Therapeutic Effect of Sepia pharaonis Ink Extract and Ellagic Acid on the Toxicity Induced by Cyclophosphamide in Male Albino Rats

Abstract

Cyclophosphamide (CP), an alkylating agent, is chemotherapy for cancer that suppress the immune system (Ahlmann and Hempel, 2016). This drug was used for the treatment of chronic and acute leukemia, multiple myeloma, lymphoma, and rheumatic arthritis (Nelius et al., 2010). Hepatic cytochrome P450 (CYP) isoenzyme activity can be affected by CP in animals through the induction of gene expression of this enzyme (Xie et al., 2002). Low counts of white blood cells, appetite loss, hair loss, vomiting, and bladder bleeding are the common side effects of CP. Furthermore, allergic reactions, pulmonary fibrosis and infertility are severe side effects of the drug (Wang et al., 2009).