Therapeutic effects of EGCG: a patent review

Inflammation plays important roles at different stages of diabetes mellitus, tumorigenesis, and cardiovascular diseases. (−)-Epigallocatechin gallate (EGCG) can attenuate inflammatory responses effectively. However, the immediate early mechanism of EGCG in inflammation remains unclear. Here, we showed that EGCG attenuated the inflammatory response in the immediate early stage of EGCG treatment by shutting off Notch signaling and that the effect did not involve the 67-kDa laminin receptor, the common receptor for EGCG. EGCG eliminated mature Notch from the cell membrane and the nuclear Notch intercellular domain, the active form of Notch, within 2 min by rapid degradation via the proteasome pathway. Transcription of the Notch target gene was downregulated simultaneously. Knockdown of Notch 1/2 expression by RNA interference impaired the downregulation of the inflammatory response elicited by EGCG. Further study showed that EGCG inhibited lipopolysaccharide-induced inflammation and turned off Notch signaling in human primary macrophages. Taken together, our results show that EGCG targets Notch to regulate the inflammatory response in the immediate early stage.

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“…It has been shown to attenuate the inflammatory response (33). The mechanisms of EGCG upon inflammation have been explored in detail.…”

Section: Discussionmentioning

confidence: 99%

(−)-Epigallocatechin Gallate Targets Notch to Attenuate the Inflammatory Response in the Immediate Early Stage in Human Macrophages

et al. 2017

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“…Overall, human studies using these green tea–derived compounds have not been as successful as in vitro and animal studies . There are issues of stability and bioavailability of EGCG, which undergoes metabolism to GA in the gut, so it is unclear if the beneficial metabolic effects of EGCG are due to EGCG or GA . The effects of GA and EGCG on metabolism and PCa are controversial, with some studies showing a benefit and others reporting no effects .…”

Section: Introductionmentioning

confidence: 99%

GPCR6A Is a Molecular Target for the Natural Products Gallate and EGCG in Green Tea

Kapoor

et al. 2018

Molecular Nutrition Food Res

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“…Thus, canonical Notch signaling is important in directing macrophage function in wound repair and would be a potential target for the treatment of nonhealing diabetic wounds (4). In our previous study, (2)-epigallocatechin gallate (EGCG), which is the most abundant catechin in tea (17), was found to attenuate the inflammatory response by shutting off Notch signaling. Further study showed that EGCG could inhibit the LPS-induced inflammation and turn off Notch signaling in human primary macrophages (18).…”

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confidence: 99%

Wound healing can be improved by (—)‐epigallocatechin gallate through targeting Notch in streptozotocin‐induced diabetic mice

et al. 2018

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Delayed wound healing is one of the most prominent clinical manifestations of diabetes and lacks satisfactory treatment options. Persistent inflammation occurs in the late phase of wound healing and impairs the healing process in mice with diabetes mellitus (DM). In this study, we observed that the late wound healing in streptozotocin (STZ)-induced DM mice could be improved by (-)-epigallocatechin gallate (EGCG). The macrophage accumulation, inflammation response, and Notch signaling can be inhibited by EGCG in the skin wounds of DM mice. Furthermore, we found that the LPS-induced inflammation response including overactivated Notch signaling, was inhibited by EGCG in mouse macrophages. Moreover, we confirmed that EGCG could directly bind with mouse Notch-1. In addition, our studies indicated that diabetic wound healing was improved by EGCG treatment before or after the inflammation phase by targeting the Notch signaling pathway, which suggests that the pre-existing diabetic wound healing can be improved by EGCG. To summarize, wound healing can be improved by EGCG through targeting Notch in STZ-induced DM mice. Our findings provide insight into the therapeutic strategy for diabetic wounds and offer EGCG as a novel potential medicine to treat chronic wounds.-Huang, Y.-W., Zhu, Q.-Q., Yang, X.-Y., Xu, H.-H., Sun, B., Wang, X.-J., Sheng, J. Wound healing can be improved by (-)-epigallocatechin gallate through targeting Notch in streptozotocin-induced diabetic mice.

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Therapeutic effects of EGCG: a patent review

Cited by 176 publications

References 49 publications

(−)-Epigallocatechin Gallate Targets Notch to Attenuate the Inflammatory Response in the Immediate Early Stage in Human Macrophages

(−)-Epigallocatechin Gallate Targets Notch to Attenuate the Inflammatory Response in the Immediate Early Stage in Human Macrophages

GPCR6A Is a Molecular Target for the Natural Products Gallate and EGCG in Green Tea

Wound healing can be improved by (—)‐epigallocatechin gallate through targeting Notch in streptozotocin‐induced diabetic mice

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