Therapeutic Effects of (5R)-5-Hydroxytriptolide on Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via lncRNA WAKMAR2/miR-4478/E2F1/p53 Axis

Zhou, Xinpeng; Xie, Dizhi; Huang, Jie; Lü, Aiping; Wang, Rongsheng; Jin, Yehua; Zhang, Runrun; Chang, Cen; Xu, Lingxia; Xu, Linshuai; Fan, Jun‐Yu; Liang, Chao; He, Dongyi

doi:10.3389/fimmu.2021.605616

Cited by 20 publications

(23 citation statements)

References 54 publications

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“…For example, drugs used in clinical therapy of RA, such as (5R)-5-hydroxy triptolide (LLDT-8), etc., have been found to have a good therapeutic effect by inhibiting the migration and invasion of FLSs ( 69 ). Zhou et al.…”

Section: The Relationship Between Lncrnas and The Pathological Features Of Ramentioning

confidence: 99%

“…LLDT-8 upregulates the expression of lncRNA WAKMAR2, which is negatively correlated with the proliferation and invasion of FLSs and the production of proinflammatory cytokines. Knockout of WAKMAR2 can weaken the therapeutic effect of LLDT-8 on RA ( 69 ). These studies have shown that drugs that target LncRNAs can have broad prospects in the clinical diagnosis and treatment of RA.…”

Section: The Prospect Of Lncrnas In the Diagnosis And Treatment Of Ramentioning

confidence: 99%

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LncRNAs and Rheumatoid Arthritis: From Identifying Mechanisms to Clinical Investigation

Huang

et al. 2022

Front. Immunol.

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Rheumatoid arthritis (RA) is a systemic chronic autoinflammatory disease, and the synovial hyperplasia, pannus formation, articular cartilage damage and bone matrix destruction caused by immune system abnormalities are the main features of RA. The use of Disease Modifying Anti-Rheumatic Drugs (DMARDs) has achieved great advances in the therapy of RA. Yet there are still patients facing the problem of poor response to drug therapy or drug intolerance. Current therapy methods can only moderate RA progress, but cannot stop or reverse the damage it has caused. Recent studies have reported that there are a variety of long non-coding RNAs (LncRNAs) that have been implicated in mediating many aspects of RA. Understanding the mechanism of LncRNAs in RA is therefore critical for the development of new therapy strategies and prevention strategies. In this review, we systematically elucidate the biological roles and mechanisms of action of LncRNAs and their mechanisms of action in RA. Additionally, we also highlight the potential value of LncRNAs in the clinical diagnosis and therapy of RA.

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Section: The Relationship Between Lncrnas and The Pathological Features Of Ramentioning

confidence: 99%

Section: The Prospect Of Lncrnas In the Diagnosis And Treatment Of Ramentioning

confidence: 99%

LncRNAs and Rheumatoid Arthritis: From Identifying Mechanisms to Clinical Investigation

Huang

et al. 2022

Front. Immunol.

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“…During the pathogenesis of RA, FLS show high proliferation, high invasiveness, and tumor-like changes, which play an important role in the development of RA (3,4). Previous studies have shown that apoptosis and autophagy in FLS are closely related to the development of RA (5,6). Unlike apoptosis, pyroptosis is a newly discovered form of programmed cell death that releases powerful immune cytokines such as IL-1b and IL-18 (7).…”

Section: Introductionmentioning

confidence: 99%

SFRP1 Negatively Modulates Pyroptosis of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis: A Review

et al. 2022

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Secreted frizzled-related protein 1 (SFRP1) is a member of secretory glycoprotein SFRP family. As a primitive gene regulating cell growth, development and transformation, SFRP1 is widely expressed in human cells, including various cancer cells and fibroblast-like synoviocytes (FLS) of rheumatoid arthritis (RA). Deletion or silencing of SFRP1 involves epigenetic and other mechanisms, and participates in biological behaviors such as cell proliferation, migration and cell pyroptosis, which leads to disease progression and poor prognosis. In this review, we discuss the role of SFRP1 in the pathogenesis of RA-FLS and summarize different experimental platforms and recent research results. These are helpful for understanding the biological characteristics of SFRP1 in RA, especially the mechanism by which SFRP1 regulates RA-FLS pyroptosis through Wnt/β-catenin and Notch signaling pathways. In addition, the epigenetic regulation of SFRP1 in RA-FLS is emphasized, which may be considered as a promising biomarker and therapeutic target of RA.

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“…In addition, lncRNAs are responsible for the integrity of nuclear structure and can regulate the expression of nearby genes or genes in other parts of the cell by interacting with proteins, RNAs and DNAs ( 7 ). LncRNAs are a potential biomarker ( 9 ) and act as crucial regulators of Mφs polarization in response to intracellular or extracellular stimulation. various lncRNAs exhibit different functions in Mφs infiltration and polarization and regulate the secretion of inflammatory cytokines released by Mφs ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Regulatory Mechanism of lncRNAs in M1/M2 Macrophages Polarization in the Diseases of Different Etiology

Jiang

2022

Front. Immunol.

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Precise expression and regulation of genes in the immune system is important for organisms to produce strong immunity towards pathogens and limit autoimmunity. In recent years, an increasing number of studies has shown that long noncoding RNAs (lncRNAs) are closely related to immune function and can participate in regulating immune responses by regulating immune cell differentiation, development, and function. As immune cells, the polarization response of macrophages (Mφs) plays an important role in immune function and inflammation. LncRNAs can regulate the phenotypic polarization of Mφs to M1 or M2 through various mechanisms; promote pro-inflammatory or anti-inflammatory effects; and participate in the pathogenesis of cancers, inflammatory diseases, infections, metabolic diseases, and autoimmune diseases. In addition, it is important to explore the regulatory mechanisms of lncRNAs on the dynamic transition between different Mφs phenotypes. Thus, the regulatory role of lncRNAs in the polarization of Mφs and their mechanism are discussed in this review.

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Therapeutic Effects of (5R)-5-Hydroxytriptolide on Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via lncRNA WAKMAR2/miR-4478/E2F1/p53 Axis

Cited by 20 publications

References 54 publications

LncRNAs and Rheumatoid Arthritis: From Identifying Mechanisms to Clinical Investigation

LncRNAs and Rheumatoid Arthritis: From Identifying Mechanisms to Clinical Investigation

SFRP1 Negatively Modulates Pyroptosis of Fibroblast‐Like Synoviocytes in Rheumatoid Arthritis: A Review

Regulatory Mechanism of lncRNAs in M1/M2 Macrophages Polarization in the Diseases of Different Etiology

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