Therapeutic Effects of Carbogen Inhalation and Lipo-Prostaglandin E1 in Sudden Hearing Loss

Lee, Hyun Jin; Park, Chong Yoon; Lee, Jae Heon; Yang, Hoon Shik; Kim, Joo Hyun; Ban, Myung Jin; Moon, In Seok

doi:10.3349/ymj.2012.53.5.999

Cited by 10 publications

(7 citation statements)

References 21 publications

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“…[23] The 'favorable' recovery (Sigel's type 1 and 2) rate of the carbogen group was significantly higher than that of the lipo-PGE1 group and the control group. [24] Whereas in the present study, there was a significant difference in the medical treatment plus carbogen group compared to the other groups in terms of treatment outcome. The difference found between our two studies might be due to the increased number of patients in the latter.…”

Section: Discussioncontrasting

confidence: 67%

The importance of the first three days and other diagnostic indicators in sudden hearing loss

Tüzemen

Kasapoğlu²,

Hizalan³

et al. 2016

Kulak Burun Bogaz Ihtis Derg

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Objectives: This study aims to compare different therapy methods used for sudden sensorineural hearing losses, to determine the prognostic factors and particularly to investigate the importance of starting the therapy within the first three days of the prognosis. Patients and Methods:Between January 1995 and December 2008, the files of 213 patients who were treated in our clinic were reviewed. A total of 155 patients who met the inclusion criteria were included in the study. The study groups were classified according to the prognostic and audiometric factors. Results:With regard to the effectiveness of treatment options, post-treatment audiometric improvement was significantly better in the patients treated with carbogen in addition to the medical therapy compared to the other groups (p=0.018). In terms of the patient characteristics at the time of admission, having vertigo, presence of a descending type audiogram curve and severe hearing loss affected the success of treatment negatively, while mild hearing loss and presence of an ascending type audiogram curve had a positive effect. The recovery rate was higher in patients who were admitted within the first three days (p=0.005). Conclusion:It was found that starting the therapy within the first three days and adding the carbogen to the conventional medical treatment may improve the outcome of the treatment.Keywords: Carbogen; first three days; prognosis; sudden hearing loss. ÖZAmaç: Bu çalışmada ani sensörinöral işitme kayıpları için kullanılan farklı tedavi yöntemleri karşılaştırıldı, prognostik faktörler belirlendi ve özellikle prognozun ilk üç gününde tedaviye başlamanın önemi araştırıldı. Bulgular:Tedavi seçeneklerinin etkililiği ile ilgili olarak, tıbbi terapiye ek olarak karbojen ile tedavi edilen hastalarda tedavi sonrası odyometrik iyileşme diğer gruplarla karşılaştırıldığında anlamlı olarak daha iyiydi (p=0.018). Başvuru sırasında hasta özellikleri açısından baş dönmesi, odyogramda alçalan eğri ve ciddi işitme kaybı tedavinin başarısını olumsuz etkilerken, hafif işitme kaybı ve odyogramda yük-selen eğrinin varlığı tedavi için olumlu bir etkiye sahiptir. İlk üç gün içinde başvuran hastalarda iyileşme oranı daha yüksekti (p=0.005). Sonuç:Tedaviye ilk üç gün içinde başlamanın ve konvansiyonel tıbbi tedaviye karbojenin eklenmesinin tedavinin sonucunu iyileştire-bileceği gözlendi.Anahtar Sözcükler: Karbojen; ilk üç gün; prognoz; ani işitme kaybı.

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Section: Discussioncontrasting

confidence: 67%

The importance of the first three days and other diagnostic indicators in sudden hearing loss

Tüzemen

Kasapoğlu²,

Hizalan³

et al. 2016

Kulak Burun Bogaz Ihtis Derg

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“…Lee HJ et al 15 in 2012 retrospectively reviewed 202 patients with idiopathic SHL. In their study, it was concluded that Carbogen inhalation added to steroid was a more effective treatment than Lipo-PGE1 added to steroid or steroid alone in patients with SHL.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Carbogen Therapy in Sudden Sensorineural Hearing Loss

Priyamvada¹,

Yande²

2018

jemds

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BACKGROUND Sudden Hearing Loss (SHL) is a rare disease accounting for 1% of all sensorineural hearing loss cases, but it is considered an otological emergency. The sooner the treatment begins, the outcome proves to be better. Different theories have been postulated with regard to determining its cause. Most accepted treatment at the present time is systemic steroid therapy. The purpose of our study was to compare the efficacy of carbogen therapy combined with steroids, is whether or not superior to steroids alone in the treatment of sudden hearing loss. MATERIALS AND METHODS This prospective, non-randomised, controlled parallel trial included 60 patients with idiopathic SHL who visited our clinic within 14 days of symptom onset between August 2013 and February 2015. All patients received oral prednisolone for 10 days. Of the 60 patients, 30 received no additional treatment and 30 received additional carbogen inhalation. Hearing improvement was measured using Siegel's criteria. RESULTS We observed in our study that complete recovery at two months occurred in 33.33% and 26.67% subjects in Group 1 [Carbogen therapy plus steroids] and Group 2 [steroids alone] correspondingly. As for partial recovery, 53.33% and 66.67% in Group 1 and 2 correspondingly (Siegel's criteria 1 and 2). Slight improvement was noticed as follows at 10 th sitting 23.33% and 13.33% and at 2 months 13.33% and 6.67% in corresponding group. Though these results show that carbogen therapy is better than steroids, the data is calculated to be statistically insignificant using Fisher's exact test (p-value 0.267 and 0.591 > 0.05). We also found that there is statistically significant [p-value 0.01] association between age of onset of sensorineural hearing loss and betterment of hearing. Younger the age at the time of onset of hearing loss, there are better chances of hearing gain towards normal hearing sensitivity. CONCLUSION Carbogen inhalation added to steroids was a more effective treatment than steroids alone in patients with idiopathic sudden sensorineural hearing loss.

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“…소아 돌발성 난청의 치료는 성인 돌발성 난청과 마찬가지로 스테로이드 치료와 함께 저분자 덱스트란 제제 및 혈관확장제 (prostaglandin E1), 11) 혈류순환 개선제, Carbogen 흡입법을 시행하였다. 12,13) 성인 돌발성 난청 환자의 경우 고용량의 전신 스테로이드 (methylprednisolone)를 1~4일째 80 mg/day, 5~6일째 60 mg/day, 7~8일째 40 mg/day, 9~10일째 20 mg/day, 11~12 일째 10 mg/day로 줄여가며 근육 주사하였고, 소아의 경우 1 mg/kg/day의 일정 용량으로 총 12일간 입원 중 정맥 주사하 였다. 14) 소아 환자 중 만 10세 이상의 9예에서 국소 마취 하에 고실 내 스테로이드 주입술을 시행하였다.…”

Section: 방 법unclassified

Clinical Characteristics and Hearing Results of Sudden Sensorineural Hearing Loss in Child

Shin

Jung

Sung

et al. 2016

Korean J Otorhinolaryngol-Head Neck Surg

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Background and ObjectivesZZSudden sensorineural hearing loss (SSNHL) in children can occur just as can in adults; in fact, it may last throughout the entire life of a child, affecting the individual much more than when it does to an adult. As there are only a few studies that have focused on SSNHL in childhood, we investigated the clinical characteristics and hearing outcomes of pediatric SSNHL. Subjects and MethodZZA retrospective review of patients from November 2005 to May 2014 was carried out. Thirty nine patients under the age 15, who were hospitalized due to SSNHL were enrolled. Of these patients, 226 patients over the age of 15 were collected as a comparison group. Age, sex, underlying disease, site of hearing loss and duration from the onset to treatment were analyzed. We evaluated the overall recovery rate as well as the recovery rate according to accompanying diseases. ResultsZZRecovery rates were comparable between the pediatric and the adult group. Overall recovery rate was 60% in the pediatric group. Unlike for the adult group, dizziness and tinnitus were not a prognostic factor in the pediatric group. Pediatric patients showed similar overall recovery, whether the treatment initiation was under 7 days or more. Recurrence was seen in 3 patients, of which 2 showed complete recovery. ConclusionZZThe recovery rate for SSNHL was similar for the pediatric and the adult groups. A higher recurrence rate may alert clinicians to be aware of hearing changes after the recovery in pediatric patients.

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Therapeutic Effects of Carbogen Inhalation and Lipo-Prostaglandin E1 in Sudden Hearing Loss

Cited by 10 publications

References 21 publications

The importance of the first three days and other diagnostic indicators in sudden hearing loss

The importance of the first three days and other diagnostic indicators in sudden hearing loss

Therapeutic Effects of Carbogen Therapy in Sudden Sensorineural Hearing Loss

Clinical Characteristics and Hearing Results of Sudden Sensorineural Hearing Loss in Child

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