Therapeutic Effects of Matrine on Primary and Metastatic Breast Cancer

Li, Hali; Tan, Gang; Jiang, Xian; Qiao, Haiquan; Pan, Shanghua; Jiang, Hongchi; Kanwar, Jagat R.; Sun, Xueying

doi:10.1142/s0192415x10008512

Cited by 58 publications

(39 citation statements)

References 32 publications

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“…2), which is consistent with reported findings (57)(58)(59). previous studies demonstrated that Beclin 1 gene transfer decreased the rates of cell proliferation in human breast carcinoma cells and colon cancer cells (34,60), and Beclin 1 heterozygous disruption results in increased cellular proliferation (35).…”

Section: Discussionsupporting

confidence: 93%

Autophagy is involved in anticancer effects of matrine on SGC-7901 human gastric cancer cells

Zhang

Chen³

et al. 2011

Oncol Rep

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Abstract. Matrine has a wide range of pharmacological effects including antitumor activity in vitro and in vivo. Autophagy is closely associated with tumors and plays an important role in human tumor suppression, so inducing autophagy is a potential therapeutic strategy in adjuvant chemotherapy. the aim of this study was to investigate whether or not autophagy is involved in antitumor effects of matrine on human gastric cancer sgc-7901 cells, and to further elucidate the underlying molecular mechanisms. sulphorhodamine B (srB) assay was used to examine matrine's cytotoxicity against sgc-7901 gastric cancer cells. the effects of matrine on the cell cycle and apoptosis were measured by flow cytometry, and cellular morphology was observed under an inverted phase contrast microscope and transmission electron microscope. Monodansylcadaverine (MDc) staining was used to detect autophagy. the expression levels of Bax and Beclin 1 in sgc-7901 cells were monitored by real-time quantitative reverse transcription-polymerase chain reaction (rt-pcr). The results showed that matrine significantly inhibited the proliferation of sgc-7901 gastric cancer cells and induced g1-phase cell cycle arrest. Furthermore, both autophagy and apoptosis were activated during the matrine-induced death of sgc-7901 cells. Beclin 1 is involved in matrine-induced autophagy and the pro-apoptotic mechanisms of matrine may be associated with its up-regulation of Bax expression. These findings indicate that matrine is a potent antitumor agent for treating gastric cancer. the ability of matrine to induce autophagy underlines its potential utility as a new gastric cancer treatment modality.

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Section: Discussionsupporting

confidence: 93%

Autophagy is involved in anticancer effects of matrine on SGC-7901 human gastric cancer cells

Zhang

Chen³

et al. 2011

Oncol Rep

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“…The antitumor effect of matrine, an alkaloid extracted from Traditional Chinese herbal plants, has been studied in several cancer cell lines (3,(15)(16)(17)(18)20,21,(23)(24)(25). Matrine was found to inhibit the growth of cell lines derived from hepatoma, acute myeloid leukemia, melanoma, gastric carcinoma and lung cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Matrine has been previously shown to have an inhibitory effect on the growth of several cancer cell lines in vitro (3,(15)(16)(17)(18)20,21,(23)(24)(25). However, it has not been thoroughly explored whether the antitumor property of matrine is also effective on different lung cancer-derived cells.…”

Section: Growth Inhibitory Effect Of Matrine On Lung Cancer Cellsmentioning

confidence: 99%

“…These drug preparations have been prescribed for the treatment of cancer, arrhythmia (7)(8)(9), viral hepatitis (10)(11)(12), hepatic fibrosis (13) and skin diseases such as atopic dermatitis and eczema (14). In the past few years, a growing body of evidence suggests that matrine and oxymatrine may have some promising potential in cancer treatment as demonstrated by their tumoricidal effects on many cancer cell lines including those derived from gastric cancer, cervical cancer, leukemia, hepatocellular carcinoma, breast cancer, pancreatic cancer and lung cancer (3,(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). The major mechanisms that have been postulated to underlie the antitumor effects of matrine center on the regulation of apoptosis-and proliferation-related genes and proteins, such as Bcl-2 family members, caspases, E2F-1, Akt and Fas/FasL (23,(26)(27)(28)(29).…”

Section: Introductionmentioning

confidence: 99%

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Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway

Huang

Zhang

et al. 2014

Oncology Reports

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Abstract. Lung cancer is the leading cause of cancer-related mortality in humans. The prognosis for advanced lung cancer patients is extremely poor. Current standard care is rather ineffective for prolonging patient life while preserving satisfactory quality of life due to adverse side-effects. Matrine extracted from the traditional Chinese herbal plant Sophora flavescens was shown to induce cancer cell death in vitro. The aim of this study was to investigate the effect of matrine on the proliferation and apoptosis of lung cancer cells and the molecular basis of matrine-induced apoptosis. The results showed that matrine inhibited cell proliferation and induced apoptosis in lung cancer A549 and 95D cells in a dose-and time-dependent manner. The apoptotic effects of matrine on lung cancer cells appeared to act via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway and downregulation of the expression of the inhibitor of apoptosis protein (IAP) family proteins. Matrine exerts its cancer-killing effect via promoting apoptosis in lung cancer cells and may be a useful adjuvant therapeutic scheme for treating advanced lung cancer patients.

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“…1), one of the active alkaloids derived from the traditional Chinese herb Sophora alopecuroides L., has potential pharmacological effects including anticarcinogenic and chemopreventive activities on various malignancy cell lines, such as gastric, hepatic, lung, and breast cancers [21,22,23,24]. It also significantly inhibits the proliferation and induces apoptosis of human osteosarcoma and pancreatic cancer cells in vitro and in vivo [25,26].…”

Section: Introductionmentioning

confidence: 99%

Suppressive Effect of Matrine on Tumor Invasion in N-Butyl-N-(4-Hydroxybutyl)Nitrosamine-Induced Urinary Bladder Carcinogenesis

Gao¹,

Guo

Deng³

et al. 2014

Chemotherapy

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Aims: This study was designed to investigate the mechanisms and suppressive effects of matrine on the development of urinary bladder cancers induced by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in rats. Methods: Male Sprague-Dawley rats were given BBN (200 mg/rat) twice a week for a period of 8 weeks. Oral administration of matrine (50 and 100 mg/kg) was started 1 week before BBN exposure for 35 weeks. Half of each bladder was histopathologically analyzed and the remainder was extracted for protein analysis by Western blot. Results: The bladders of BBN-treated rats demonstrated progression from epithelial hyperplasia to papillary urothelial neoplasia and even poorly differentiated invasive cancer. Matrine (50 and 100 mg/kg) treatment decreased the formation of large bladder tumors by 31.6 and 21.1%, respectively. An incidence of cancer cells was detected in rats given BBN [70% (14/20)] and matrine [50 mg/kg: 68.4% (13/19) and 100 mg/kg: 57.9% (11/19), respectively]. The frequency of invasive tumors in the matrine treatment groups [50 mg/kg: 15.4% (2/13), 100 mg/kg: 9.1% (1/11)] was significantly lower than in the BBN-alone group [57% (8/14)]. Furthermore, oral administration of matrine (50 and 100 mg/kg) markedly attenuated the BBN-induced upregulation of bladder cyclooxygenase-2 (COX-2) expression and the elevation of bladder cytosolic phospholipase A2 (cPLA2) levels. Although the contents of 15-prostaglandin dehydrogenase (PGDH), which degrades PGE₂, were dramatically reduced by BBN, matrine exerted no effects on reduced PGDH contents. Conclusion: Our results suggest that matrine suppressed bladder tumor invasion in a rat model, and this might be primarily mediated through regulation of the protein contents, COX-2 and cPLA2 in the bladder.

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Therapeutic Effects of Matrine on Primary and Metastatic Breast Cancer

Cited by 58 publications

References 32 publications

Autophagy is involved in anticancer effects of matrine on SGC-7901 human gastric cancer cells

Autophagy is involved in anticancer effects of matrine on SGC-7901 human gastric cancer cells

Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway

Suppressive Effect of Matrine on Tumor Invasion in N-Butyl-N-(4-Hydroxybutyl)Nitrosamine-Induced Urinary Bladder Carcinogenesis

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