency modulates particle-induced osteolysis

et al. 2011

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“…However, our observations revealed that basal calvarial bone thickness was significantly reduced in OVX mice, confirming previous findings 18, 20. This is consistent with bone resorption of the skull and subsequent parietal bone thinning observed in postmenopausal osteoporotic women 35. Therefore, the current experimental protocol likely mimicked comparable cellular and biologic bone responses in OVX mice that occur in the early postmenopausal period.…”

Section: Discussionsupporting

confidence: 91%

Decrease in particle‐induced osteolysis in ovariectomized mice

Nich

Marchadier²,

Sedel

et al. 2009

Journal Orthopaedic Research

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Postmenopausal osteoporosis is a common disorder that results from increased osteoclastic activity caused by estrogen deficiency. Whether postmenopausal bone remodeling can alter the response to particulate debris is unknown. The purpose of this study was to evaluate the bone response to polyethylene particles in an ovariectomized murine model. Polyethylene particles were implanted onto the calvaria of seven control mice and seven ovariectomized (OVX) mice, as compared with calvaria from sham-operated and OVX mice. Calvaria were harvested after 14 days. Skulls were analyzed with a high-resolution micro-CT and by histomorphometry after staining with Stevenel blue and picrofuschine, and for tartrate-specific alkaline phosphatase. As assessed by micro-CT, particle implantation induced a significant decrease in bone thickness in control mice, while bone thickness remained stable in OVX mice. In particle-implanted animals, the osteoclast number was 2.84 AE 0.3 in control mice and 1.74 AE 0.22 in OVX mice. Mean bone loss was À12% AE 1.9% in control mice and À4.7% AE 1.7% in OVX animals. The reduction of osteolytic response suggests that ovariectomy may have a protective role against particle-induced bone resorption. ß

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“…Existem dois tipos de adelgaçamento: achatado e sulcado. Na maioria dos casos o adelgaçamento é do tipo achatado 7 . Acomete mais o gênero feminino, na proporção de 1.9:1 masculino 2 .…”

Section: Discussionunclassified

“…A localização unilateral é rara 10 , fato este observado em um dos nossos pacientes. Portanto, o exame de TC com janela óssea pode evidenciar o comprometimento da tabua óssea externa e da 7 , estudaram os efeitos terapêuticos do tratamento com alendronato em pacientes osteoporóticos com adelgaçamento do osso parietal e os resultados mostraram que a reabsorção óssea acelerada faz parte do processo fisiopatológico relacionado com o adelgaçamento ósseo parietal. Segundo Yilmaz et al 10 , não existe tratamento específico para esta doença.…”

Section: Discussionunclassified

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Adelgaçamento dos Ossos Parietais

Pereira¹,

Pereira²,

Dezena³

et al. 2018

jbnc

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RESUMOIntrodução: A ocorrência de adelgaçamento dos ossos parietais tem sido pouco descrita na literatura médica. Localiza-se na porção posteromedial do osso parietal. Sua prevalência é de 0,25 a 0,8% da população geral. acometendo mais o sexo feminino. Sua etiopatogenia não está esclarecida e não existe tratamento especifico. Métodos: Foram analisados os parâmetros de sexo, idade e causas. Ambos casos foram do gênero feminino e as idades foram 68 e 78 anos. Resultados: Nossos casos foram achados incidentais de imagem, sendo em um caso devido a traumatismo cranioencefálico e outra por cefaleia crônica. Conclusão: O adelgaçamento dos ossos parietais tem sido incomum, encontra-se associado com várias doenças e não existe tratamento especifico. Palavras-chave: Crânio; Osso parietal; Tomografia computadorizada.ABSTRACT Introduction: The occurrence of thinning of the parietal bones has been poorly described in the medical literature. Located in the posteromedial portion of the parietal bone its prevalence is 0.25 to 0.8 % of the general population, and affects more females. Pathogenesis is not clear and there is no specific treatment. Methods: Sex, age and causes were analyzed. Both cases were female and ages of 68 and 78 years. Results: Our cases were incidental findings in analysis of image; in one case due to head trauma and the other chronic headache. Conclusion: The thinning of the parietal bones has been unusual. It is associated with various diseases and there is no specific treatment.

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Therapeutic effects of one-year alendronate treatment in three cases of osteoporosis with parietal thinning of skull

Cited by 13 publications

References 5 publications

Oestrogen deficiency modulates particle-induced osteolysis

Oestrogen deficiency modulates particle-induced osteolysis

Decrease in particle‐induced osteolysis in ovariectomized mice

Adelgaçamento dos Ossos Parietais

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