Therapeutic effects of acupuncture on blood glucose level among patients with type-2 diabetes mellitus: A randomized clinical trial

Kazemi, Amir Hooman; Wang, Wei; Wang, Yanping; Khodaie, Faezeh; Rezaeizadeh, Hossein

doi:10.1016/j.jtcms.2019.02.003

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…These effects may be explained neuroanatomically by variations in the segmental innervation of tissues at these locations [ 59 , 60 ]. The acupuncture treatment reduced the HbA1c level significantly in comparison with that in the sham-acupuncture group [ 61 ]. The effectiveness of acupuncture in treating diseases related to IR had been reported, and acupuncture had an advantage over control groups in decreasing fasting blood glucose (FBG) and fasting insulin levels [ 62 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic Effect of Electroacupuncture at ST25 Through Neural Regulation of the Pancreatic Intrinsic Nervous System

Liu

et al. 2021

Mol Neurobiol

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Electroacupuncture (EA) is considered to have potential antidiabetic effects; however, the role of the pancreatic intrinsic nervous system (PINS) in EA-induced amelioration of type 2 diabetes (T2DM) remains unclear. Therefore, we investigated whether EA at ST25 exerts any beneficial effects on insulin resistance (IR), inflammation severity, and pancreatic β cell function via the PINS in a rat model of a high-fat diet-streptozotocin (HFD/STZ)-induced diabetes. To this end, Sprague Dawley rats were fed with HFD to induce IR, followed by STZ (35 mg/kg, i.p.) injection to establish the T2DM model. After hyperglycemia was confirmed as fasting glucose level > 16.7 mmol/L, the rats were treated with EA (2 mA, 2/15 Hz) for the next 28 days. Model rats showed increased serum glucose, insulin, IR, and TNF-α levels with a concomitant decrease in β cell function. Microscopy examination of the pancreas revealed pathological changes in islets, which reverted to near-normal levels after EA at ST25. EA improved islet cell morphology by increasing islet area and reducing vacuolation. EA at ST25 decreased transient receptor potential vanilloid 1 (TRPV1) and increased substance P (SP) and calcitonin gene-related peptide (CGRP) expression. Subsequently, insulin secretion decreased and impaired pancreatic endocrine function was restored through the TRPV1 channel (SP/CGRP)-insulin circuit. EA increased choline acetyltransferase and neuropeptide Y expression and controlled inflammation. It also enhanced the cocaine and amphetamine-regulated transcript prepropeptide expression and promoted glucagon-like peptide-1 secretion. Additionally, the electrophysiological activity of PINS during acupuncture (2.71 ± 1.72 Hz) was significantly increased compared to the pre-acupuncture frequency (0.32 ± 0.37 Hz, P < 0.05). Thus, our study demonstrated the beneficial effect of EA on β cell dysfunction via the PINS in rat models of HFD-STZ-induced T2DM.

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Section: Discussionmentioning

confidence: 99%

Hypoglycemic Effect of Electroacupuncture at ST25 Through Neural Regulation of the Pancreatic Intrinsic Nervous System

Liu

et al. 2021

Mol Neurobiol

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“…35 Although criticized as lacking scientific evidence, acupuncture has shown effectiveness in lowering glucose levels when used in conjunction with metformin or other T2D therapies. [36][37][38] A 12-week randomized control trial where the intervention group (n = 40) received acupuncture treatment combined with metformin and control group (n = 40) received sham acupuncture combined with metformin found the treatment group had significantly lower fasting plasma glucose (P = 0.034) and HbA1c levels (P = 0.007) compared with placebo. 36 Also, a review of human and animal studies investigating acupuncture's effect on insulin resistance reported acupuncture when used alone or in conjunction with herbal medicines, metformin, or lifestyle changes can lower insulin resistance.…”

Section: 'Cosmopolitan' Medicine and Traditional Medicine Approachesmentioning

confidence: 99%

A review of the role of cultural practices, values, and norms in type II diabetes treatment for Chinese immigrants

Ormiston¹

2023

J of Asian Health

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Although Type II diabetes (T2D) prevalence in US Chinese immigrants continues to rise, gaps in research and clinical care persist. These gaps are largely due to generalizations of the Asian immigrant population, barriers within biomedical culture, and a lack of culturally sensitive treatment plans. Little attention is paid to the unique sociocultural factors and contexts within each subpopulation, such as family influences or traditional medicine approaches. After an analysis of available literature, folk interpretations of disease, the family unit, and cultural food practices were found to be significant influences on T2D treatment. As they navigate their treatment, Chinese immigrants grapple with issues such as the stigmatization of insulin, the importance of providing food as care, and family well-being and harmony. Understanding how and why these elements of PVN affect T2D treatment is crucial to tailoring medical care to the needs of Chinese immigrant communities.

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“…In recent years, acupuncture has been widely used in the treatment of diabetes and its complications [23]. Acupuncture or moxibustion may effectively treat irritable bowel syndrome (IBS) by adjusting the ratio of bene cial and pathogenic bacteria and inhibiting the expression of in ammatory factors [24].…”

Section: Introductionmentioning

confidence: 99%

Uncovering the biological mechanism of acupuncture alleviating diabetic nephropathy through homeostasis regulation the of intestinal flora and T lymphocytes

Lu,

Li,

et al. 2023

Preprint

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Diabetic nephropathy (DN) is a major healthcare challenge in the management of diabetic patients.The aim of this study was to investigate the protective role of acupuncture treatment in the treatment of DN.After DN modelling, DN rats were treated with acupuncture (4 weeks) and diabetic metabolic parameters and urinary proteins were measured. Hematoxylin-Eosin (HE) staining and Periodic Acid-Schiff(PAS) staining were conducted to assess the degree of renal structural damage. Enzyme-linked immunosorbent assay (ELISA) was used to detect inflammatory factors mediated by renal T-lymphocyte polarization.Western Blotting (WB) was used to analyze the FOXP3/NF-κB signaling pathway. Composition of T-lymphocyte taxa was detected by flow cytometric analysis. Furtherment, the composition of intestinal microorganisms was detected by 16S rDNA sequencing to explore the effects of acupuncture treatment on the composition and structure of intestinal flora in DN rats.Herein, our results show that acupuncture treatment alleviates renal pathological changes, reduces expression of pro-inflammatory factors, and remodels T-lymphocyte homeostasis in DN rats. Detection of intestinal microorganisms showed that acupuncture improved the composition and structure of intestinal flora and up-regulated the content of probiotics. Our study reveals that remodeling of T-lymphocyte homeostasis through the microbial-gut-kidney axis and consequent inhibition of pro-inflammatory cytokine activation may be the underlying biological mechanism of acupuncture in the treatment of DN.

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Therapeutic effects of acupuncture on blood glucose level among patients with type-2 diabetes mellitus: A randomized clinical trial

Cited by 5 publications

References 22 publications

Hypoglycemic Effect of Electroacupuncture at ST25 Through Neural Regulation of the Pancreatic Intrinsic Nervous System

Hypoglycemic Effect of Electroacupuncture at ST25 Through Neural Regulation of the Pancreatic Intrinsic Nervous System

A review of the role of cultural practices, values, and norms in type II diabetes treatment for Chinese immigrants

Uncovering the biological mechanism of acupuncture alleviating diabetic nephropathy through homeostasis regulation the of intestinal flora and T lymphocytes

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