Therapeutic effects of curcumin in inflammatory and immune‐mediated diseases: A nature‐made jack‐of‐all‐trades?

Abdollahi, Elham; Momtazi, Amir Abbas; Johnston, Thomas P.; Sahebkar, Amirhossein

doi:10.1002/jcp.25778

Cited by 227 publications

(125 citation statements)

References 181 publications

(280 reference statements)

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“…24 Curcumin affects many signaling pathways that lead to multiple health benefits. 28 It has been shown to be of benefit in inflammatory conditions [29][30][31][32][33] for the treatment of kidney 34 and liver [35][36][37][38] disorders, metabolic syndromes, 39 diabetes, 40 atherosclerosis, 41,42 dyslipidemia, [43][44][45][46] anxiety and/or depression, 47,48 viral diseases, 49 drug toxicity, 50 musculoskeletal, 51,52 and ischemic injury, 53 as well as having antitumor 49,[54][55][56] and antioxidant actions. 57 Furthermore, curcumin has shown efficacy in the management of degenerative eye conditions.…”

Section: Herbal Medicine Strategymentioning

confidence: 99%

Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

et al. 2019

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Cancer metastasis represents a multistep process, including alteration of cell adhesion/motility in the microenvironment and sustained angiogenesis, which is essential for supporting cancer growth in tissues that are distant from the primary tumor. There is growing evidence suggesting that heat shock proteins (HSPs) (also known as heat stress proteins), which constitute a family of stress‐inducible proteins, may be involved in the pathogenesis of cancer. Curcumin (diferuloylmethane) is a potent anti‐inflammatory, antioxidant, antimicrobial, and antitumor agent. Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer. Here, we present extent findings suggesting that curcumin may act as a potential therapeutic agent for the treatment of cancer through its regulation of HSPs.

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Section: Herbal Medicine Strategymentioning

confidence: 99%

Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

et al. 2019

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“…It is applied in Ayurvedic medicine for treatment of inflammatory diseases for a long time. This plant and its bioactive polyphenols, curcuminoids, have been shown to exert several therapeutic actions including anti-asthmatic, 34 antioxidant, [181][182][183] immunomodulatory, 35 hepatoprotective, 36,37 antitumor, 38,40,41 and anti-inflammatory 39,184,185 activities.…”

Section: Curcuma Longamentioning

confidence: 99%

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

et al. 2019

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Traumatic brain injury (TBI) is the most prevalent health problem affecting all age groups, and leads to many secondary problems in other organs especially kidneys, gastrointestinal tract, and heart function. In this review, the search terms were TBI, fluid percussion injury, cold injury, weight drop impact acceleration injury, lateral fluid percussion, cortical impact injury, and blast injury. Studies with Actaea racemosa, Artemisia annua, Aframomum melegueta, Carthamus tinctorius, Cinnamomum zeylanicum, Crocus sativus, Cnidium monnieri, Curcuma longa, Gastrodia elata, Malva sylvestris, Da Chuanxiong Formula, Erigeron breviscapus, Panax ginseng, Salvia tomentosa, Satureja khuzistanica, Nigella sativa, Drynaria fortune, Dracaena cochinchinensis, Polygonum cuspidatum, Rosmarinus officinalis, Rheum tanguticum, Centella asiatica, and Curcuma zedoaria show a significant decrease in neuronal injury by different mechanisms such as increasing superoxide dismutase and catalase activities, suppressing nuclear factor kappa B (NF‐κB), interleukin 1 (IL‐1), glial fibrillary acidic protein, and IL‐6 expression. The aim of this study was to evaluate the neuroprotective effects of medicinal plants in central nervous system pathologies by reviewing the available literature.

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“…Curcumin, a highly bioactive herbal component, exhibits antiinflammatory activity through multiple mechanisms including inhibition of the NF-κB pathway. 18 In order to test the therapeutic benefits of curcumin in patients with interstitial cystitis/bladder pain syndrome, we examined the effects of curcumin on CPA-induced cystitis/bladder pain in mice. We found that the oral preadministration of curcumin at 100 mg/kg prevented CPA-induced increases in the…”

Section: Effects Of Curcumin An Inhibitor Of Nf-κbrelated Signalsmentioning

confidence: 99%

Involvement of NF‐κB in the upregulation of cystathionine‐γ‐lyase, a hydrogen sulfide‐forming enzyme, and bladder pain accompanying cystitis in mice

Ozaki

Tsubota

Sekiguchi

et al. 2017

Clin Exp Pharma Physio

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Hydrogen sulfide (H S) is generated from l-cysteine by multiple enzymes including cystathionine-γ-lyase (CSE), and promotes nociception by targeting multiple molecules such as Ca 3.2 T-type Ca channels. Bladder pain accompanying cyclophosphamide (CPA)-induced cystitis in mice has been shown to involve the functional upregulation of the CSE/H S/Ca 3.2 pathway. Therefore, we investigated whether NF-κB, as an upstream signal of the CSE/H S system, contributes to bladder pain in mice with CPA-induced cystitis. Bladder pain-like nociceptive behaviour was observed in CPA-treated mice, and referred hyperalgesia was evaluated by the von Frey test. Isolated bladder weights were assessed to estimate bladder swelling, and protein levels were measured by Western blotting. CPA, administered intraperitoneally, induced nociceptive behaviour, referred hyperalgesia and increased bladder weights in mice. β-Cyano-l-alanine, a reversible selective CSE inhibitor, prevented CPA-induced nociceptive behaviour, referred hyperalgesia, and, in part, increases in bladder weight. CPA markedly increased phosphorylated NF-κB p65 levels in the bladder, an effect that was prevented by pyrrolidine dithiocarbamate (PDTC), an NF-κB inhibitor. PDTC and curcumin, which inhibits NF-κB signals, abolished CPA-induced nociceptive behaviour, referred hyperalgesia and, in part, increases in bladder weight. CPA caused the overexpression of CSE in the bladder, and this was prevented by PDTC or curcumin. The CPA-induced activation of NF-κB signals appeared to cause CSE overexpression in the bladder, contributing to bladder pain and in part swelling, possibly through H S/Ca 3.2 signaling. Therefore, NF-κB-inhibiting compounds including curcumin may be useful for the treatment of cystitis-related bladder pain.

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Therapeutic effects of curcumin in inflammatory and immune‐mediated diseases: A nature‐made jack‐of‐all‐trades?

Cited by 227 publications

References 181 publications

Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Involvement of NF‐κB in the upregulation of cystathionine‐γ‐lyase, a hydrogen sulfide‐forming enzyme, and bladder pain accompanying cystitis in mice

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