Therapeutic Effects of Ipomoea batatas L. Extract-Containing Capsule and Simvastatin Combination versus Simvastatin in Dyslipidemic Patients

Abstract

Purple sweet potato extract (PSPE) have been shown to exhibit antidyslipidemic effect, but the clinical effects of PSPE and statin combination has not been investigated. This study was aimed to reveal the effect of PSPE and statin combination on lipid profile, malondialdehyde (MDA) and superoxide dismutase (SOD) level in mild and moderate dyslipidemia cases. The study design was a limited clinical trial with a randomized pre and posttest control group design. Subjects were divided into simvastatin (control) group and simvastatin + PSPE capsules group (10 individuals per group). Both groups received simvastatin 20 mg daily (4 weeks), with the administration of PSPE capsules for the second group 400 mg/day, BID, 4 weeks). The aforementioned variables were subsequently analyzed using paired t-test and t-test, when appropriate. Better lipid profile improvements, lower MDA levels, and higher SOD level (p<0.05) were revealed in patients treated with simvastatin + PSPE compared to simvastatin alone. It can be inferred that combination of PSPE and simvastatin exhibits a clinically better effect as antidyslipidemic agent and antioxidant in dyslipidemic patients than simvastatin alone.

Intervention with Purple Okra Pudding and Supplement to Improve Antioxidant Status in Healthy Adults

“…Subjects were determined by screening according to the inclusion criteria and divided into three groups purposively by considering the subject's ownership of a refrigerator for pudding storage and residence. The next step was blood collection and measurements of SOD and FBG before the intervention, followed by an intervention period of 28 days according to Basu et al (2021) and Subawa et al (2022) on human subjects that showed improvement in oxidative markers after 28 days of intervention. During the intervention, nutrition education was provided in week 1, while 2×24 hour food recall and physical activity data collection was performed in weeks 1-4.…”