Therapeutic effect of vascular interventional therapy and aspirin combined with defibrase on cerebral ischemia in rats

Abstract

Therapeutic effect of vascular interventional therapy and aspirin combined with defibrase in the treatment of cerebral ischemia in rat model were investigated. Ninety rats were selected to establish cerebral ischemia model. Animal models were randomly divided into observation group and control group, with 45 rats in each group. Rats in observation group were treated with vascular intervention, and control group was treated with aspirin combined with defibrase. Peak systolic velocity (Vs) and end-diastolic velocity (Vd) were compared between two groups before and after 12 months of treatment. Therapeutic effects were compared before and after 6 months, and before and after 12 months of treatment. Vs and Vd of vascular lesions in observation group at 12 months were reduced after treatment, and were significantly lower than those in control group (p<0.05). After treatment, Vs and Vd in observation group were significantly reduced (p<0.05). There was no significant difference in Vs and Vd values between the groups before treatment (p>0.05). NDS scores in observation group were significantly lower than those in control group at 6 months and 1 year after treatment (p<0.05). There were no significant changes in NDS score at 6 and 12 months after treatment in control group compared with pretreatment group (p>0.05). NDS in observation group was significantly reduced at 6 and 12 months after treatment compared with pretreatment level (p<0.05). One year after treatment, incidence of cerebral infarction and transient ischemic attack and mortality in observation group were significantly lower than those in the control group (p<0.05). Intracranial vascular interventional therapy can achieve satisfactory outcomes in the treatment of cerebral ischemia, and can effectively promote nerve function recovery, and reduce the incidence of cerebrovascular diseases and mortality.

Ambiguous Effects of Autophagy Activation Following Hypoperfusion/Ischemia

“…A more severe reduction of CBF, such as that occurring in cerebral ischemia, may be produced by increasing the number of vessels occlusion. For instance, the models of three or four vessel occlusions, such as the permanent bilateral occlusion of the vertebral arteries, followed by the transient bilateral occlusion of the carotid arteries [ 116 ], or the permanent occlusion of the middle cerebral artery, allows one to study the ischemic injury produced by a sudden and consistent reduction of CBF [ 117 , 118 , 119 ]. On the other hand, the vascular anatomy among mammals shows variations between species and even strains, with significant species-specific differences in the number of arterial collaterals, upon which the capacity to restore the blood flow after vessel occlusion depends [ 120 ].…”