Therapeutic Effects of Annona senegalensis Pers Stem Bark Extracts in Experimental African Trypanosomiasis

Abstract

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In-silico Investigation of Antitrypanosomal Phytochemicals from Nigerian Medicinal Plants

“…5,7-Digalloylcatechin was the strongest binding ligand for TbPTR1 (−42.7 kcal/mol) and 4 ′ ,7-digalloylcatechin was the strongest binding ligand for TbODC (−41.4 kcal/mol). A number of these polyphenolic ligands showed strong docking interactions with TbAK, TbPTR1, TbCYP51, TbNH, and TbUDPGE, and interactions with these protein targets may be responsible for the antitrypanosomal activity of A. nilotica [46]. The docking study suggests that rhodesain, TbDHFR, TbTR, TbCatB, and TbHSP90 are not targets for A. nilotica phytochemicals.…”

“…Right: Lowest-energy docked pose of lawsone in the active site of T. brucei cathepsin B (TbCatB, PDB 3hhi [46]; S⋅⋅⋅C(2) = 3.73 Å).…”

“…Right: With TbCatB (PDB 3hhi [46]). Note the proximity and orientation of the quinone moiety with the cysteine sulfur atoms in the active sites.…”

Subchronic Toxicity Studies of Methanol Extract of Eucalyptus Camaldulensis (Leaf) In Wister Rats

“…These were done according to the method described by [8]. The leaves of E. Camaldulensis were removed fresh, washed with running tap water and dried at room temperature.…”

Antibacterial Activity of Bioflavonoid from Fruit Pulps of Acacia nilotica Willd

“…It also contains L-arabinose, catechol, galactan, galactoaraban, galactose, Nacetyl djenkolic acid, sulphoxides and pentosan. The seeds contain crude protein (18.6%), ether extract (4.4%), fiber (10.1%), nitrogen-free extract (61.2%), ash (5.7%) and silica (0.44%); phosphorus (0.29%) and calcium (0.90%) of dry matter (17%) [3]. Phytochemical analysis of stem bark of A. nilotica showed the presence of carbohydrates, saponins, tannins, and cardiac glycosides [4].…”