Therapeutic Effects of Lansoprazole on Peptic Ulcers in Elderly Patients

Murakami, Motonobu; Saita, Hiroshi; Takahashi, Youji; Kusaka, Satoshi; Asagoe, Kohsuke; Dekigai, Hiroshi; Matsumoto, Mituhiro; Seki, Makoto; Mizuno, Masahiro; Maeda, Sayako; Kita, Toru

doi:10.1097/00004836-199506002-00021

Cited by 14 publications

(7 citation statements)

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“…Data are now available demonstrating the benefit of curing H. pylori infection in elderly patients with H. pylori ‐associated peptic ulcer disease. Some controlled, short‐term studies performed on elderly patients reported that the treatment of H. pylori infection healed ulcers in over 95% of patients 6 and improved symptomatology in over 85% of patients 7 . Moreover, a 1‐year follow‐up study performed in elderly patients with peptic ulcers demonstrated that the eradication of H. pylori infection significantly improved the clinical outcome, reducing ulcer recurrence, symptomatology and gastritis activity 8 …”

Section: Indications For Treatment In the Elderlymentioning

confidence: 99%

An approach toHelicobacter pyloriinfection in the elderly

Pilotto

Malfertheiner

2002

Aliment Pharmacol Ther

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The prevalence of Helicobacter pylori infection increases with age world‐wide, reaching levels of 40–60% in asymptomatic elderly subjects and over 70% in elderly patients with gastroduodenal diseases. However, the percentage of H. pylori‐positive elderly patients who are treated for their infection remains very low. Data are now available that demonstrate the benefit of curing H. pylori infection in elderly patients with H. pylori‐associated peptic ulcer disease and severe chronic gastritis. Furthermore, the cure of H. pylori may prevent the progression of intestinal metaplasia and gastric atrophy. New studies are needed to clarify the role of eradication in elderly patients with non‐ulcer dyspepsia and gastro‐oesophageal reflux disease and in those who use non‐steroidal anti‐inflammatory drugs. H. pylori infection may be easily diagnosed by histological evaluation, rapid urease test or culture performed on gastric biopsies taken during endoscopy. However, the biopsy site must be carefully selected in elderly patients. For non‐invasive monitoring of H. pylori infection after treatment, the 13C‐urea breath test has significantly higher accuracy than serology in the elderly; further studies are needed to clarify the role of the H. pylori stool antigen test in old age. One‐week proton pump inhibitor‐based triple therapy regimens, including clarithromycin, amoxicillin and/or nitroimidazoles, are highly effective and well tolerated in elderly patients. Low doses of both proton pump inhibitors and clarithromycin (in combination with standard doses of amoxicillin or nitroimidazoles) are sufficient. Low compliance and antibiotic resistance are the main factors related to treatment failure in old age.

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Section: Indications For Treatment In the Elderlymentioning

confidence: 99%

An approach toHelicobacter pyloriinfection in the elderly

Pilotto

Malfertheiner

2002

Aliment Pharmacol Ther

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“…A total of 73 studies (57 papers and 16 abstracts) were included in this systematic overview. 10–82 Of those, 60 were randomized controlled trials. The study design was unclear or unstated in 13 reports.…”

Section: Resultsmentioning

confidence: 99%

Pooled analysis of Helicobacter pylori eradication regimes in Asia

Wang

Wong

Lam

2000

J of Gastro and Hepatol

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Proton pump inhibitor-based triple therapy with either clarithromycin, amoxycillin or metronidazole was one of the most commonly used and effective anti-H. pylori triple therapy regimens in Asia. The classical triple therapy with a bismuth, tetracycline and metronidazole combination has a similar efficacy. The results of anti-H. pylori treatment in Asia are not different from those in Western countries.

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“…Pilotto and colleagues demonstrated the short‐ and long‐term benefit of curing the infection in elderly. They observed a clinical significant improvement in terms of ulcer recurrence, symptomatology, and gastritis activity after eradication of H. pylori [21–23].…”

Section: Discussionmentioning

confidence: 99%